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HSPG2 recombinant protein :: Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS953064 HSPG2 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $980 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $980 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,200 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,200 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,425 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,425 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,885 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,885 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,920 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,810 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2), Recombinant Protein

 Also Known As   

Recombinant Human Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2), partial

 Product Gene Name   

HSPG2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    4197-4391. Partial, provide the full length of LG3 peptide chain.
 Sequence    DAPGQYGAYF HDDGFLAFPG HVFSRSLPEV PETIELEVRT STASGLLLWQ GVEVGEAGQG KDFISLGLQD GHLVFRYQLG SGEARLVSED PINDGEWHRV TALREGRRGS IQVDGEELVS GRSPGPNVAV NAKGSVYIGG APDVATLTGG RFSSGITGCV KNLVLHSARP GAPPPQPLDL QHRAQAGANT RPCPS
 OMIM    142461
 3D Structure    ModBase 3D Structure for P98160
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HSPG2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HSPG2. It may not necessarily be applicable to this product.
 NCBI GI #    629266065
 NCBI GeneID    3339
 NCBI Accession #    NP_001278789.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001291860.1 [Other Products]
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 UniProt Primary Accession #    P98160 [Other Products]
 UniProt Secondary Accession #    Q16287; Q5SZI3; Q9H3V5 [Other Products]
 UniProt Related Accession #    P98160 [Other Products]
 Molecular Weight    468,830 Da
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 NCBI Official Full Name    basement membrane-specific heparan sulfate proteoglycan core protein isoform a
 NCBI Official Synonym Full Names    heparan sulfate proteoglycan 2
 NCBI Official Symbol    HSPG2 [Similar Products]
 NCBI Official Synonym Symbols   
PLC; SJA; SJS; HSPG; SJS1; PRCAN
[Similar Products]
 NCBI Protein Information    basement membrane-specific heparan sulfate proteoglycan core protein
 UniProt Protein Name    Basement membrane-specific heparan sulfate proteoglycan core protein
 UniProt Synonym Protein Names   
Perlecan; PLC
 Protein Family    Basement membrane-specific heparan sulfate proteoglycan core protein
 UniProt Gene Name    HSPG2 [Similar Products]
 UniProt Synonym Gene Names    HSPG; PLC [Similar Products]
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 NCBI Summary for HSPG2    This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
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 UniProt Comments for HSPG2    Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.
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 Research Articles on HSPG2    1. Mutations in this gene are responsible for the allelic Skeletal Dysplasias Schwartz-Jampel syndrome type 1 and the Silverman-Handmaker type of Dyssegmental Dysplasia, both of which are autosomal recessive.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSPG2 recombinant proteinPathways associated with HSPG2 recombinant protein
 Reference Product  PubMed Publications
 SDC2 recombinant protein  >2 publications with HSPG2 and SDC2
 HPSE recombinant protein  >1 publications with HSPG2 and HPSE
 BGN recombinant protein  >1 publications with HSPG2 and BGN
 APP recombinant protein  >1 publications with HSPG2 and APP
 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 Amyloid Fiber Formation Pathway antibodies  Amyloid Fiber Formation Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Defective B3GALT6 Causes EDSP2 And SEMDJL1 Pathway antibodies  Defective B3GALT6 Causes EDSP2 And SEMDJL1 Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
 Defective EXT2 Causes Exostoses 2 Pathway antibodies  Defective EXT2 Causes Exostoses 2 Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
Diseases associated with HSPG2 recombinant proteinOrgans/Tissues associated with HSPG2 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >21 publications with HSPG2 and Nervous System Diseases
 Osteochondrodysplasias Antibodies  >10 publications with HSPG2 and Osteochondrodysplasias
 Disease Models, Animal Antibodies  >9 publications with HSPG2 and Disease Models, Animal
 Kidney Diseases Antibodies  >7 publications with HSPG2 and Kidney Diseases
 Neurodegenerative Diseases Antibodies  >6 publications with HSPG2 and Neurodegenerative Diseases
 Movement Disorders Antibodies  >6 publications with HSPG2 and Movement Disorders
 Dyssegmental dysplasia Antibodies  >6 publications with HSPG2 and Dyssegmental dysplasia
 Alzheimer Disease Antibodies  >5 publications with HSPG2 and Alzheimer Disease
 Hypertrophy Antibodies  >3 publications with HSPG2 and Hypertrophy
 Inflammation Antibodies  >3 publications with HSPG2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >19 publications with HSPG2 and Bone
 Blood Antibodies  >16 publications with HSPG2 and Blood
 Muscle Antibodies  >15 publications with HSPG2 and Muscle
 Vascular Antibodies  >14 publications with HSPG2 and Vascular
 Connective Tissue Antibodies  >10 publications with HSPG2 and Connective Tissue
 Brain Antibodies  >6 publications with HSPG2 and Brain
 Kidney Antibodies  >6 publications with HSPG2 and Kidney
 Embryonic Tissue Antibodies  >6 publications with HSPG2 and Embryonic Tissue
 Mouth Antibodies  >5 publications with HSPG2 and Mouth
 Ovary Antibodies  >5 publications with HSPG2 and Ovary
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