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Bcl2 recombinant protein :: Bcl 2, aa1-211 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS636791 Bcl2 recombinant protein
Unit / Price
0.1 mg  /  $695 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bcl 2, aa1-211 (Bcl2), Recombinant Protein

 Also Known As   

Bcl 2, aa1-211, Recombinant, Human (B-cell lymphoma protein 2 alpha, Apoptosis regulator Bcl-2, Bcl-2)

 Product Gene Name   

Bcl2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 13; NC_005112.3 (31758213..31919850, complement). Location: 13p13
 3D Structure    ModBase 3D Structure for P49950
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 Purity/Purification    Highly Purified
0.9
 Form/Format    Supplied as a liquid in 25mM TrisHCl, pH 8.0, 100mM NaCl, 0.05% Tween-20, 30% glycerol, 3 mM DTT.
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 Preparation and Storage    Aliquot to avoid repeated freezing and thawing and store at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.
 Other Notes    Small volumes of Bcl2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Bcl2 recombinant protein

   Bcl-2, also known as B-cell lymphoma protein 2 alpha, is an anti-apoptotic protein located primarily in the outer mitochondrial membrane that blocks the apoptotic death of some cells such as lymphocytes. BCL-2 is thought to regulate cell death by controlling the mitochondrial membrane permeability during apotosis. Bcl-2 exerts its anti-apoptotic function through inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). The Bcl-2 gene has been related with a number of cancers, including melanoma, breast, prostate, and lung carcinomas, as well as schizophrenia and autoimmunity.
 Product Categories/Family for Bcl2 recombinant protein    Molecular Biology; MB-Apoptosis
 Application Notes for Bcl2 recombinant protein    Suitable for use in the study of apoptosis, screening inhibitors, and selectivity profiling.
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NCBI/Uniprot data below describe general gene information for Bcl2. It may not necessarily be applicable to this product.
 NCBI GI #    1004379
 NCBI GeneID    24224
 NCBI Accession #    AAA77687.1 [Other Products]
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 UniProt Primary Accession #    P49950 [Other Products]
 UniProt Secondary Accession #    Q62837; Q64032 [Other Products]
 UniProt Related Accession #    P49950 [Other Products]
 Molecular Weight    27kD [Similar Products]
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 NCBI Official Full Name    BCL-2, partial
 NCBI Official Synonym Full Names    B-cell CLL/lymphoma 2
 NCBI Official Symbol    Bcl2 [Similar Products]
 NCBI Official Synonym Symbols   
Bcl-2
[Similar Products]
 NCBI Protein Information    apoptosis regulator Bcl-2; Bcl2-like protein; B-cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene
 UniProt Protein Name    Apoptosis regulator Bcl-2
 Protein Family    Apoptosis regulator
 UniProt Gene Name    Bcl2 [Similar Products]
 UniProt Synonym Gene Names    Bcl-2 [Similar Products]
 UniProt Entry Name    BCL2_RAT
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 NCBI Summary for Bcl2    an anti-apoptotic protein; involved in inhibiting cell death in many different cell types [RGD, Feb 2006]
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 UniProt Comments for Bcl2    Bcl-2: a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions.

Protein type: Oncoprotein; Autophagy; Membrane protein, integral; Apoptosis

Cellular Component: endoplasmic reticulum membrane; nuclear membrane; mitochondrion; endoplasmic reticulum; cell; integral to membrane; cytosol; pore complex; mitochondrial outer membrane; membrane; cytoplasm; mitochondrial membrane; intracellular; nucleus; myelin sheath

Molecular Function: BH domain binding; identical protein binding; protein homodimerization activity; protease binding; protein phosphatase 2A binding; channel activity; channel inhibitor activity; protein phosphatase binding; transcription factor binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; ubiquitin protein ligase binding; BH3 domain binding

Biological Process: positive regulation of catalytic activity; focal adhesion formation; developmental growth; pigment granule organization and biogenesis; regulation of cell cycle; response to toxin; ear development; negative regulation of myeloid cell apoptosis; B cell receptor signaling pathway; regulation of protein localization; negative regulation of ossification; regulation of transmembrane transporter activity; oligodendrocyte differentiation; negative regulation of neuron apoptosis; kidney development; T cell differentiation; spleen development; response to drug; positive regulation of neuron maturation; axon regeneration; cell aging; regulation of calcium ion transport; positive regulation of cell growth; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; response to estrogen stimulus; response to heat; regulation of gene expression; negative regulation of osteoblast proliferation; response to oxidative stress; lymphocyte homeostasis; negative regulation of apoptosis; positive regulation of pigmentation; positive regulation of smooth muscle cell migration; response to L-ascorbic acid; response to insulin stimulus; response to organic substance; negative regulation of cell proliferation; positive regulation of skeletal muscle fiber development; ureteric bud development; positive regulation of cell proliferation; transmembrane transport; regulation of viral genome replication; negative regulation of cell migration; response to nutrient; response to aluminum ion; leukocyte homeostasis; aging; mesenchymal cell development; response to inorganic substance; CD8-positive, alpha-beta T cell lineage commitment; B cell lineage commitment; positive regulation of peptidyl-serine phosphorylation; response to UV-B; cell proliferation; peptidyl-serine phosphorylation; endoplasmic reticulum calcium ion homeostasis; response to copper ion; pigmentation; ureteric bud branching; homeostasis of number of cells within a tissue; response to hypoxia; brain development; negative regulation of cell growth; response to nicotine; renal system process; protein polyubiquitination; response to glucocorticoid stimulus; T cell differentiation in the thymus; lymphoid progenitor cell differentiation; positive regulation of multicellular organism growth; glomerulus development; response to organic cyclic substance; response to caffeine; post-embryonic development; cochlear nucleus development; regulation of apoptosis; cellular response to glucose starvation; cell-cell adhesion; regulation of mitochondrial membrane potential; response to folic acid; positive regulation of B cell proliferation; negative regulation of mitotic cell cycle; T cell homeostasis; response to electrical stimulus; cell growth; defense response to virus; response to corticosterone stimulus; release of cytochrome c from mitochondria; regulation of protein homodimerization activity; actin filament organization; digestive tract morphogenesis; organ growth; organ morphogenesis; induction of apoptosis via death domain receptors; response to steroid hormone stimulus; B cell differentiation; regulation of pigmentation during development; gland morphogenesis; regulation of mitochondrial membrane permeability; regulation of nitrogen utilization; metanephros development; oocyte development; B cell proliferation; response to peptide hormone stimulus; regulation of protein heterodimerization activity; response to cAMP; behavioral fear response; melanin metabolic process; apoptosis; negative regulation of retinal cell programmed cell death; regulation of cell-matrix adhesion; pigmentation during development; cell morphogenesis; regulation of protein stability; protein amino acid dephosphorylation; apoptotic mitochondrial changes; B cell homeostasis; ovarian follicle development; regulation of catalytic activity; positive regulation of melanocyte differentiation; melanocyte differentiation; response to gamma radiation; hemopoiesis; negative regulation of cellular pH reduction; response to iron ion; ossification; hair follicle morphogenesis; thymus development; male gonad development; peptidyl-threonine phosphorylation; regulation of programmed cell death; cellular calcium ion homeostasis; immune system development; T cell lineage commitment; neuron apoptosis; axonogenesis; response to hydrogen peroxide; response to cytokine stimulus; response to DNA damage stimulus; induction of apoptosis by oxidative stress; growth
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 Research Articles on Bcl2    1. RCAN1 induced the expression of the CREB target gene, Bcl-2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Bcl2 recombinant proteinPathways associated with Bcl2 recombinant protein
 Reference Product  PubMed Publications
 Bax recombinant protein  >1106 publications with Bcl2 and Bax
 Bad recombinant protein  >186 publications with Bcl2 and Bad
 Tp53 recombinant protein  >107 publications with Bcl2 and Tp53
 Bid recombinant protein  >95 publications with Bcl2 and Bid
 Bag1 recombinant protein  >50 publications with Bcl2 and Bag1
 Apaf1 recombinant protein  >38 publications with Bcl2 and Apaf1
 Akt1 recombinant protein  >30 publications with Bcl2 and Akt1
 Becn1 recombinant protein  >28 publications with Bcl2 and Becn1
 Bcl2l11 recombinant protein  >9 publications with Bcl2 and Bcl2l11
 Products by Pathway  Pathway Diagram
 ATM Pathway antibodies  ATM Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
Diseases associated with Bcl2 recombinant proteinOrgans/Tissues associated with Bcl2 recombinant protein
 Disease Name  Pubmed Publications
 Lymphoma, Non-Hodgkin Antibodies  >638 publications with Bcl2 and Lymphoma, Non-Hodgkin
 Carcinoma Antibodies  >562 publications with Bcl2 and Carcinoma
 Lymphoma, Follicular Antibodies  >342 publications with Bcl2 and Lymphoma, Follicular
 Necrosis Antibodies  >325 publications with Bcl2 and Necrosis
 Lymphoma, Large B-Cell, Diffuse Antibodies  >313 publications with Bcl2 and Lymphoma, Large B-Cell, Diffuse
 Breast Neoplasms Antibodies  >278 publications with Bcl2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >219 publications with Bcl2 and Adenocarcinoma
 Disease Progression Antibodies  >204 publications with Bcl2 and Disease Progression
 Inflammation Antibodies  >146 publications with Bcl2 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >129 publications with Bcl2 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Artery Antibodies  >59 publications with Bcl2 and Artery
 Uncharacterized Tissue Antibodies  >3 publications with Bcl2 and Uncharacterized Tissue
 Pituitary Gland Antibodies  >1 publications with Bcl2 and Pituitary Gland
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