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Add To Compare List BBC3 recombinant protein :: Bcl-2-binding component 3 (BBC3) Recombinant Protein Catalog # MBS1458132 Unit / Price 0.02 mg (E-Coli) / $700 +1 FREE 8GB USB 0.1 mg (E-Coli) / $840 +1 FREE 8GB USB 0.02 mg (Yeast) / $870 +1 FREE 8GB USB 0.1 mg (Yeast) / $1,020 +1 FREE 8GB USB 0.02 mg (Baculovirus) / $1,120 +1 FREE 8GB USB 0.02 mg (Mammalian-Cell) / $1,350 +1 FREE 8GB USB 1 mg (E-Coli) / $1,480 +1 FREE 8GB USB 0.1 mg (Baculovirus) / $1,555 +1 FREE 8GB USB 1 mg (Yeast) / $1,995 +2 FREE 8GB USB 0.1 mg (Mammalian-Cell) / $2,185 +2 FREE 8GB USB 1 mg (Baculovirus) / $3,055 +3 FREE 8GB USB 0.5 mg (Mammalian-Cell) / $5,820 +7 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Bcl-2-binding component 3 (BBC3), Recombinant Protein Full Product Name Recombinant Human Bcl-2-binding component 3 (BBC3) Product Gene Name BBC3 recombinant protein[Similar Products] Product Synonym Gene Name BBC3[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sequence Positions 1-193, Full length protein Sequence MARARQEGSS PEPVEGLARD GPRPFPLGRL VPSAVSCGLC EPGLAAAPAA PTLLPAAYLC APTAPPAVTA ALGGSRWPGG PRSRPRGPRP DGPQPSLSLA EQHLESPVPS APGALAGGPT QAAPGVRGEE EQWAREIGAQ LRRMADDLNA QYERRRQEEQ QRHRPSPWRV LYNLIMGLLP LPRGHRAPEM EPN OMIM 605854 3D Structure ModBase 3D Structure for Q9BXH1 Host E Coli or Yeast or Baculovirus or Mammalian Cell Purity/Purification Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific) Form/Format Lyophilized or liquid (Format to be determined during the manufacturing process) Tag Information This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information. Sterility Sterile filter available upon request. Endotoxin Low endotoxin available upon request. Species Human Preparation and Storage Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of BBC3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP NCBI/Uniprot data below describe general gene information for BBC3. It may not necessarily be applicable to this product. NCBI GI # 187829730 NCBI GeneID 27113 NCBI Accession # NP_001120712.1 [Other Products] NCBI GenBank Nucleotide # NM_001127240.2 [Other Products] UniProt Primary Accession # Q9BXH1 [Other Products] UniProt Secondary Accession # O00171; Q96PG9; B9EGI3[Other Products] UniProt Related Accession # Q96PG8; Q9BXH1[Other Products] Molecular Weight 10,326 Da TOP NCBI Official Full Name bcl-2-binding component 3 isoform 1 NCBI Official Synonym Full Names BCL2 binding component 3 NCBI Official Symbol BBC3 [Similar Products] NCBI Official Synonym Symbols JFY1; PUMA; JFY-1 [Similar Products] NCBI Protein Information bcl-2-binding component 3 UniProt Protein Name Bcl-2-binding component 3 UniProt Synonym Protein Names JFY-1; p53 up-regulated modulator of apoptosis Protein Family Bcl-2-binding component UniProt Gene Name BBC3 [Similar Products] UniProt Synonym Gene Names PUMA [Similar Products] TOP NCBI Summary for BBC3 This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] TOP UniProt Comments for BBC3 Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis. Research Articles on BBC3 1. Knockdown of Slug enhanced the antitumor activity of DOX in SW1736 cells via induction of PUMA upregulation. Our results suggest that targeting of Slug has good potential for the development of new therapeutic strategies for Anaplastic thyroid carcinoma. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with BBC3 recombinant protein Reference Product PubMed Publications PMAIP1 recombinant protein >73 publications with BBC3 and PMAIP1 TP53 recombinant protein >59 publications with BBC3 and TP53 BCL2L1 recombinant protein >46 publications with BBC3 and BCL2L1 BID recombinant protein >26 publications with BBC3 and BID BAD recombinant protein >24 publications with BBC3 and BAD MCL1 recombinant protein >17 publications with BBC3 and MCL1 SP1 recombinant protein >3 publications with BBC3 and SP1 SNAI2 recombinant protein >3 publications with BBC3 and SNAI2 BCL2L2 recombinant protein >3 publications with BBC3 and BCL2L2 Pathways associated with BBC3 recombinant protein Products by Pathway Pathway Diagram Activation Of BH3-only Proteins Pathway antibodies Activation Of BH3-only Proteins Pathway Diagram Activation Of PUMA And Translocation To Mitochondria Pathway antibodies Activation Of PUMA And Translocation To Mitochondria Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptosis Modulation And Signaling Pathway antibodies Apoptosis Modulation And Signaling Pathway Diagram BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway antibodies BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway Diagram DNA Damage Response Pathway antibodies DNA Damage Response Pathway Diagram DNA Damage Response (only ATM Dependent) Pathway antibodies DNA Damage Response (only ATM Dependent) Pathway Diagram Direct P53 Effectors Pathway antibodies Direct P53 Effectors Pathway Diagram Hippo Signaling Pathway antibodies Hippo Signaling Pathway Diagram Diseases associated with BBC3 recombinant protein Disease Name Pubmed Publications Carcinoma Antibodies >74 publications with BBC3 and Carcinoma Adenocarcinoma Antibodies >34 publications with BBC3 and Adenocarcinoma Breast Neoplasms Antibodies >32 publications with BBC3 and Breast Neoplasms Lung Neoplasms Antibodies >24 publications with BBC3 and Lung Neoplasms Necrosis Antibodies >20 publications with BBC3 and Necrosis Liver Diseases Antibodies >19 publications with BBC3 and Liver Diseases Lung Diseases Antibodies >17 publications with BBC3 and Lung Diseases Nervous System Diseases Antibodies >16 publications with BBC3 and Nervous System Diseases Inflammation Antibodies >13 publications with BBC3 and Inflammation Carcinoma, Squamous Cell Antibodies >13 publications with BBC3 and Carcinoma, Squamous Cell Organs/Tissues associated with BBC3 recombinant protein Organ/Tissue Name Pubmed Publications Lung Antibodies >30 publications with BBC3 and Lung Brain Antibodies >18 publications with BBC3 and Brain Kidney Antibodies >13 publications with BBC3 and Kidney Skin Antibodies >12 publications with BBC3 and Skin Prostate Antibodies >12 publications with BBC3 and Prostate Stomach Antibodies >12 publications with BBC3 and Stomach Muscle Antibodies >9 publications with BBC3 and Muscle Bone Antibodies >9 publications with BBC3 and Bone Eye Antibodies >7 publications with BBC3 and Eye Intestine Antibodies >6 publications with BBC3 and Intestine TOP © 2006-24 MyBioSource.com. 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