NP_001003940.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47.5 kDa
NCBI Official Full Name
bcl-2-modifying factor isoform bmf-1
NCBI Official Synonym Full Names
Bcl2 modifying factor
NCBI Protein Information
bcl-2-modifying factor
UniProt Protein Name
Bcl-2-modifying factor
UniProt Entry Name
BMF_HUMAN
NCBI Summary for BMF
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for BMF
BMF: May play a role in apoptosis. Isoform 1 seems to be the main initiator. Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2. Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Belongs to the Bcl-2 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal; Apoptosis
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: mitochondrial outer membrane; plasma membrane; acrosome; myosin complex; cytosol
Molecular Function: protein binding
Biological Process: apoptosis; positive regulation of protein homooligomerization; anoikis
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Products associated with BMF recombinant protein
Pathways associated with BMF recombinant protein
Diseases associated with BMF recombinant protein
Organs/Tissues associated with BMF recombinant protein
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