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Bax recombinant protein :: Bcl2 Associated X Protein (Bax) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2009171 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $265 +1 FREE 8GB USB
0.1 mg  /  $410 +1 FREE 8GB USB
0.2 mg  /  $500 +1 FREE 8GB USB
0.5 mg  /  $975 +1 FREE 8GB USB
1 mg  /  $1,440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bcl2 Associated X Protein (Bax), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Bcl2 Associated X Protein (Bax)

 Product Gene Name   

Bax recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF-MDGSGE QLGS GGPTSSEQIM KTGAFLLQGF IQDRAGRMAG ETPELTLEQP PQDASTKKLS ECLRRIGDEL DSNMELQRMI ADVDTDSPRE VFFRVAADMF ADGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLV WIQDQGGWEG LLSYFGTPTW QTVTIFVAGV LTASLTIWKK MG
 Chromosome Location    Chromosome: 7; NC_000073.6 (45461695..45466899, complement). Location: 7 B5; 7 29.32 cM
 3D Structure    ModBase 3D Structure for Q07813
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 Host    E Coli
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 Purity/Purification    > 90%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Mus musculus (Mouse)
 Expression System    Prokaryotic expression
 Residues    Met1~Gly192 (Accession # Q07813) with N-terminal His-Tag
 Subcellular Location    Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Predicted Isoelectric Point    5.5
 Reconstitution    Reconstitute in sterile ddH2O
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
 Supply Chain Verification    Manufactured in an a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of Bax recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Bax recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for Bax recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of Bax recombinant protein    Bax recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for Bax. It may not necessarily be applicable to this product.
 NCBI GI #    6680770
 NCBI GeneID    12028
 NCBI Accession #    NP_031553.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007527.3 [Other Products]
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 UniProt Primary Accession #    Q07813 [Other Products]
 UniProt Related Accession #    Q07813 [Other Products]
 Molecular Weight    22.9kDa
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 NCBI Official Full Name    apoptosis regulator BAX
 NCBI Official Synonym Full Names    BCL2-associated X protein
 NCBI Official Symbol    Bax [Similar Products]
 NCBI Protein Information    apoptosis regulator BAX
 UniProt Protein Name    Apoptosis regulator BAX
 Protein Family    Protein
 UniProt Gene Name    Bax [Similar Products]
 UniProt Entry Name    BAX_MOUSE
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 UniProt Comments for Bax    BAX: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells. Interacts with FAIM2/LFG2. Interacts with human cytomegalovirus/HHV-5 protein vMIA/UL37. Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. Belongs to the Bcl-2 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Apoptosis; Membrane protein, integral; Mitochondrial

Cellular Component: mitochondrial permeability transition pore complex; endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum; cell; integral to membrane; nuclear envelope; cytosol; pore complex; mitochondrial outer membrane; membrane; cytoplasm; mitochondrial membrane; intracellular; nucleus

Molecular Function: BH domain binding; identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; channel activity; heat shock protein binding; chaperone binding; BH3 domain binding; protein complex binding; lipid binding

Biological Process: hypothalamus development; regulation of cell cycle; positive regulation of apoptosis; response to toxin; germ cell programmed cell death; myeloid cell homeostasis; homeostasis of number of cells; B cell apoptosis; post-embryonic development; germ cell development; regulation of mammary gland epithelial cell proliferation; regulation of apoptosis; spermatid differentiation; development of secondary sexual characteristics; regulation of mitochondrial membrane potential; protein insertion into mitochondrial membrane during induction of apoptosis; regulation of neuron apoptosis; establishment and/or maintenance of transmembrane electrochemical gradient; negative regulation of neuron apoptosis; negative regulation of protein binding; kidney development; inner mitochondrial membrane organization and biogenesis; nervous system development; release of cytochrome c from mitochondria; outer mitochondrial membrane organization and biogenesis; positive regulation of B cell apoptosis; regulation of protein homodimerization activity; cellular respiration; vagina development; protein oligomerization; fertilization; induction of apoptosis via death domain receptors; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of fibroblast proliferation; retina development in camera-type eye; reduction of endoplasmic reticulum calcium ion concentration; glycosphingolipid metabolic process; cerebral cortex development; response to ionizing radiation; mitochondrial fragmentation during apoptosis; regulation of nitrogen utilization; post-embryonic camera-type eye morphogenesis; positive regulation of pigmentation; regulation of protein heterodimerization activity; T cell homeostatic proliferation; apoptosis; negative regulation of peptidyl-serine phosphorylation; positive regulation of apoptosis involved in mammary gland involution; neuron migration; regulation of caspase activity; release of matrix enzymes from mitochondria; response to salt stress; negative regulation of cell proliferation; positive regulation of protein oligomerization; apoptotic mitochondrial changes; B cell homeostatic proliferation; B cell homeostasis; ovarian follicle development; positive regulation of neuron apoptosis; response to wounding; response to gamma radiation; B cell negative selection; response to axon injury; transmembrane transport; protein homooligomerization; leukocyte homeostasis; caspase activation; mitochondrial fusion; transformed cell apoptosis; male gonad development; Sertoli cell proliferation; limb morphogenesis; odontogenesis of dentine-containing teeth; cell proliferation; neuron apoptosis; homeostasis of number of cells within a tissue; spermatogenesis; retinal cell programmed cell death; blood vessel remodeling; caspase activation via cytochrome c; positive regulation of release of sequestered calcium ion into cytosol; response to DNA damage stimulus; sex differentiation
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 Research Articles on Bax    1. Constitutive activation of proapoptotic Bax is a mechanism for rapid cell death preserved in medulloblastoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Bax recombinant proteinDiseases associated with Bax recombinant protein
 Products by Pathway  Pathway Diagram
 Activation, Translocation And Oligomerization Of BAX Pathway antibodies  Activation, Translocation And Oligomerization Of BAX Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Signaling Pathway antibodies  Apoptosis Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7513 publications with Bax and Neoplasms
 Necrosis Antibodies  >1808 publications with Bax and Necrosis
 Heart Diseases Antibodies  >1711 publications with Bax and Heart Diseases
 Nervous System Diseases Antibodies  >1657 publications with Bax and Nervous System Diseases
 Ischemia Antibodies  >1346 publications with Bax and Ischemia
 Brain Diseases Antibodies  >1231 publications with Bax and Brain Diseases
 Breast Neoplasms Antibodies  >856 publications with Bax and Breast Neoplasms
 Inflammation Antibodies  >845 publications with Bax and Inflammation
 Liver Diseases Antibodies  >834 publications with Bax and Liver Diseases
 Intestinal Neoplasms Antibodies  >760 publications with Bax and Intestinal Neoplasms
Organs/Tissues associated with Bax recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2882 publications with Bax and Blood
 Brain Antibodies  >2139 publications with Bax and Brain
 Heart Antibodies  >1954 publications with Bax and Heart
 Liver Antibodies  >1529 publications with Bax and Liver
 Lung Antibodies  >1155 publications with Bax and Lung
 Kidney Antibodies  >929 publications with Bax and Kidney
 Bone Antibodies  >706 publications with Bax and Bone
 Prostate Antibodies  >651 publications with Bax and Prostate
 Skin Antibodies  >474 publications with Bax and Skin
 Stomach Antibodies  >451 publications with Bax and Stomach
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