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BMF recombinant protein :: Bcl2 Modifying Factor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143605 BMF recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bcl2 Modifying Factor (BMF), Recombinant Protein

 Also Known As   

Recombinant Human Bcl2 Modifying Factor, Isoform 3

 Product Synonym Names    BMF Human; Bcl2 Modifying Factor, Isoform 3 Human Recombinant; Bcl-2-modifying factor; FLJ00065; BMF
 Product Gene Name   

BMF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MASMTGGQQM GRGSHMEPSQ CVEELEDDVF QPEDGEPVTQ PGSLLSADLF AQSLLDCPLS RLQLFPLTHC CGPGLRPTSQ EDKATQTLSP ASPSQGVMLP CGVTEEPQRL FYAPAEPKSC VVADPPLPAQ PCFEWRREQE RGRP
 OMIM    606266
 3D Structure    ModBase 3D Structure for Q96LC9
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The Bcl2 modifying factor solution contains 20mM Tris pH-7.5, 1mM DTT & 10% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    Bcl2 modifying factor although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of BMF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BMF recombinant protein

   Description: Bcl2 modifying factor Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 144 amino acids (1-129 a.a.) and having a molecular mass of 15.6 kDa.The Bcl2 modifying factor is fused to 15 amino acid His Tag at Nterminus and purified by proprietary chromatographic techniques.

Introduction: Bcl2 modifying factor, is a member of the Bcl2 protein family of apoptosis mediators. Bcl2 modifying factor is widely expressed in many tissues. Bcl2 modifying factor contains a single Bcl2 homology domain 3 (BH3), and binds Bcl2 proteins and functions as an apoptotic activator. Also, Bcl2 modifying factor is important for histone deacetylase (HDAC) inhibitors which alters the balance between acetylation and deacetylation, significantly increasing histone acetylation, while strongly inducing apoptosis in a variety of cancer cell types. Bcl2 modifying factor supports Bim in regulating cell death processes in response to many stimuli. A synergistic role for bim and Bcl2 modifying factor in an apoptotic pathway leading to the clearance of Neisseria gonorrhoeae -infected cells.
 Product Categories/Family for BMF recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for BMF. It may not necessarily be applicable to this product.
 NCBI GI #    51558688
 NCBI GeneID    90427
 NCBI Accession #    NP_001003940.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001003940.1 [Other Products]
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 UniProt Primary Accession #    Q96LC9 [Other Products]
 UniProt Secondary Accession #    Q2M396; Q6NT30; Q6NT56; Q6P9F6; Q7Z7D4; Q7Z7D5; Q9H7K7 [Other Products]
 UniProt Related Accession #    Q96LC9 [Other Products]
 Molecular Weight    14,150 Da
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 NCBI Official Full Name    bcl-2-modifying factor isoform bmf-1
 NCBI Official Synonym Full Names    Bcl2 modifying factor
 NCBI Official Symbol    BMF [Similar Products]
 NCBI Protein Information    bcl-2-modifying factor
 UniProt Protein Name    Bcl-2-modifying factor
 Protein Family    Bcl-2-modifying factor
 UniProt Gene Name    BMF [Similar Products]
 UniProt Entry Name    BMF_HUMAN
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 NCBI Summary for BMF    The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BMF    BMF: May play a role in apoptosis. Isoform 1 seems to be the main initiator. Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2. Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Belongs to the Bcl-2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Apoptosis

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: mitochondrial outer membrane; acrosome; plasma membrane; cytosol; myosin complex

Molecular Function: protein binding

Biological Process: apoptosis; positive regulation of protein homooligomerization; anoikis
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 Research Articles on BMF    1. Overexpression of ApoL2 did not induce cell death on its own. ApoL2 did not sensitize or protect cells from overexpression of the BH3-only proteins Bmf or Noxa.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMF recombinant proteinPathways associated with BMF recombinant protein
 Reference Product  PubMed Publications
 BCL2 recombinant protein  >19 publications with BMF and BCL2
 BIK recombinant protein  >15 publications with BMF and BIK
 BCL2L1 recombinant protein  >11 publications with BMF and BCL2L1
 HRK recombinant protein  >8 publications with BMF and HRK
 BCL2L11 recombinant protein  >5 publications with BMF and BCL2L11
 MCL1 recombinant protein  >5 publications with BMF and MCL1
 BCL2L2 recombinant protein  >4 publications with BMF and BCL2L2
 MAPK8 recombinant protein  >3 publications with BMF and MAPK8
 DYNLL2 recombinant protein  >2 publications with BMF and DYNLL2
 MYO5A recombinant protein  >1 publications with BMF and MYO5A
 Products by Pathway  Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation Of BMF And Translocation To Mitochondria Pathway antibodies  Activation Of BMF And Translocation To Mitochondria Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway antibodies  BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway Diagram
 Intrinsic Pathway For Apoptosis antibodies  Intrinsic Pathway For Apoptosis Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram
Diseases associated with BMF recombinant proteinOrgans/Tissues associated with BMF recombinant protein
 Disease Name  Pubmed Publications
 Anemia Antibodies  >48 publications with BMF and Anemia
 Carcinoma Antibodies  >19 publications with BMF and Carcinoma
 Fibrosis Antibodies  >16 publications with BMF and Fibrosis
 Liver Diseases Antibodies  >12 publications with BMF and Liver Diseases
 Neoplasms, Experimental Antibodies  >10 publications with BMF and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >9 publications with BMF and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >9 publications with BMF and Cardiovascular Diseases
 Necrosis Antibodies  >9 publications with BMF and Necrosis
 Breast Neoplasms Antibodies  >8 publications with BMF and Breast Neoplasms
 Leukemia, Lymphocytic, Chronic, B-Cell Antibodies  >8 publications with BMF and Leukemia, Lymphocytic, Chronic, B-Cell
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >111 publications with BMF and Bone
 Blood Antibodies  >106 publications with BMF and Blood
 Liver Antibodies  >32 publications with BMF and Liver
 Brain Antibodies  >27 publications with BMF and Brain
 Vascular Antibodies  >14 publications with BMF and Vascular
 Connective Tissue Antibodies  >13 publications with BMF and Connective Tissue
 Skin Antibodies  >9 publications with BMF and Skin
 Kidney Antibodies  >7 publications with BMF and Kidney
 Thyroid Antibodies  >6 publications with BMF and Thyroid
 Lung Antibodies  >5 publications with BMF and Lung
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