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ATG14 recombinant protein :: Beclin 1-associated autophagy-related key regulator (ATG14) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1449868
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $915 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $990 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,120 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,220 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,340 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,350 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,370 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,420 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,515 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,915 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,040 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,070 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,310 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,680 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Beclin 1-associated autophagy-related key regulator (ATG14), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Beclin 1-associated autophagy-related key regulator (ATG14)

 Product Synonym Names    Beclin 1-associated autophagy-related key regulator; Barkor; Autophagy-related protein 14-like protein; Atg14L
 Product Gene Name   

ATG14 recombinant protein

[Similar Products]
 Product Synonym Gene Name    ATG14; KIAA0831 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1449868 COA    COA PDF
 Sequence Positions    1-492aa; Full Length
 Sequence    MASPSGKGAR ALEAPGCGPR PLARDLVDSV DDAEGLYVAV ERCPLCNTTR RRLTCAKCVQ SGDFVYFDGR DRERFIDKKE RLSRLKSKQE EFQKEVLKAM EGKWITDQLR WKIMSCKMRI EQLKQTICKG NEEMEKNSEG LLKTKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT IDLRSHYERL ANLRRSHILE LTSVIFPIEE VKTGVRDPAD VSSESDSAMT SSTVSKLAEA RRTTYLSGRW VCDDHNGDTS ISITGPWISL PNNGDYSAYY SWVEEKKTTQ GPDMEQSNPA YTISAALCYA TQLVNILSHI LDVNLPKKLC NSEFCGENLS KQKFTRAVKK LNANILYLCF SQHVNLDQLQ PLHTLRNLMY LVSPSSEHLG RSGPFEVRAD LEESMEFVDP GVAGESDESG DERVSDEETD LGTDWENLPS PRFCDIPSQS VEVSQSQSTQ ASPPIASSSA GGMISSAAAS VTSWFKAYTG HR
 OMIM    613515
 3D Structure    ModBase 3D Structure for Q6ZNE5
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ATG14 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ATG14 recombinant protein

   Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).
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 SDS-Page of ATG14 recombinant protein    ATG14 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for ATG14. It may not necessarily be applicable to this product.
 NCBI GI #    50540545
 NCBI GeneID    22863
 NCBI Accession #    NP_055739.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_014924.4 [Other Products]
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 UniProt Primary Accession #    Q6ZNE5 [Other Products]
 UniProt Secondary Accession #    O94920; Q32MK7; Q32MK8; A6NJE4; A8K9U5; B7ZWP5 [Other Products]
 UniProt Related Accession #    Q6ZNE5 [Other Products]
 Molecular Weight    42,434 Da
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 NCBI Official Full Name    beclin 1-associated autophagy-related key regulator
 NCBI Official Synonym Full Names    autophagy related 14
 NCBI Official Symbol    ATG14 [Similar Products]
 NCBI Official Synonym Symbols   
ATG14L; BARKOR; KIAA0831
[Similar Products]
 NCBI Protein Information    beclin 1-associated autophagy-related key regulator; Beclin 1-Interacting protein; ATG14 autophagy related 14 homolog; autophagy-related protein 14-like protein
 UniProt Protein Name    Beclin 1-associated autophagy-related key regulator
 UniProt Synonym Protein Names   
Autophagy-related protein 14-like protein; Atg14L
 Protein Family    Beclin 1-associated autophagy-related key regulator
 UniProt Gene Name    ATG14 [Similar Products]
 UniProt Synonym Gene Names    KIAA0831; Barkor; Atg14L [Similar Products]
 UniProt Entry Name    BAKOR_HUMAN
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 UniProt Comments for ATG14    Barkor: Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Forms a complex with BECN1, PIK3C3 and PIK3R4, but not with UVRAG, nor with KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through direct competition. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy. Interacts with PIK3CB. Belongs to the Barkor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy

Chromosomal Location of Human Ortholog: 14q22.3

Cellular Component: nucleoplasm; cytoplasm; pre-autophagosomal structure membrane; autophagic vacuole; axoneme; phagocytic vesicle; nucleus

Molecular Function: protein binding

Biological Process: regulation of protein amino acid phosphorylation; macroautophagy; mitochondrion degradation; endosome to lysosome transport; positive regulation of autophagy; autophagic vacuole formation
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 Research Articles on ATG14    1. Cisplatin upregulated Barkor protein levels of the Saos-2 cell line.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ATG14 recombinant proteinDiseases associated with ATG14 recombinant protein
 Products by Pathway  Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3 publications with ATG14 and Kidney Diseases
 Disease Models, Animal Antibodies  >2 publications with ATG14 and Disease Models, Animal
 Nervous System Diseases Antibodies  >2 publications with ATG14 and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with ATG14 and Brain Diseases
 Inflammation Antibodies  >1 publications with ATG14 and Inflammation
 Atrophy Antibodies  >1 publications with ATG14 and Atrophy
 Necrosis Antibodies  >1 publications with ATG14 and Necrosis
Organs/Tissues associated with ATG14 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >6 publications with ATG14 and Kidney
 Liver Antibodies  >2 publications with ATG14 and Liver
 Embryonic Tissue Antibodies  >1 publications with ATG14 and Embryonic Tissue
 Intestine Antibodies  >1 publications with ATG14 and Intestine
 Heart Antibodies  >1 publications with ATG14 and Heart
 Muscle Antibodies  >1 publications with ATG14 and Muscle
 Brain Antibodies  >1 publications with ATG14 and Brain
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