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B2M recombinant protein :: Beta-2-microglobulin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717104 B2M recombinant protein
Unit / Price
0.01 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $220 +1 FREE 8GB USB
0.2 mg  /  $770 +1 FREE 8GB USB
1 mg  /  $2,100 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Beta-2-microglobulin (B2M), Recombinant Protein

 Also Known As   

Recombinant human Beta-2-microglobulin protein

 Product Gene Name   

B2M recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    QRTPKIQVYS RHPAENGKSN FLNCYVSGFH PSDIEVDLLK NGERIEKVEH SDLSFSKDWS FYLLYYTEFT PTEKDEYACR VNHVTLSQPK IVKWDR
 Chromosome Location    Chromosome: 15; NC_000015.9 (45003685..45010357). Location: 15q21-q22.2
 OMIM    109700
 3D Structure    ModBase 3D Structure for P61769
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 Purity/Purification    95% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store working aliquots at 4 degree C for up to one week. For extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of B2M recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for B2M recombinant protein

   Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
 Applications Tested/Suitable for B2M recombinant protein   

ELISA, Western Blot

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NCBI/Uniprot data below describe general gene information for B2M. It may not necessarily be applicable to this product.
 NCBI GI #    179318
 NCBI GeneID    567
 NCBI Accession #    AAA51811.1 [Other Products]
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 UniProt Primary Accession #    P61769 [Other Products]
 UniProt Secondary Accession #    P01884; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4 [Other Products]
 UniProt Related Accession #    P61769; Q16446; Q9UM88 [Other Products]
 Molecular Weight    15 KD [Similar Products]
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 NCBI Official Full Name    beta-2-microglobulin
 NCBI Official Synonym Full Names    beta-2-microglobulin
 NCBI Official Symbol    B2M [Similar Products]
 NCBI Protein Information    beta-2-microglobulin; OTTHUMP00000161912; beta-2-microglobin; beta chain of MHC class I molecules
 UniProt Protein Name    Beta-2-microglobulin
 Protein Family    Beta-2-microglobulin
 UniProt Gene Name    B2M [Similar Products]
 UniProt Entry Name    B2MG_HUMAN
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 NCBI Summary for B2M    This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009]
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 UniProt Comments for B2M    Function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.Subunit structure: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Ref.14Subcellular location: Secreted. Note: Detected in serum and urine. Ref.16 Ref.17Post-translational modification: Glycation of Ile-21 is observed in long-term hemodialysis patients.Involvement in disease: Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. Ref.33Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32Sequence similarities: Belongs to the beta-2-microglobulin family.Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
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Product References and Citations for B2M recombinant protein

   [1] "The beta-2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon." Rosa F., Berissi H., Weissenbach J., Maroteaux L., Fellous M., Revel M. EMBO J. 2:239-243(1983)
[2] "Isolation of a granulocyte inhibitory protein from uraemic patients with homology of beta 2-microglobulin." Haag-Weber M., Mai B., Hoerl W.H. Nephrol. Dial. Transplant. 9:382-388(1994)
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 Research Articles on B2M    1. Beta2-microglobulin is recognized as a surrogate marker of middle-molecule uraemic toxins and represents a key component of dialysis-associated amyloidosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with B2M recombinant proteinPathways associated with B2M recombinant protein
 Reference Product  PubMed Publications
 HLA-A recombinant protein  >10 publications with B2M and HLA-A
 HLA-B recombinant protein  >8 publications with B2M and HLA-B
 HLA-G recombinant protein  >4 publications with B2M and HLA-G
 HLA-C recombinant protein  >2 publications with B2M and HLA-C
 HFE recombinant protein  >2 publications with B2M and HFE
 HLA-E recombinant protein  >1 publications with B2M and HLA-E
 FCGRT recombinant protein  >1 publications with B2M and FCGRT
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
Diseases associated with B2M recombinant proteinOrgans/Tissues associated with B2M recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >148 publications with B2M and Neoplasms
 Male Urogenital Diseases Antibodies  >76 publications with B2M and Male Urogenital Diseases
 Female Urogenital Diseases Antibodies  >71 publications with B2M and Female Urogenital Diseases
 Kidney Diseases Antibodies  >53 publications with B2M and Kidney Diseases
 Leukemia Antibodies  >42 publications with B2M and Leukemia
 Lymphoma Antibodies  >26 publications with B2M and Lymphoma
 Proteinuria Antibodies  >21 publications with B2M and Proteinuria
 Renal Insufficiency Antibodies  >20 publications with B2M and Renal Insufficiency
 Inflammation Antibodies  >19 publications with B2M and Inflammation
 Liver Diseases Antibodies  >15 publications with B2M and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >211 publications with B2M and Blood
 Kidney Antibodies  >78 publications with B2M and Kidney
 Bone Antibodies  >56 publications with B2M and Bone
 Bone Marrow Antibodies  >43 publications with B2M and Bone Marrow
 Liver Antibodies  >30 publications with B2M and Liver
 Skin Antibodies  >22 publications with B2M and Skin
 Heart Antibodies  >19 publications with B2M and Heart
 Brain Antibodies  >18 publications with B2M and Brain
 Muscle Antibodies  >17 publications with B2M and Muscle
 Spleen Antibodies  >14 publications with B2M and Spleen
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