NP_035993.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,794 Da
NCBI Official Full Name
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform a
NCBI Official Synonym Full Names
3'-phosphoadenosine 5'-phosphosulfate synthase 1
NCBI Protein Information
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
UniProt Protein Name
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
UniProt Synonym Protein Names
3'-phosphoadenosine-5'-phosphosulfate synthase; APS kinase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylylsulfate 3'-phosphotransferase
UniProt Synonym Gene Names
UniProt Comments for Papss1
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:7493984). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells ().
Research Articles on Papss1
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Pathways associated with Papss1 recombinant protein
Diseases associated with Papss1 recombinant protein
Organs/Tissues associated with Papss1 recombinant protein
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