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Gne recombinant protein :: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (Gne) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1063044 Gne recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,155 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,300 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,555 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,555 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,605 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,650 +2 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,720 +2 FREE 8GB USB
0.5 mg (Yeast)  /  $1,820 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,335 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,355 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,445 +3 FREE 8GB USB
1 mg (Yeast)  /  $2,745 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $3,085 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (Gne), Recombinant Protein

 Also Known As   

Recombinant Rat Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (Gne)

 Product Gene Name   

Gne recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-722aa, Full length protein
 Sequence    MEKNGNNRKL RVCVATCNRA DYSKLAPIMF GIKTEPAFFE LDVVVLGSHL IDDYGNTYRM IEQDDFDINT RLHTIVRGED EAAMVESVGL ALVKLPDVLN RLKPDIMIVH GDRFDALALA TSAALMNIRI LHIEGGEVSG TIDDSIRHAI TKLAHYHVCC TRSAEQHLIS MCEDHDRILL AGCPSYDKLL SAKNKDYMSI IRMWLGDDVK CKDYIVALQH PVTTDIKHSI KMFELTLDAL ISFNKRTLVL FPNIDAGSKE MVRVMRKKGI EHHPNFRAVK HVPFDQFIQL VAHAGCMIGN SSCGVREVGA FGTPVINLGT RQIGRETGEN VLHVRDADTQ DKILQALHLQ FGKQYPCSKI YGDGNAVPRI LKFLKSIDLQ EPLQKKFCFP PVKENISQDI DHILETLSAL AVDLGGTNLR VAIVSMKGEI VKKYTQFNPK TYEERISLIL QMCVEAAAEA VKLNCRILGV GISTGGRVNP QEGVVLHSTK LIQEWNSVDL RTPLSDTLHL PVWVDNDGNC AAMAERKFGQ GKGQENFVTL ITGTGIGGGI IHQHELIHGS SFCAAELGHL VVSLDGPDCS CGSHGCIEAY ASGMALQREA KKLHDEDLLL VEGMSVPKDE AVGALHLIQA AKLGNVKAQS ILRTAGTALG LGVVNILHTM NPSLVILSGV LASHYIHIVR DVIRQQALSS VQDVDVVVSD LVDPALLGAA SMVLDYTTRR IH
 3D Structure    ModBase 3D Structure for O35826
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rat
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Gne recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Gne recombinant protein

   This protein is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.
NCBI/Uniprot data below describe general gene information for Gne. It may not necessarily be applicable to this product.
 NCBI GI #    16758602
 NCBI GeneID    114711
 NCBI Accession #    NP_446217.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053765.2 [Other Products]
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 UniProt Primary Accession #    O35826 [Other Products]
 UniProt Related Accession #    O35826 [Other Products]
 Molecular Weight    79,227 Da
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 NCBI Official Full Name    bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
 NCBI Official Synonym Full Names    glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
 NCBI Official Symbol    Gne [Similar Products]
 NCBI Official Synonym Symbols   
Uae1
[Similar Products]
 NCBI Protein Information    bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
 UniProt Protein Name    Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
 UniProt Synonym Protein Names   
UDP-GlcNAc-2-epimerase/ManAc kinaseIncluding the following 2 domains:UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC:3.2.1.183)Alternative name(s):UDP-GlcNAc-2-epimerase; Uridine diphosphate-N-acetylglucosamine-2-epimerase
 Protein Family    Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
 UniProt Gene Name    Gne [Similar Products]
 UniProt Synonym Gene Names    Glcne [Similar Products]
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 NCBI Summary for Gne    bifunctional enzyme, catalyzes the first two steps of biosynthesis of Neu5Ac (UDP-GlcNAc 2-epimerase and ManNAc kinase), precursor of sialic acids [RGD, Feb 2006]
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 UniProt Comments for Gne    Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Plays an essential role in early development ().
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 Research Articles on Gne    1. M712T mutation of GNE gene does not affect GNE oligomerization but affects the solubility and posttranslational modification of the GNE protein.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Gne recombinant proteinPathways associated with Gne recombinant protein
 Reference Product  PubMed Publications
 Renbp recombinant protein  >3 publications with Gne and Renbp
 Products by Pathway  Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 CMP-N-acetylneuraminate Biosynthesis I (eukaryotes) Pathway antibodies  CMP-N-acetylneuraminate Biosynthesis I (eukaryotes) Pathway Diagram
 Superpathway Of Sialic Acid And CMP-sialic Acid Biosynthesis antibodies  Superpathway Of Sialic Acid And CMP-sialic Acid Biosynthesis Diagram
Diseases associated with Gne recombinant proteinOrgans/Tissues associated with Gne recombinant protein
 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >83 publications with Gne and Muscular Diseases
 Myositis, Inclusion Body Antibodies  >44 publications with Gne and Myositis, Inclusion Body
 Neurologic Manifestations Antibodies  >13 publications with Gne and Neurologic Manifestations
 Brain Diseases Antibodies  >7 publications with Gne and Brain Diseases
 Neoplasms Antibodies  >7 publications with Gne and Neoplasms
 Inflammation Antibodies  >5 publications with Gne and Inflammation
 Sialic Acid Storage Disease Antibodies  >5 publications with Gne and Sialic Acid Storage Disease
 Proteinuria Antibodies  >4 publications with Gne and Proteinuria
 Drug Toxicity Antibodies  >4 publications with Gne and Drug Toxicity
 Cardiovascular Diseases Antibodies  >3 publications with Gne and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with Gne and Brain
 Kidney Antibodies  >7 publications with Gne and Kidney
 Liver Antibodies  >5 publications with Gne and Liver
 Ovary Antibodies  >4 publications with Gne and Ovary
 Connective Tissue Antibodies  >3 publications with Gne and Connective Tissue
 Placenta Antibodies  >2 publications with Gne and Placenta
 Adipose Tissue Antibodies  >2 publications with Gne and Adipose Tissue
 Colon Antibodies  >1 publications with Gne and Colon
 Prostate Antibodies  >1 publications with Gne and Prostate
 Uncharacterized Tissue Antibodies  >1 publications with Gne and Uncharacterized Tissue
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