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BLVRA recombinant protein :: Biliverdin Reductase A Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143538 BLVRA recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,800 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Biliverdin Reductase A (BLVRA), Recombinant Protein

 Also Known As   

Recombinant Human Biliverdin Reductase A

 Product Synonym Names    BLVRA Human; Biliverdin Reductase A Human Recombinant; Biliverdin reductase A; BVR A; Biliverdin-IX alpha-reductase; BLVRA; BLVR; BVR; BVRA
 Product Gene Name   

BLVRA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MAEPERKFGV VVVGVGRAGS VRMRDLRNPH PSSAFLNLIG FVSRRELGSI DGVQQISLED ALSSQEVEVA YICSESSSHE DYIRQFLNAG KHVLVEYPMT LSLAAAQELW ELAEQKGKVL HEEHVELLME EFAFLKKEVV GKDLLKGSLL FTAGPLEEER FGFPAFSGIS RLTWLVSLFG ELSLVSATLE ERKEDQYMKM TVCLETEKKS PLSWIEEKGP GLKRNRYLSF HFKSGSLENV PNVGVNKNIF LKDQNIFVQK LLGQFSEKEL AAEKKRILHC LGLAEEIQKY CCSRK
 OMIM    109750
 3D Structure    ModBase 3D Structure for P53004
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The BLVRA solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Sterile Filtered colorless solution.
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 Other Notes    Small volumes of BLVRA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BLVRA recombinant protein

   Description: BLVRA Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 295 amino acids (3-296 a.a. and Methionine at N-terminus) and having a molecular mass of 33.3kDa (molecular weight on SDS-PAGE will shift up).The BLVRA is purified by proprietary chromatographic techniques.

Introduction: Biliverdin reductase A (BLVRA) is a member of the gfo/idh/mocA family. BLVRA is an enzyme that converts biliverdin to bilirubin, converting a double-bond between the second and third pyrrole ring into a single-bond. BLVRA reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the simultaneous oxidation of a NADH or NADPH cofactor (Bilirubin + NAD(P)+ = biliverdin + NAD(P)H).BLVRA is a regulator for induction of activating transcription factor-2 and heme oxygenase-1. Furthermore, BLVRA enhances the role of HO-1 in cytoprotection and provides cytoprotection independent of heme degradation. In addition, Bilirubin while acting as a cytoprotective antioxidant is itself oxidized to biliverdin and subsequently recycled by biliverdin reductase back to bilirubin.
 Product Categories/Family for BLVRA recombinant protein    ENZYMES; Enzymes; Reductase
NCBI/Uniprot data below describe general gene information for BLVRA. It may not necessarily be applicable to this product.
 NCBI GI #    33589854
 NCBI GeneID    644
 NCBI Accession #    NP_000703.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000712.3 [Other Products]
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 UniProt Primary Accession #    P53004 [Other Products]
 UniProt Secondary Accession #    O95019; Q86UX0; Q96QL4; Q9BRW8; A8K747 [Other Products]
 UniProt Related Accession #    P53004 [Other Products]
 Molecular Weight    33,428 Da
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 NCBI Official Full Name    biliverdin reductase A
 NCBI Official Synonym Full Names    biliverdin reductase A
 NCBI Official Symbol    BLVRA [Similar Products]
 NCBI Official Synonym Symbols   
BVR; BLVR; BVRA
[Similar Products]
 NCBI Protein Information    biliverdin reductase A; BVR A; biliverdin-IX alpha-reductase
 UniProt Protein Name    Biliverdin reductase A
 UniProt Synonym Protein Names   
Biliverdin-IX alpha-reductase
 Protein Family    Biliverdin reductase
 UniProt Gene Name    BLVRA [Similar Products]
 UniProt Synonym Gene Names    BLVR; BVR; BVR A [Similar Products]
 UniProt Entry Name    BIEA_HUMAN
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 NCBI Summary for BLVRA    The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for BLVRA    BVR: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Monomer. Liver. Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.

Protein type: Kinase, protein; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor); EC 1.3.1.24; ATYPICAL group; BLVRA family

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: cytosol

Molecular Function: zinc ion binding; biliverdin reductase activity

Biological Process: heme catabolic process; porphyrin metabolic process

Disease: Hyperbiliverdinemia
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 Research Articles on BLVRA    1. Interactions of HO-2 with CPR and BVR, were evaluated.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BLVRA recombinant proteinPathways associated with BLVRA recombinant protein
 Reference Product  PubMed Publications
 HMOX1 recombinant protein  >5 publications with BLVRA and HMOX1
 UGT1A1 recombinant protein  >2 publications with BLVRA and UGT1A1
 HMOX2 recombinant protein  >1 publications with BLVRA and HMOX2
 Products by Pathway  Pathway Diagram
 Heme Degradation Pathway antibodies  Heme Degradation Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Porphyrins Pathway antibodies  Metabolism Of Porphyrins Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Heme Degradation Pathway antibodies  Heme Degradation Pathway Diagram
 Heme Degradation Pathway antibodies  Heme Degradation Pathway Diagram
Diseases associated with BLVRA recombinant proteinOrgans/Tissues associated with BLVRA recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with BLVRA and Inflammation
 Heart Diseases Antibodies  >2 publications with BLVRA and Heart Diseases
 Jaundice Antibodies  >1 publications with BLVRA and Jaundice
 Edema Antibodies  >1 publications with BLVRA and Edema
 Hypertension Antibodies  >1 publications with BLVRA and Hypertension
 Brain Diseases Antibodies  >1 publications with BLVRA and Brain Diseases
 Liver Diseases Antibodies  >1 publications with BLVRA and Liver Diseases
 Cholestasis Antibodies  >1 publications with BLVRA and Cholestasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with BLVRA and Blood
 Liver Antibodies  >2 publications with BLVRA and Liver
 Heart Antibodies  >1 publications with BLVRA and Heart
 Skin Antibodies  >1 publications with BLVRA and Skin
 Brain Antibodies  >1 publications with BLVRA and Brain
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