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BMP4 recombinant protein :: Bone Morphogenetic Protein 4, 293-408aa Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS650655 BMP4 recombinant protein
Unit / Price
0.1 mg  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bone Morphogenetic Protein 4, 293-408aa (BMP4), Recombinant Protein

 Also Known As   

Bone Morphogenetic Protein 4, 293-408aa, Recombinant, Human (BMP4, DVR4)

 Product Gene Name   

BMP4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSPKHHSQRA RKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI
SMLYLD EYDK VVLKNYQEMV VEGCGCR
 Chromosome Location    Chromosome: 14; NC_000014.8 (54416454..54423554, complement). Location: 14q22-q23
 OMIM    112262
 3D Structure    ModBase 3D Structure for P12644
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 Host    E Coli
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 Purity/Purification    Highly Purified
95% by SDS-PAGE
 Form/Format    Supplied as a liquid in 10mM sodium citrate buffer, pH 3.5, 10% glycerol.
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 Endotoxin Level    1.0 EU per 1 ug of protein (determined by LAL method)15% SDS-PAGE (3ug)
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 Preparation and Storage    For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of BMP4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for BMP4 recombinant protein

   Bone morphogenetic protein 4 (BMP-4) is a member of the bone morphogenetic protein family which belongs to the TGF- superfamily. This protein is a vital regulatory molecule that functions throughout bone and cartilage development, specifically tooth development, limb formation, bone induction, and fracture repair. In human embryonic development, BMP- 4 is required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. And it is overexpressed in patients with fibrodysplasia ossificans progressiva. Recombinant BMP-4 was expressed as insoluble protein aggregate in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
 Product Categories/Family for BMP4 recombinant protein    Growth Factors, Cytokines; Growth Factors-BMP
NCBI/Uniprot data below describe general gene information for BMP4. It may not necessarily be applicable to this product.
 NCBI GI #    1311542
 NCBI GeneID    652
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 UniProt Primary Accession #    P12644 [Other Products]
 UniProt Secondary Accession #    Q9UM80 [Other Products]
 UniProt Related Accession #    P12644; Q53XC5 [Other Products]
 Molecular Weight    13.2kD (117 aa) [Similar Products]
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 NCBI Official Full Name    bone morphogenetic protein 4
 NCBI Official Synonym Full Names    bone morphogenetic protein 4
 NCBI Official Symbol    BMP4 [Similar Products]
 NCBI Official Synonym Symbols   
ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein 4; BMP-4; BMP-2B; OTTHUMP00000178992; bone morphogenetic protein 2B
 UniProt Protein Name    Bone morphogenetic protein 4
 UniProt Synonym Protein Names   
Bone morphogenetic protein 2B
 Protein Family    Bone morphogenetic protein
 UniProt Gene Name    BMP4 [Similar Products]
 UniProt Synonym Gene Names    BMP2B; DVR4 [Similar Products]
 UniProt Entry Name    BMP4_HUMAN
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 NCBI Summary for BMP4    The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq]
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 UniProt Comments for BMP4    Function: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction

Subunit structure: Homodimer; disulfide-linked

By similarity. Interacts with GREM2

By similarity and SOSTDC1. Part of a complex consisting of TWSG1 and CHRD

By similarity. Ref.5

Subcellular location: Secreted › extracellular space › extracellular matrix.

Tissue specificity: Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.

Involvement in disease: Defects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6) [

MIM:607932]; also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS6 is characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies. Ref.7Defects in BMP4 are the cause of non-syndromic orofacial cleft type 11 (OFC11) [

MIM:600625]. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC11 is an unusual anomaly consisting of a paramedian scar of the upper lip with an appearance suggesting that a typical cleft lip was corrected in utero. Ref.9

Sequence similarities: Belongs to the TGF-beta family.
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 Research Articles on BMP4    1. Bone morphogenetic protein 4 mediates human embryonic germ cell derivation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMP4 recombinant proteinPathways associated with BMP4 recombinant protein
 Reference Product  PubMed Publications
 BMPR2 recombinant protein  >114 publications with BMP4 and BMPR2
 BMPR1A recombinant protein  >110 publications with BMP4 and BMPR1A
 BMPR1B recombinant protein  >22 publications with BMP4 and BMPR1B
 NOG recombinant protein  >16 publications with BMP4 and NOG
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Glypican 3 Network Pathway antibodies  Glypican 3 Network Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with BMP4 recombinant proteinOrgans/Tissues associated with BMP4 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >156 publications with BMP4 and Neoplasms
 Bone Diseases Antibodies  >151 publications with BMP4 and Bone Diseases
 Congenital Abnormalities Antibodies  >151 publications with BMP4 and Congenital Abnormalities
 Cardiovascular Diseases Antibodies  >65 publications with BMP4 and Cardiovascular Diseases
 Craniofacial Abnormalities Antibodies  >56 publications with BMP4 and Craniofacial Abnormalities
 Leukemia Antibodies  >45 publications with BMP4 and Leukemia
 Vascular Diseases Antibodies  >42 publications with BMP4 and Vascular Diseases
 Heart Diseases Antibodies  >35 publications with BMP4 and Heart Diseases
 Central Nervous System Diseases Antibodies  >33 publications with BMP4 and Central Nervous System Diseases
 Hypertension Antibodies  >32 publications with BMP4 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2015 publications with BMP4 and Bone
 Embryonic Tissue Antibodies  >559 publications with BMP4 and Embryonic Tissue
 Brain Antibodies  >200 publications with BMP4 and Brain
 Vascular Antibodies  >175 publications with BMP4 and Vascular
 Heart Antibodies  >143 publications with BMP4 and Heart
 Mouth Antibodies  >141 publications with BMP4 and Mouth
 Connective Tissue Antibodies  >139 publications with BMP4 and Connective Tissue
 Eye Antibodies  >127 publications with BMP4 and Eye
 Skin Antibodies  >98 publications with BMP4 and Skin
 Lung Antibodies  >96 publications with BMP4 and Lung
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