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BMP-2 recombinant protein :: Bone Morphogenetic protein-2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS553031 BMP-2 recombinant protein
Unit / Price
0.002 mg  /  $145 +1 FREE 8GB USB
0.01 mg  /  $220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bone Morphogenetic protein-2 (BMP-2), Recombinant Protein

 Also Known As   

Human Bone Morphogenetic protein-2 Recombinant

 Product Synonym Names    bmp2; bone morphogenetic protein; bmp-2
 Product Gene Name   

BMP-2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MVAGTRCLLA LLLPQVLLGG AAGLVPELGR RKFAAASSGR PSSQPSDEVL SEFELRLLSM FGLKQRPTPS RDAVVPPYML DLYRRHSGQP GSPAPDHRLE RAASRANTVR SFHHEESLEE LPETSGKTTR RFFFNLSSIP TEEFITSAEL QVFREQMQDA LGNNSSFHHR INIYEIIKPA TANSKFPVTR LLDTRLVNQN ASRWESFDVT PAVMRWTAQG HANHGFVVEV AHLEEKQGVS KRHVRISRSL HQDEHSWSQI RPLLVTFGHD GKGHPLHKRE KRQAKHKQRK RLKSSCKRHP LYVDFSDVGW NDWIVAPPGY HAFYCHGECP FPLADHLNST NHAIVQTLVN SVNSKIPKAC CVPTELSAIS MLYLDENEKV VLKNYQDMVV EGCGCR
 OMIM    112261
 3D Structure    ModBase 3D Structure for P12643
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 Host    E Coli
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 Purity/Purification    >95%, as determined by SDS-PAGE and HPLC
 Form/Format    Recombinant Human Bone Morphogenetic Protein-2 was lyophilized from a 0.2 um filtered solution in 20mM AcOH pH 6.5.
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 Domain    Transforming growh factor beta
 Host Note    Optimized DNA sequence encoding Human Bone Morphogenetic Protein-2 mature chain was expressed in Escherichia Coli.
 Endotoxin    Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
 Molecular Weight Note    Native human Bone Morphogenetic Protein-2 is generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 13 kDa.

Recombinant BMP-2 is a disulfide-linked homodimeric protein consisting of two 114 amino acid residue subunits. BMP2 migrates as an approximately 25 kDa protein under non-reducing conditions and as a 13 kDa protein under reducing conditions in SDS-PAGE.
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 Preparation and Storage    The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of BMP-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BMP-2 recombinant protein

   BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some of the proteins induce the synthesis of alkaline phosphatase and collagen in osteoblasts. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signaling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP-2 wild type binds to its cellular receptors via two distinct binding epitopes. The large epitope 1 is responsible for the high- affinity binding to the BMPR-IA receptor, the smaller epitope 2 provides the low-affinity binding to the receptor BMPR-II.
 Product Categories/Family for BMP-2 recombinant protein    Cytokines
NCBI/Uniprot data below describe general gene information for BMP-2. It may not necessarily be applicable to this product.
 NCBI GI #    4557369
 NCBI GeneID    650
 NCBI Accession #    NP_001191.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001200.2 [Other Products]
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 UniProt Primary Accession #    P12643 [Other Products]
 UniProt Related Accession #    P12643 [Other Products]
 Molecular Weight    44,702 Da
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 NCBI Official Full Name    bone morphogenetic protein 2 preproprotein
 UniProt Protein Name    Bone morphogenetic protein 2
 UniProt Synonym Protein Names   
Bone morphogenetic protein 2A
 UniProt Gene Name    BMP2 [Similar Products]
 UniProt Synonym Gene Names    BMP2A; BMP-2; BMP-2A [Similar Products]
 UniProt Entry Name    BMP2_HUMAN
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 NCBI Summary for BMP-2    The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BMP-2    Function: Induces cartilage and bone formation.

Subunit structure: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN

By similarity. Ref.4

Subcellular location: Secreted.

Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Pharmaceutical use: Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft fractures.

Sequence similarities: Belongs to the TGF-beta family.
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Product References and Citations for BMP-2 recombinant protein

   recombinant human bmp-2 enhances local bone formation in the lumbar spine of osteoporotic sheep .J Bone Joint Surg Br Proceedings, Sep 2009; 91-B: 436.
remodeling of chromatin structure within the promoter is important for bmp-2-induced fgfr3 expression .Nucleic Acids Res., Jul 2009; 37: 3897 - 3911.
bmp-2 is a cost-effective therapy in grade iii open tibia fractures – a health-economic assessment of the use bmp-2 in open tibia fractures for european health care systems .J Bone Joint Surg Br Proceedings, Mar 2009; 91-B: 155.
activation of amp kinase and inhibition of rho kinase induce the mineralization of osteoblastic mc3t3-e1 cells through endothelial nos and bmp-2 expression .Am J Physiol Endocrinol Metab, Jan 2009; 296: E139 - E146.
irbesartan attenuates ang ii-induced bmp-2 expression in human umbilical vein endothelial cells .Vascular Medicine, Aug 2008; 13: 239 - 245.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMP-2 recombinant proteinPathways associated with BMP-2 recombinant protein
 Reference Product  PubMed Publications
 TGFB1 recombinant protein  >191 publications with BMP-2 and TGFB1
 BMPR2 recombinant protein  >175 publications with BMP-2 and BMPR2
 BMPR1A recombinant protein  >150 publications with BMP-2 and BMPR1A
 BMPR1B recombinant protein  >46 publications with BMP-2 and BMPR1B
 MGP recombinant protein  >28 publications with BMP-2 and MGP
 COL2A1 recombinant protein  >25 publications with BMP-2 and COL2A1
 TGFB2 recombinant protein  >21 publications with BMP-2 and TGFB2
 ACVR1 recombinant protein  >17 publications with BMP-2 and ACVR1
 ASCL1 recombinant protein  >11 publications with BMP-2 and ASCL1
 NOG recombinant protein  >9 publications with BMP-2 and NOG
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
Diseases associated with BMP-2 recombinant proteinOrgans/Tissues associated with BMP-2 recombinant protein
 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >423 publications with BMP-2 and Bone Diseases
 Neoplasms Antibodies  >210 publications with BMP-2 and Neoplasms
 Osteoporosis Antibodies  >111 publications with BMP-2 and Osteoporosis
 Congenital Abnormalities Antibodies  >81 publications with BMP-2 and Congenital Abnormalities
 Inflammation Antibodies  >58 publications with BMP-2 and Inflammation
 Craniofacial Abnormalities Antibodies  >37 publications with BMP-2 and Craniofacial Abnormalities
 Lung Diseases Antibodies  >34 publications with BMP-2 and Lung Diseases
 Hypertension Antibodies  >33 publications with BMP-2 and Hypertension
 Leukemia Antibodies  >33 publications with BMP-2 and Leukemia
 Pain Antibodies  >31 publications with BMP-2 and Pain
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >3094 publications with BMP-2 and Bone
 Connective Tissue Antibodies  >477 publications with BMP-2 and Connective Tissue
 Embryonic Tissue Antibodies  >367 publications with BMP-2 and Embryonic Tissue
 Heart Antibodies  >134 publications with BMP-2 and Heart
 Brain Antibodies  >131 publications with BMP-2 and Brain
 Kidney Antibodies  >58 publications with BMP-2 and Kidney
 Lung Antibodies  >51 publications with BMP-2 and Lung
 Liver Antibodies  >47 publications with BMP-2 and Liver
 Eye Antibodies  >45 publications with BMP-2 and Eye
 Prostate Antibodies  >24 publications with BMP-2 and Prostate
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