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BMP3 recombinant protein :: Bone morphogenetic protein 3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS948539
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $675 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $825 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $910 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,020 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,040 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,065 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,510 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,545 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,630 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,025 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bone morphogenetic protein 3 (BMP3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Bone morphogenetic protein 3

 Product Synonym Names    Bone morphogenetic protein 3A; BMP-3A; Osteogenin
 Product Gene Name   

BMP3 recombinant protein

[Similar Products]
 Product Synonym Gene Name    BMP3A [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    363-472aa; Full Length
 Sequence    QWIEPRNCAR RYLKVDFADI GWSEWIISPK SFDAYYCSGA CQFPMPKSLK PSNHATIQSI VRAVGVVPGI PEPCCVPEKM SSLSILFFDE NKNVVLKVYP NMTVESCACR
 OMIM    112263
 3D Structure    ModBase 3D Structure for P12645
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of BMP3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BMP3 recombinant protein

   Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.
 Product Categories/Family for BMP3 recombinant protein    Developmental Biology
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 SDS-PAGE of BMP3 recombinant protein    BMP3 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for BMP3. It may not necessarily be applicable to this product.
 NCBI GI #    126507087
 NCBI GeneID    651
 NCBI Accession #    NP_001192.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001201.2 [Other Products]
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 UniProt Primary Accession #    P12645 [Other Products]
 UniProt Secondary Accession #    Q4VAS5 [Other Products]
 UniProt Related Accession #    P12645 [Other Products]
 Molecular Weight    16.6kD
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 NCBI Official Full Name    bone morphogenetic protein 3 preproprotein
 NCBI Official Synonym Full Names    bone morphogenetic protein 3
 NCBI Official Symbol    BMP3 [Similar Products]
 NCBI Official Synonym Symbols   
BMP-3A
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein 3
 UniProt Protein Name    Bone morphogenetic protein 3
 UniProt Synonym Protein Names   
Bone morphogenetic protein 3A; BMP-3A; Osteogenin
 Protein Family    Bone morphogenetic protein
 UniProt Gene Name    BMP3 [Similar Products]
 UniProt Synonym Gene Names    BMP3A; BMP-3; BMP-3A [Similar Products]
 UniProt Entry Name    BMP3_HUMAN
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 NCBI Summary for BMP3    BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein, also known as osteogenin, induces bone formation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BMP3    BMP3: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space

Molecular Function: cytokine activity; growth factor activity; receptor binding; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; cartilage development; cell development; cell-cell signaling; growth; osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development
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Product References and Citations for BMP3 recombinant protein

   Novel regulators of bone formation molecular clones and activities.Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A.Science 242:1528-1534(1988) Generation and annotation of the DNA sequences of human chromosomes 2 and 4.Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.Nature 434:724-731(2005) Bone morphogenetic protein-3 is a negative regulator of bone density.Daluiski A., Engstrand T., Bahamonde M.E., Gamer L.W., Agius E., Stevenson S.L., Cox K., Rosen V., Lyons K.M.Nat. Genet. 27:84-88(2001) BMP signaling components are expressed in human fracture callus.Kloen P., Di Paola M., Borens O., Richmond J., Perino G., Helfet D.L., Goumans M.J.Bone 33:362-371(2003) Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery.Kang Q., Sun M.H., Cheng H., Peng Y., Montag A.G., Deyrup A.T., Jiang W., Luu H.H., Luo J., Szatkowski J.P., Vanichakarn P., Park J.Y., Li Y., Haydon R.C., He T.-C.Gene Ther. 11:1312-1320(2004) Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage.Chen A.L., Fang C., Liu C., Leslie M.P., Chang E., Di Cesare P.E.J. Orthop. Res. 22:1188-1192(2004) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors.Allendorph G.P., Isaacs M.J., Kawakami Y., Izpisua Belmonte J.C., Choe S.Biochemistry 46:12238-12247(2007)
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 Research Articles on BMP3    1. Methylation level in stool decreases dramatically following colorectal cancer resection
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMP3 recombinant proteinPathways associated with BMP3 recombinant protein
 Reference Product  PubMed Publications
 BMPR2 recombinant protein  >8 publications with BMP3 and BMPR2
 BMP1 recombinant protein  >6 publications with BMP3 and BMP1
 BMPR1B recombinant protein  >4 publications with BMP3 and BMPR1B
 ACVR2A recombinant protein  >2 publications with BMP3 and ACVR2A
 AMBN recombinant protein  >1 publications with BMP3 and AMBN
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
Diseases associated with BMP3 recombinant proteinOrgans/Tissues associated with BMP3 recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with BMP3 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >5 publications with BMP3 and Cell Transformation, Neoplastic
 Fibrosis Antibodies  >5 publications with BMP3 and Fibrosis
 Chromosome Aberrations Antibodies  >4 publications with BMP3 and Chromosome Aberrations
 Inflammation Antibodies  >4 publications with BMP3 and Inflammation
 Hyperplasia Antibodies  >3 publications with BMP3 and Hyperplasia
 Lung Neoplasms Antibodies  >3 publications with BMP3 and Lung Neoplasms
 Necrosis Antibodies  >3 publications with BMP3 and Necrosis
 Lung Diseases Antibodies  >2 publications with BMP3 and Lung Diseases
 Prostatic Diseases Antibodies  >2 publications with BMP3 and Prostatic Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >18 publications with BMP3 and Muscle
 Embryonic Tissue Antibodies  >15 publications with BMP3 and Embryonic Tissue
 Bone Marrow Antibodies  >14 publications with BMP3 and Bone Marrow
 Blood Antibodies  >13 publications with BMP3 and Blood
 Lung Antibodies  >8 publications with BMP3 and Lung
 Eye Antibodies  >6 publications with BMP3 and Eye
 Intestine Antibodies  >5 publications with BMP3 and Intestine
 Prostate Antibodies  >3 publications with BMP3 and Prostate
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