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BMP7 recombinant protein :: Bone morphogenetic protein 7 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1265438
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bone morphogenetic protein 7 (BMP7), Recombinant Protein

 Also Known As   

Recombinant Human Bone morphogenetic protein 7

 Product Synonym Names    Osteogenic protein 1; OP-1; INN: Eptotermin alfa
 Product Gene Name   

BMP7 recombinant protein

[Similar Products]
 Product Synonym Gene Name    OP1; BMP-7 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    293-431aa; Full Length
 Sequence    STGSKQRSQN RSKTPKNQEA LRMANVAENS SSDQRQACKK HELYVSFRDL GWQDWIIAPE GYAAYYCEGE CAFPLNSYMN ATNHAIVQTL VHFINPETVP KPCCAPTQLN AISVLYFDDS SNVILKKYRN MVVRACGCH
 OMIM    112267
 3D Structure    ModBase 3D Structure for P18075
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of BMP7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BMP7 recombinant protein

   Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
 Product Categories/Family for BMP7 recombinant protein    Developmental Biology
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 SDS-PAGE of BMP7 recombinant protein    BMP7 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for BMP7. It may not necessarily be applicable to this product.
 NCBI GI #    4502427
 NCBI GeneID    655
 NCBI Accession #    NP_001710.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001719.2 [Other Products]
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 UniProt Primary Accession #    P18075 [Other Products]
 UniProt Secondary Accession #    Q9H512; Q9NTQ7 [Other Products]
 UniProt Related Accession #    P18075 [Other Products]
 Molecular Weight    43.1kD
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 NCBI Official Full Name    bone morphogenetic protein 7 preproprotein
 NCBI Official Synonym Full Names    bone morphogenetic protein 7
 NCBI Official Symbol    BMP7 [Similar Products]
 NCBI Official Synonym Symbols   
OP-1
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein 7
 UniProt Protein Name    Bone morphogenetic protein 7
 UniProt Synonym Protein Names   
Osteogenic protein 1; OP-1; INN: Eptotermin alfa
 Protein Family    Bone morphogenetic protein
 UniProt Gene Name    BMP7 [Similar Products]
 UniProt Synonym Gene Names    OP1; BMP-7; OP-1 [Similar Products]
 UniProt Entry Name    BMP7_HUMAN
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 NCBI Summary for BMP7    This gene encodes a member of the transforming growth factor-beta (TGF-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate each subunit of the mature homodimer, which plays a role in bone, kidney and brown adipose tissue development. This protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Nov 2015]
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 UniProt Comments for BMP7    BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: extracellular matrix; extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; heparin binding; protein binding; transforming growth factor beta receptor binding

Biological Process: axon guidance; BMP signaling pathway; branching morphogenesis of a tube; cartilage development; dendrite development; embryonic camera-type eye morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; epithelial cell differentiation; epithelial to mesenchymal transition; extracellular matrix organization and biogenesis; growth; inhibition of NF-kappaB transcription factor; mesenchymal cell differentiation; mesoderm formation; mesonephros development; metanephros development; negative regulation of cell cycle; negative regulation of MAP kinase activity; negative regulation of mitosis; negative regulation of neuron differentiation; negative regulation of NF-kappaB import into nucleus; negative regulation of Notch signaling pathway; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; neurite morphogenesis; odontogenesis of dentine-containing teeth; ossification; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of heterotypic cell-cell adhesion; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; response to estradiol stimulus; response to peptide hormone stimulus; response to vitamin D; skeletal development; steroid hormone mediated signaling; ureteric bud development
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Product References and Citations for BMP7 recombinant protein

   OP-1 cDNA encodes an osteogenic protein in the TGF-beta family.Oezkaynak E., Rueger D.C., Drier E.A., Corbett C., Ridge R.J., Sampath T.K., Oppermann H.EMBO J. 9:2085-2093(1990) Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) The DNA sequence and comparative analysis of human chromosome 20.Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.Nature 414:865-871(2001) Expression and characterization of a human BMP-7 variant with improved biochemical properties.Swencki-Underwood B., Mills J.K., Vennarini J., Boakye K., Luo J., Pomerantz S., Cunningham M.R., Farrell F.X., Naso M.F., Amegadzie B.Protein Expr. Purif. 57:312-319(2008) USAG-1 a bone morphogenetic protein antagonist abundantly expressed in the kidney.Yanagita M., Oka M., Watabe T., Iguchi H., Niida A., Takahashi S., Akiyama T., Miyazono K., Yanagisawa M., Sakurai T.Biochem. Biophys. Res. Commun. 316:490-500(2004) Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies.Wyatt A.W., Osborne R.J., Stewart H., Ragge N.K.Hum. Mutat. 31:781-787(2010) Three-dimensional structure of recombinant human osteogenic protein 1 structural paradigm for the transforming growth factor beta superfamily.Griffith D.L., Keck P.C., Sampath T.K., Rueger D.C., Carlson W.D.Proc. Natl. Acad. Sci. U.S.A. 93:878-883(1996)
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 Research Articles on BMP7    1. OP-1 levels detected by a polyclonal antibody were found to be much higher than the reference range and correlated positively with the severity of osteoarthritis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMP7 recombinant proteinPathways associated with BMP7 recombinant protein
 Reference Product  PubMed Publications
 BMPR2 recombinant protein  >120 publications with BMP7 and BMPR2
 SMAD5 recombinant protein  >43 publications with BMP7 and SMAD5
 BMPR1A recombinant protein  >40 publications with BMP7 and BMPR1A
 BMPR1B recombinant protein  >27 publications with BMP7 and BMPR1B
 ACVR1 recombinant protein  >26 publications with BMP7 and ACVR1
 SMAD6 recombinant protein  >25 publications with BMP7 and SMAD6
 ACVR2A recombinant protein  >6 publications with BMP7 and ACVR2A
 SOSTDC1 recombinant protein  >4 publications with BMP7 and SOSTDC1
 NOG recombinant protein  >4 publications with BMP7 and NOG
 FST recombinant protein  >3 publications with BMP7 and FST
 Products by Pathway  Pathway Diagram
 ALK2 Signaling Events Pathway antibodies  ALK2 Signaling Events Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
Diseases associated with BMP7 recombinant proteinOrgans/Tissues associated with BMP7 recombinant protein
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >121 publications with BMP7 and Fibrosis
 Disease Models, Animal Antibodies  >110 publications with BMP7 and Disease Models, Animal
 Kidney Diseases Antibodies  >106 publications with BMP7 and Kidney Diseases
 Inflammation Antibodies  >61 publications with BMP7 and Inflammation
 Cardiovascular Diseases Antibodies  >57 publications with BMP7 and Cardiovascular Diseases
 Necrosis Antibodies  >38 publications with BMP7 and Necrosis
 Bone Resorption Antibodies  >37 publications with BMP7 and Bone Resorption
 Renal Insufficiency Antibodies  >36 publications with BMP7 and Renal Insufficiency
 Hypertension Antibodies  >36 publications with BMP7 and Hypertension
 Prostatic Neoplasms Antibodies  >28 publications with BMP7 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1454 publications with BMP7 and Bone
 Kidney Antibodies  >223 publications with BMP7 and Kidney
 Connective Tissue Antibodies  >170 publications with BMP7 and Connective Tissue
 Muscle Antibodies  >123 publications with BMP7 and Muscle
 Brain Antibodies  >118 publications with BMP7 and Brain
 Mouth Antibodies  >94 publications with BMP7 and Mouth
 Eye Antibodies  >75 publications with BMP7 and Eye
 Heart Antibodies  >44 publications with BMP7 and Heart
 Lung Antibodies  >44 publications with BMP7 and Lung
 Prostate Antibodies  >39 publications with BMP7 and Prostate
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