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BXA1 recombinant protein :: Botulinum neurotoxin type A Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS9420883 BXA1 recombinant protein
Unit / Price
0.01 mg  /  $265 +1 FREE 8GB USB
0.05 mg  /  $350 +1 FREE 8GB USB
0.1 mg  /  $560 +1 FREE 8GB USB
0.2 mg  /  $880 +1 FREE 8GB USB
0.5 mg  /  $1,145 +1 FREE 8GB USB
1 mg  /  $1,795 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Botulinum neurotoxin type A (BXA1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Clostridium botulinum Botulinum neurotoxin type A

 Product Synonym Names    Bontoxilysin-A; BOTOX
 Product Gene Name   

BXA1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    Full Length, 1-436aa
 3D Structure    ModBase 3D Structure for P10845
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 Host    E Coli
 Species Reactivity    CLOBO
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    20mM Tris-HCl based buffer, pH8.0
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 Tag Info    His-SUMO-tag
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
 Other Notes    Small volumes of BXA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BXA1 recombinant protein

   Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic mbrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure.
NCBI/Uniprot data below describe general gene information for BXA1. It may not necessarily be applicable to this product.
 NCBI GI #    489451277
 NCBI GeneID   
 NCBI Accession #    WP_003356619.1 [Other Products]
 NCBI GenBank Nucleotide #    WP_003356619.1 [Other Products]
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 UniProt Primary Accession #    P10845 [Other Products]
 UniProt Secondary Accession #    P01561; P18639 [Other Products]
 Molecular Weight    65.94kD
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 NCBI Official Full Name    peptidase M27
 UniProt Protein Name    Botulinum neurotoxin type A
 UniProt Synonym Protein Names   
Bontoxilysin-A; BOTOX
 Protein Family    Botulinum neurotoxin
 UniProt Gene Name    botA [Similar Products]
 UniProt Synonym Gene Names    atx; bna; BoNT/A; BOTOX [Similar Products]
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 UniProt Comments for BXA1    Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BXA1 recombinant protein
 Reference Product  PubMed Publications
 ntnH recombinant protein  >2 publications with BXA1 and ntnH
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