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BDNF recombinant protein :: Brain-Derived Neurotrophic Factor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142084 BDNF recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,585 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Brain-Derived Neurotrophic Factor (BDNF), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Brain-Derived Neurotrophic Factor

 Product Synonym Names    BDNF Human; Brain-Derived Neurotrophic Factor Human Recombinant; Brain-Derived Neurotrophic Factor; BDNF; MGC34632
 Product Gene Name   

BDNF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
 OMIM    113505
 3D Structure    ModBase 3D Structure for P23560
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 Host    E Coli
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 Purity/Purification    BDNF is greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The protein was lyophilized WITHOUT ANY ADDITIVES.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized BDNF in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Protein Content    BDNF quantitation was carried out by two independent methods:1. UV spectroscopy at 280 nm using the absorbency value of 1.6 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of Brain-derived Neurotrophic Factor as a Reference Standard.
 Biological Activity    The ED50, calculated by the dose-dependent induction of ACHE (acetylcholine esterase) in rat basal forebrain primary septal culture is 50 ng/ml corresponding to a Specific Activity of 20,000IU/mg.
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 Preparation and Storage    Lyophilized BDNF although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution BDNF should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of BDNF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BDNF recombinant protein

   Description: Brain-Derived Neurotrophic Factor Human Recombinant produced in E Coli is a homodimer, non-glycosylated, polypeptide chain containing 2 x 119 amino acids and having a total molecular mass of 26,984 Dalton. BDNF Human Recombinant is purified by proprietary chromatographic techniques.

Introduction: BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. BDNF is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the cns. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (ltp), long-term depression (ltd), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
 Product Categories/Family for BDNF recombinant protein    CYTOKINES AND GROWTH FACTORS; Neurotrophins
NCBI/Uniprot data below describe general gene information for BDNF. It may not necessarily be applicable to this product.
 NCBI GI #    219842288
 NCBI GeneID    627
 NCBI Accession #    NP_001137277.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001143805.1 [Other Products]
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 UniProt Primary Accession #    P23560 [Other Products]
 UniProt Secondary Accession #    Q598Q1; Q6DN19; Q6YNR2; Q6YNR3; Q9BYY7; Q9UC24; A7LA85; A7LA92; D3DQZ2 [Other Products]
 UniProt Related Accession #    P23560 [Other Products]
 Molecular Weight    31,116 Da
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 NCBI Official Full Name    brain-derived neurotrophic factor isoform a preproprotein
 NCBI Official Synonym Full Names    brain-derived neurotrophic factor
 NCBI Official Symbol    BDNF [Similar Products]
 NCBI Official Synonym Symbols   
ANON2; BULN2
[Similar Products]
 NCBI Protein Information    brain-derived neurotrophic factor; abrineurin; neurotrophin
 UniProt Protein Name    Brain-derived neurotrophic factor
 UniProt Synonym Protein Names   
Abrineurin
 Protein Family    Brain-derived neurotrophic factor
 UniProt Gene Name    BDNF [Similar Products]
 UniProt Synonym Gene Names    BDNF [Similar Products]
 UniProt Entry Name    BDNF_HUMAN
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 NCBI Summary for BDNF    The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
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 UniProt Comments for BDNF    BDNF: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. Belongs to the NGF-beta family. 5 isoforms of the human protein are produced by alternative promoter.

Protein type: Cell development/differentiation; Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: extracellular space; mitochondrial crista; synaptic vesicle; perinuclear region of cytoplasm; cytoplasmic membrane-bound vesicle; dendrite; cytoplasm; extracellular region; terminal button; perikaryon

Molecular Function: growth factor activity; neurotrophin TRKB receptor binding

Biological Process: circadian rhythm; axon guidance; mechanoreceptor differentiation; behavioral fear response; mitochondrial electron transport, NADH to ubiquinone; axon extension; regulation of neuron differentiation; response to hormone stimulus; positive regulation of long-term neuronal synaptic plasticity; response to vitamin A; negative regulation of neuroblast proliferation; ureteric bud development; dendrite development; regulation of retinal cell programmed cell death; feeding behavior; negative regulation of neuron apoptosis; response to electrical stimulus; negative regulation of synaptic transmission, GABAergic; inner ear development; response to food; nervous system development; chronic inflammatory response; response to light intensity; neuron recognition; learning; regulation of short-term neuronal synaptic plasticity; regulation of axon extension; negative regulation of striated muscle development; positive regulation of peptidyl-serine phosphorylation; positive regulation of synaptogenesis; response to hyperoxia; axon target recognition; glutamate secretion; response to hypoxia; response to fluoxetine; nerve development; response to activity; positive regulation of neuron differentiation; regulation of excitatory postsynaptic membrane potential; gamma-aminobutyric acid signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis

Disease: Obsessive-compulsive Disorder; Bulimia Nervosa, Susceptibility To, 1; Bulimia Nervosa, Susceptibility To, 2; Central Hypoventilation Syndrome, Congenital
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 Research Articles on BDNF    1. the BDNF Val66Met polymorphism seems to modulate the electrical activity of the brain, predicting interindividual variation of sleep EEG parameters
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with BDNF recombinant proteinDiseases associated with BDNF recombinant protein
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3762 publications with BDNF and Nervous System Diseases
 Brain Injuries Antibodies  >861 publications with BDNF and Brain Injuries
 Depressive Disorder Antibodies  >712 publications with BDNF and Depressive Disorder
 Schizophrenia Antibodies  >600 publications with BDNF and Schizophrenia
 Cognition Disorders Antibodies  >589 publications with BDNF and Cognition Disorders
 Body Weight Antibodies  >585 publications with BDNF and Body Weight
 Brain Ischemia Antibodies  >575 publications with BDNF and Brain Ischemia
 Inflammation Antibodies  >574 publications with BDNF and Inflammation
 Memory Disorders Antibodies  >560 publications with BDNF and Memory Disorders
 Nerve Degeneration Antibodies  >552 publications with BDNF and Nerve Degeneration
Organs/Tissues associated with BDNF recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14503 publications with BDNF and Brain
 Eye Antibodies  >644 publications with BDNF and Eye
 Embryonic Tissue Antibodies  >567 publications with BDNF and Embryonic Tissue
 Heart Antibodies  >183 publications with BDNF and Heart
 Skin Antibodies  >151 publications with BDNF and Skin
 Connective Tissue Antibodies  >119 publications with BDNF and Connective Tissue
 Lung Antibodies  >118 publications with BDNF and Lung
 Liver Antibodies  >102 publications with BDNF and Liver
 Thyroid Antibodies  >84 publications with BDNF and Thyroid
 Adrenal Gland Antibodies  >70 publications with BDNF and Adrenal Gland
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