NP_001009858.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
377,345 Da
NCBI Official Full Name
breast cancer type 2 susceptibility protein homolog
NCBI Protein Information
breast cancer type 2 susceptibility protein homolog
UniProt Protein Name
Breast cancer type 2 susceptibility protein homolog
UniProt Synonym Protein Names
Fanconi anemia group D1 protein homolog
UniProt Synonym Gene Names
UniProt Comments for BRCA2
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination ().
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Pathways associated with BRCA2 recombinant protein
Diseases associated with BRCA2 recombinant protein
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