NP_116738.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
C-C motif chemokine 14 isoform 2
NCBI Official Synonym Full Names
C-C motif chemokine ligand 14
NCBI Official Synonym Symbols
CC-1; CC-3; CKB1; MCIF; NCC2; SY14; HCC-1; HCC-3; NCC-2; SCYL2; SCYA14; HCC-1(1-74); HCC-1/HCC-3 [Similar Products]
NCBI Protein Information
C-C motif chemokine 14
UniProt Protein Name
C-C motif chemokine 14
UniProt Synonym Protein Names
Chemokine CC-1/CC-3; HCC-1/HCC-3
UniProt Synonym Gene Names
NCBI Summary for CCL14
This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]
UniProt Comments for CCL14
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
Research Articles on CCL14
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Products associated with CCL14 recombinant protein
Pathways associated with CCL14 recombinant protein
Diseases associated with CCL14 recombinant protein
Organs/Tissues associated with CCL14 recombinant protein
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