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Ccl19 recombinant protein :: C-C motif chemokine 19 protein (Ccl19) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS969250
SDS-PAGE
Unit / Price
0.005 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.25 mg  /  $725 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C-C motif chemokine 19 protein (Ccl19), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse C-C motif chemokine 19 protein (Ccl19) (Active)

 Product Synonym Names    Epstein-Barr virus-induced molecule 1 ligand chemokine; ELC; Small-inducible cytokine A19
 Product Gene Name   

Ccl19 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Elc; Scya19 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    26-108aa, Full Length of Mature Protein
 Sequence    GANDAEDCCL SVTQRPIPGN IVKAFRYLLN EDGCRVPAVV FTTLRGYQLC APPDQPWVDR IIRRLKKSSA KNKGNSTRRS PVS
 3D Structure    ModBase 3D Structure for O70460
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 Host    E Coli
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 Purity/Purification    >=97% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
 Biological Activity    Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human mature dendritic cells is in a concentration range of 10-100 ng/ml.
 Storage Buffer    0.2 um filtered PBS, pH 7.4,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Ccl19 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Ccl19 recombinant protein

   Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
 Product Categories/Family for Ccl19 recombinant protein    Biological Active Protein; Immunology; Chemokine
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 SDS-PAGE of Ccl19 recombinant protein    Ccl19 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Ccl19. It may not necessarily be applicable to this product.
 NCBI GI #    6755422
 NCBI GeneID    24047
 NCBI Accession #    NP_036018.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_011888.2 [Other Products]
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 UniProt Primary Accession #    O70460 [Other Products]
 UniProt Related Accession #    O70460 [Other Products]
 Molecular Weight    9.2 kDa
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 NCBI Official Full Name    C-C motif chemokine 19
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 19
 NCBI Official Symbol    Ccl19 [Similar Products]
 NCBI Official Synonym Symbols   
ELC; CKb11; MIP3B; Scya19; exodus-3
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 19
 UniProt Protein Name    C-C motif chemokine 19
 UniProt Synonym Protein Names   
Epstein-Barr virus-induced molecule 1 ligand chemokine; EBI1 ligand chemokine; ELC; Small-inducible cytokine A19
 Protein Family    C-C motif chemokine
 UniProt Gene Name    Ccl19 [Similar Products]
 UniProt Synonym Gene Names    Elc; Scya19; EBI1 ligand chemokine; ELC [Similar Products]
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 UniProt Comments for Ccl19    CCL19: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4|4 A5

Cellular Component: external side of plasma membrane; extracellular space

Molecular Function: CCR chemokine receptor binding; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding; chemokine activity; chemokine receptor binding

Biological Process: activation of JNK activity; cell maturation; dendritic cell chemotaxis; establishment of T cell polarity; formation of immunological synapse; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; myeloid dendritic cell chemotaxis; neutrophil chemotaxis; positive regulation of chemotaxis; positive regulation of dendritic cell antigen processing and presentation; positive regulation of endocytosis; positive regulation of GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-12 production; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling cascade; positive regulation of receptor-mediated endocytosis; positive regulation of T cell proliferation; positive regulation of T-helper 1 cell differentiation; positive regulation of tumor necrosis factor production; release of sequestered calcium ion into cytosol; T cell costimulation
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 Research Articles on Ccl19    1. The beneficial effects of epicatechin in ameriorating diet-induced obesity and insulin resistance could be mediated, at least in part, by marked suppression of CCL19 expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Ccl19 recombinant proteinPathways associated with Ccl19 recombinant protein
 Reference Product  PubMed Publications
 Ccr7 recombinant protein  >480 publications with Ccl19 and Ccr7
 Cxcl12 recombinant protein  >143 publications with Ccl19 and Cxcl12
 Cxcl13 recombinant protein  >105 publications with Ccl19 and Cxcl13
 Cxcr3 recombinant protein  >27 publications with Ccl19 and Cxcr3
 Ccr1 recombinant protein  >25 publications with Ccl19 and Ccr1
 Ccrl1 recombinant protein  >12 publications with Ccl19 and Ccrl1
 Ccr9 recombinant protein  >10 publications with Ccl19 and Ccr9
 Cxcr2 recombinant protein  >5 publications with Ccl19 and Cxcr2
 S1pr1 recombinant protein  >3 publications with Ccl19 and S1pr1
 Ccl6 recombinant protein  >1 publications with Ccl19 and Ccl6
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with Ccl19 recombinant proteinOrgans/Tissues associated with Ccl19 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >172 publications with Ccl19 and Inflammation
 Necrosis Antibodies  >70 publications with Ccl19 and Necrosis
 Respiratory Tract Diseases Antibodies  >53 publications with Ccl19 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >48 publications with Ccl19 and Lung Diseases
 Vascular Diseases Antibodies  >38 publications with Ccl19 and Vascular Diseases
 Cardiovascular Diseases Antibodies  >37 publications with Ccl19 and Cardiovascular Diseases
 Hypersensitivity Antibodies  >29 publications with Ccl19 and Hypersensitivity
 Atherosclerosis Antibodies  >24 publications with Ccl19 and Atherosclerosis
 Lung Neoplasms Antibodies  >16 publications with Ccl19 and Lung Neoplasms
 Liver Diseases Antibodies  >16 publications with Ccl19 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >296 publications with Ccl19 and Lymph Node
 Spleen Antibodies  >78 publications with Ccl19 and Spleen
 Thymus Antibodies  >41 publications with Ccl19 and Thymus
 Embryonic Tissue Antibodies  >15 publications with Ccl19 and Embryonic Tissue
 Salivary Gland Antibodies  >7 publications with Ccl19 and Salivary Gland
 Mammary Gland Antibodies  >1 publications with Ccl19 and Mammary Gland
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