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CXCR1 recombinant protein :: C-X-C chemokine receptor type 1 (CXCR1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS948697
SDS-PAGE
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 Product Name   

C-X-C chemokine receptor type 1 (CXCR1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human C-X-C chemokine receptor type 1 (CXCR1)

 Product Synonym Names    Recombinant C-X-C chemokine receptor type 1 (CXCR1); C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; CDw128a High affinity interleukin-8 receptor A; IL-8R A IL-8 receptor type 1 CD_antigen= CD181
 Product Gene Name   

CXCR1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    CXCR1; CMKAR1, IL8RA [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-39
 Sequence    MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNK
 Chromosome Location    Chromosome: 2; NC_000002.11 (219027568..219031716, complement). Location: 2q35
 OMIM    146929
 3D Structure    ModBase 3D Structure for P25024
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90%(SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C. Notes ? Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CXCR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CXCR1 recombinant protein

   Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
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 SDS-PAGE of CXCR1 recombinant protein    CXCR1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for CXCR1. It may not necessarily be applicable to this product.
 NCBI GI #    4504681
 NCBI GeneID    3577
 NCBI Accession #    NP_000625.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000634.2 [Other Products]
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 UniProt Primary Accession #    P25024 [Other Products]
 UniProt Secondary Accession #    Q2YEF8; Q2YEG4; Q2YEG5; Q2YEG7; Q2YEG8; Q53R18; Q6IN95; Q8N6T6; Q9P2T8; Q9P2T9; B2R6Q3 [Other Products]
 UniProt Related Accession #    P25024 [Other Products]
 Molecular Weight    6kD [Similar Products]
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 NCBI Official Full Name    C-X-C chemokine receptor type 1
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) receptor 1
 NCBI Official Symbol    CXCR1 [Similar Products]
 NCBI Official Synonym Symbols   
C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1
[Similar Products]
 NCBI Protein Information    C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; IL-8R A; IL-8 receptor type 1; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A; high affinity interleukin-8 receptor A
 UniProt Protein Name    C-X-C chemokine receptor type 1
 UniProt Synonym Protein Names   
CDw128a; High affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1
 Protein Family    C-X-C chemokine receptor
 UniProt Gene Name    CXCR1 [Similar Products]
 UniProt Synonym Gene Names    CMKAR1; IL8RA; CXC-R1; CXCR-1; IL-8R A [Similar Products]
 UniProt Entry Name    CXCR1_HUMAN
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 NCBI Summary for CXCR1    The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CXCR1    IL8RA: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; Receptor, cytokine; GPCR, family 1

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; interleukin-8 receptor activity; chemokine receptor activity; interleukin-8 binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; receptor internalization; dendritic cell chemotaxis; chemotaxis; inflammatory response

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on CXCR1    1. The proportions of IL-18Ralpha-expressing T lymphocytes and CD8(+) T lymphocytes were significantly higher in stable COPD patients than in nonsmokers and current smokers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CXCR1 recombinant proteinPathways associated with CXCR1 recombinant protein
 Reference Product  PubMed Publications
 CXCR2 recombinant protein  >431 publications with CXCR1 and CXCR2
 CXCL1 recombinant protein  >83 publications with CXCR1 and CXCL1
 IL8 recombinant protein  >34 publications with CXCR1 and IL8
 CXCL5 recombinant protein  >23 publications with CXCR1 and CXCL5
 CXCL6 recombinant protein  >20 publications with CXCR1 and CXCL6
 CXCL2 recombinant protein  >18 publications with CXCR1 and CXCL2
 PPBP recombinant protein  >5 publications with CXCR1 and PPBP
 CXCL3 recombinant protein  >5 publications with CXCR1 and CXCL3
 GNAI2 recombinant protein  >2 publications with CXCR1 and GNAI2
 ADRA1A recombinant protein  >1 publications with CXCR1 and ADRA1A
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
Diseases associated with CXCR1 recombinant proteinOrgans/Tissues associated with CXCR1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >194 publications with CXCR1 and Inflammation
 Neoplasms Antibodies  >108 publications with CXCR1 and Neoplasms
 Lung Diseases Antibodies  >69 publications with CXCR1 and Lung Diseases
 Necrosis Antibodies  >62 publications with CXCR1 and Necrosis
 Skin Diseases Antibodies  >36 publications with CXCR1 and Skin Diseases
 Disease Models, Animal Antibodies  >30 publications with CXCR1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >26 publications with CXCR1 and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >26 publications with CXCR1 and Gastrointestinal Diseases
 Sepsis Antibodies  >20 publications with CXCR1 and Sepsis
 Liver Diseases Antibodies  >16 publications with CXCR1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >356 publications with CXCR1 and Blood
 Lung Antibodies  >83 publications with CXCR1 and Lung
 Bone Antibodies  >32 publications with CXCR1 and Bone
 Brain Antibodies  >29 publications with CXCR1 and Brain
 Bone Marrow Antibodies  >24 publications with CXCR1 and Bone Marrow
 Liver Antibodies  >22 publications with CXCR1 and Liver
 Intestine Antibodies  >17 publications with CXCR1 and Intestine
 Heart Antibodies  >14 publications with CXCR1 and Heart
 Spleen Antibodies  >9 publications with CXCR1 and Spleen
 Thymus Antibodies  >5 publications with CXCR1 and Thymus
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