NP_998938.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
39,945 Da
NCBI Official Full Name
C-X-C chemokine receptor type 4
NCBI Protein Information
C-X-C chemokine receptor type 4
UniProt Protein Name
C-X-C chemokine receptor type 4
UniProt Synonym Protein Names
CD_antigen: CD184
UniProt Synonym Gene Names
UniProt Entry Name
CXCR4_PIG
UniProt Comments for CXCR4
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes ().
Research Articles on CXCR4
Precautions
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Disclaimer
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Products associated with CXCR4 recombinant protein
Pathways associated with CXCR4 recombinant protein
Diseases associated with CXCR4 recombinant protein
Organs/Tissues associated with CXCR4 recombinant protein
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