O08565.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
39,334 Da
NCBI Official Full Name
C-X-C chemokine receptor type 4
NCBI Official Synonym Full Names
C-X-C motif chemokine receptor 4
NCBI Protein Information
C-X-C chemokine receptor type 4
UniProt Protein Name
C-X-C chemokine receptor type 4
UniProt Synonym Protein Names
Fusin; Leukocyte-derived seven transmembrane domain receptor; LESTR; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD_antigen: CD184
UniProt Synonym Gene Names
UniProt Entry Name
CXCR4_RAT
NCBI Summary for Cxcr4
G protein-coupled receptor for the chemokine stromal cell-derived factor-1; may have a role in brain development [RGD, Feb 2006]
UniProt Comments for Cxcr4
CXCR4: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Monomer. Can form dimers. Interacts with CD164. Interacts with HIV-1 surface protein gp120 and Tat. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with human cytomegalovirus/HHV- 5 protein UL78. Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1
Cellular Component: cell junction; cell surface; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; early endosome; endosome; external side of plasma membrane; growth cone; integral to membrane; intercellular junction; late endosome; leading edge; lysosome; plasma membrane
Molecular Function: actin binding; C-C chemokine receptor activity; C-X-C chemokine receptor activity; cytokine binding; drug binding; myosin light chain binding; ubiquitin binding; ubiquitin protein ligase binding
Biological Process: ameboidal cell migration; brain development; calcium-mediated signaling; cardiac muscle contraction; cell migration; chemotaxis; epithelial cell development; G-protein coupled receptor protein signaling pathway; germ cell development; germ cell migration; motor axon guidance; myelin maintenance; neuron migration; neuron recognition; patterning of blood vessels; positive regulation of oligodendrocyte differentiation; positive regulation of protein amino acid phosphorylation; regulation of calcium ion transport; regulation of cell migration; regulation of chemotaxis; regulation of programmed cell death; response to hypoxia; T cell proliferation; telencephalon cell migration
Research Articles on Cxcr4
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Products associated with Cxcr4 recombinant protein
Pathways associated with Cxcr4 recombinant protein
Organs/Tissues associated with Cxcr4 recombinant protein
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