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CXCR4 recombinant protein :: C-X-C chemokine receptor type 4 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950362
SDS-Page
Unit / Price
0.05 mg (Baculovirus)  /  $950 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,170 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,400 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,860 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,860 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,760 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C-X-C chemokine receptor type 4 (CXCR4), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human C-X-C chemokine receptor type 4

 Product Synonym Names    FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD184
 Product Gene Name   

CXCR4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS950362 COA    COA PDF
 Sequence Positions    1-352
 Sequence    MEGISIYTSD NYTEEMGSGD YDSMKEPCFR EENANFNKIF LPTIYSIIFL TGIVGNGLVI LVMGYQKKLR SMTDKYRLHL SVADLLFVIT LPFWAVDAVA NWYFGNFLCK AVHVIYTVNL YSSVLILAFI SLDRYLAIVH ATNSQRPRKL LAEKVVYVGV WIPALLLTIP DFIFANVSEA DDRYICDRFY PNDLWVVVFQ FQHIMVGLIL PGIVILSCYC IIISKLSHSK GHQKRKALKT TVILILAFFA CWLPYYIGIS IDSFILLEII KQGCEFENTV HKWISITEAL AFFHCCLNPI LYAFLGAKFK TSAQHALTSV SRGSSLKILS KGKRGGHSSV STESESSSFH SS
 OMIM    162643
 3D Structure    ModBase 3D Structure for P61073
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CXCR4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CXCR4 recombinant protein

   Receptor for the C-X-C chokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hatopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes
 Product Categories/Family for CXCR4 recombinant protein    Immunology
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 SDS-Page of CXCR4 recombinant protein    CXCR4 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for CXCR4. It may not necessarily be applicable to this product.
 NCBI GI #    56790927
 NCBI GeneID    7852
 NCBI Accession #    NP_001008540.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001008540.1 [Other Products]
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 UniProt Primary Accession #    P61073 [Other Products]
 UniProt Secondary Accession #    O60835; P30991; P56438; Q53S69; Q9BXA0; Q9UKN2; B2R5N0 [Other Products]
 UniProt Related Accession #    P61073 [Other Products]
 Molecular Weight    44.2kD
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 NCBI Official Full Name    C-X-C chemokine receptor type 4 isoform a
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) receptor 4
 NCBI Official Symbol    CXCR4 [Similar Products]
 NCBI Official Synonym Symbols   
FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; D2S201E
[Similar Products]
 NCBI Protein Information    C-X-C chemokine receptor type 4
 UniProt Protein Name    C-X-C chemokine receptor type 4
 UniProt Synonym Protein Names   
FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD_antigen: CD184
 Protein Family    C-X-C chemokine receptor
 UniProt Gene Name    CXCR4 [Similar Products]
 UniProt Synonym Gene Names    CXC-R4; CXCR-4; LESTR; LAP-3; LPS-associated protein 3; SDF-1 receptor [Similar Products]
 UniProt Entry Name    CXCR4_HUMAN
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 NCBI Summary for CXCR4    This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CXCR4    Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
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Product References and Citations for CXCR4 recombinant protein

   Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor lack of NPY binding and activation.Herzog H., Hort Y.J., Shine J., Selbie L.A.DNA Cell Biol. 12:465-471(1993)
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 Research Articles on CXCR4    1. findings highlight a potential prognostic value of platelet expression CXCR4 on clinical outcomes in patients with CAD
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CXCR4 recombinant proteinPathways associated with CXCR4 recombinant protein
 Reference Product  PubMed Publications
 CXCL12 recombinant protein  >3671 publications with CXCR4 and CXCL12
 CCR5 recombinant protein  >2623 publications with CXCR4 and CCR5
 HIF1A recombinant protein  >115 publications with CXCR4 and HIF1A
 STAT3 recombinant protein  >68 publications with CXCR4 and STAT3
 JAK2 recombinant protein  >27 publications with CXCR4 and JAK2
 ITCH recombinant protein  >13 publications with CXCR4 and ITCH
 VAV1 recombinant protein  >7 publications with CXCR4 and VAV1
 UBC recombinant protein  >4 publications with CXCR4 and UBC
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Binding And Entry Of HIV Virion Pathway antibodies  Binding And Entry Of HIV Virion Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with CXCR4 recombinant proteinOrgans/Tissues associated with CXCR4 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >736 publications with CXCR4 and Inflammation
 Neoplasm Metastasis Antibodies  >704 publications with CXCR4 and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >597 publications with CXCR4 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >550 publications with CXCR4 and Disease Models, Animal
 Skin Diseases Antibodies  >524 publications with CXCR4 and Skin Diseases
 Breast Neoplasms Antibodies  >434 publications with CXCR4 and Breast Neoplasms
 Lung Diseases Antibodies  >355 publications with CXCR4 and Lung Diseases
 Necrosis Antibodies  >320 publications with CXCR4 and Necrosis
 Lung Neoplasms Antibodies  >269 publications with CXCR4 and Lung Neoplasms
 Heart Diseases Antibodies  >239 publications with CXCR4 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3944 publications with CXCR4 and Blood
 Bone Antibodies  >1818 publications with CXCR4 and Bone
 Bone Marrow Antibodies  >1586 publications with CXCR4 and Bone Marrow
 Vascular Antibodies  >1105 publications with CXCR4 and Vascular
 Brain Antibodies  >740 publications with CXCR4 and Brain
 Lung Antibodies  >566 publications with CXCR4 and Lung
 Liver Antibodies  >476 publications with CXCR4 and Liver
 Lymph Node Antibodies  >470 publications with CXCR4 and Lymph Node
 Lymph Antibodies  >460 publications with CXCR4 and Lymph
 Muscle Antibodies  >374 publications with CXCR4 and Muscle
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