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CXCL2 recombinant protein :: C-X-C motif chemokine 2 protein Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717320
SDS-PAGE
Unit / Price
0.05 mg  /  $465 +1 FREE 8GB USB
0.2 mg  /  $615 +1 FREE 8GB USB
0.5 mg  /  $680 +1 FREE 8GB USB
1 mg  /  $960 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C-X-C motif chemokine 2 protein (CXCL2), Recombinant Protein

 Also Known As   

Recombinant mouse C-X-C motif chemokine 2 protein

 Product Synonym Names    Recombinant mouse C-X-C motif chemokine 2 protein
 Product Gene Name   

CXCL2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    AVVASELRCQ CLKTLPRVDF KNIQSLSVTP PGPHCAQTEV IATLKGGQKV CLDPEAPLVQ KIIQKILNKG KAN
 Chromosome Location    Chromosome: 4; NC_000004.11 (74962752..74964997, complement). Location: 4q21
 OMIM    139110
 3D Structure    ModBase 3D Structure for P19875
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 Host    E Coli
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 Purity/Purification    0.9 (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CXCL2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CXCL2 recombinant protein

   Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst.
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 SDS-PAGE of CXCL2 recombinant protein    CXCL2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for CXCL2. It may not necessarily be applicable to this product.
 NCBI GI #    4504155
 NCBI GeneID    2920
 NCBI Accession #    NP_002080.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002089.3 [Other Products]
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 UniProt Primary Accession #    P19875 [Other Products]
 UniProt Secondary Accession #    Q6FGD6; Q9UPB8 [Other Products]
 UniProt Related Accession #    P19875 [Other Products]
 Molecular Weight    15 KD [Similar Products]
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 NCBI Official Full Name    C-X-C motif chemokine 2
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 2
 NCBI Official Symbol    CXCL2 [Similar Products]
 NCBI Official Synonym Symbols   
GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 2; gro-beta; MGSA beta; MIP2-alpha; GRO2 oncogene; growth-regulated protein beta; macrophage inflammatory protein 2-alpha; melanoma growth stimulatory activity beta
 UniProt Protein Name    C-X-C motif chemokine 2
 UniProt Synonym Protein Names   
Growth-regulated protein beta; Gro-beta; Macrophage inflammatory protein 2-alpha; MIP2-alphaCleaved into the following chain:GRO-beta(5-73); Alternative name(s):; GRO-beta-T; Hematopoietic synergistic factor; HSF; SB-251353
 Protein Family    C-X-C motif chemokine
 UniProt Gene Name    CXCL2 [Similar Products]
 UniProt Synonym Gene Names    GRO2; GROB; MIP2A; SCYB2; Gro-beta; MIP2-alpha; HSF [Similar Products]
 UniProt Entry Name    CXCL2_HUMAN
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 NCBI Summary for CXCL2    This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
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 UniProt Comments for CXCL2    Function: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Ref.9

Subcellular location: Secreted.

Post-translational modification: The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

Pharmaceutical use: GRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is used prior to hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence, duration, and/or severity of chemotherapy induced cytopenias.

Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.
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Product References and Citations for CXCL2 recombinant protein

   [1] "Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues."
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 Research Articles on CXCL2    1. Data suggest that GRObeta may function as an oncogene product and contribute to tumorigenesis and metastasis of esophageal squamous cell carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CXCL2 recombinant proteinPathways associated with CXCL2 recombinant protein
 Reference Product  PubMed Publications
 CXCR2 recombinant protein  >121 publications with CXCL2 and CXCR2
 CXCR1 recombinant protein  >18 publications with CXCL2 and CXCR1
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with CXCL2 recombinant proteinOrgans/Tissues associated with CXCL2 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >797 publications with CXCL2 and Inflammation
 Necrosis Antibodies  >563 publications with CXCL2 and Necrosis
 Respiratory Tract Diseases Antibodies  >343 publications with CXCL2 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >329 publications with CXCL2 and Lung Diseases
 Lung Injury Antibodies  >232 publications with CXCL2 and Lung Injury
 Pneumonia Antibodies  >158 publications with CXCL2 and Pneumonia
 Acute Lung Injury Antibodies  >124 publications with CXCL2 and Acute Lung Injury
 Drug Toxicity Antibodies  >115 publications with CXCL2 and Drug Toxicity
 Ischemia Antibodies  >112 publications with CXCL2 and Ischemia
 Sepsis Antibodies  >105 publications with CXCL2 and Sepsis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >874 publications with CXCL2 and Blood
 Lung Antibodies  >538 publications with CXCL2 and Lung
 Liver Antibodies  >161 publications with CXCL2 and Liver
 Bone Antibodies  >115 publications with CXCL2 and Bone
 Bone Marrow Antibodies  >100 publications with CXCL2 and Bone Marrow
 Brain Antibodies  >93 publications with CXCL2 and Brain
 Intestine Antibodies  >90 publications with CXCL2 and Intestine
 Kidney Antibodies  >79 publications with CXCL2 and Kidney
 Eye Antibodies  >45 publications with CXCL2 and Eye
 Lymph Node Antibodies  >34 publications with CXCL2 and Lymph Node
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