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PEX recombinant protein :: C-terminal hemopexin-like domain of MMP-2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142915 PEX recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,975 +4 FREE 8GB USB
 
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 Product Name   

C-terminal hemopexin-like domain of MMP-2, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human C-terminal hemopexin-like domain of MMP-2 (445-635 a.a.)

 Product Synonym Names    PEX Human; C-terminal hemopexin-like domain of MMP-2 Human Recombinant; C-terminal hemopexin-like domain of MMP-2; PEX
 Product Gene Name   

PEX recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC
 OMIM    300550
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The protein was lyophilized with 2mM Tris pH-7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the PEX in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Activity    The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF.
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 Preparation and Storage    Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution PEX should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of PEX recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PEX recombinant protein

   Description: PEX Human Recombinant is expressed as inclusion bodies in E Coli having a molecular mass of 28,453 Dalton and subsequently refolded in vitro to get biological activity.

Introduction: Recombinant Human PEX (C-terminal hemopexin-like domain of MMP-2) is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity and can inhibit cell associated collagenolytic activity both in vitro and in vivo. Moreover, PEX can block angiogenesis and tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors and the cell surface, and is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller. PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3.
 Product Categories/Family for PEX recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for PEX. It may not necessarily be applicable to this product.
 NCBI GI #    90403592
 NCBI GeneID    5251
 NCBI Accession #    NP_000435.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000444.5 [Other Products]
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 UniProt Secondary Accession #    O00678; Q13646; Q2M325; Q93032; Q99827 [Other Products]
 UniProt Related Accession #    P78562 [Other Products]
 Molecular Weight    86,474 Da
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 NCBI Official Full Name    phosphate-regulating neutral endopeptidase isoform 1
 NCBI Official Synonym Full Names    phosphate regulating endopeptidase homolog, X-linked
 NCBI Official Symbol    PHEX [Similar Products]
 NCBI Official Synonym Symbols   
HYP; PEX; XLH; HPDR; HYP1; LXHR; HPDR1
[Similar Products]
 NCBI Protein Information    phosphate-regulating neutral endopeptidase; X-linked hypophosphatemia protein; metalloendopeptidase homolog PEX; phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets); vitamin D-resistant hypophosphatemic rickets protein
 UniProt Protein Name    Phosphate-regulating neutral endopeptidase
 UniProt Synonym Protein Names   
Metalloendopeptidase homolog PEX; Vitamin D-resistant hypophosphatemic rickets protein; X-linked hypophosphatemia protein; HYP
 UniProt Gene Name    PHEX [Similar Products]
 UniProt Synonym Gene Names    PEX; HYP [Similar Products]
 UniProt Entry Name    PHEX_HUMAN
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 NCBI Summary for PEX    The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
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 UniProt Comments for PEX    PHEX: Probably involved in bone and dentin mineralization and renal phosphate reabsorption. Defects in PHEX are a cause of hypophosphatemic rickets, X-linked dominant (XLHR). XLHR is an X-linked dominant disorder characterized by impaired phosphate uptake in the kidney, which is likely to be caused by abnormal regulation of sodium phosphate cotransport in the proximal tubules. Clinical manifestations include skeletal deformities, growth failure, craniosynostosis, paravertebral calcifications, pseudofractures in lower extremities, and muscular hypotonia with onset in early childhood. X-linked hypophosphatemic rickets is the most common form of hypophosphatemia with an incidence of 1 in 20000. Belongs to the peptidase M13 family.

Protein type: EC 3.4.24.-; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.2-p22.1

Cellular Component: Golgi apparatus; integral to plasma membrane; endoplasmic reticulum; perinuclear region of cytoplasm; plasma membrane

Molecular Function: zinc ion binding; metalloendopeptidase activity; aminopeptidase activity

Biological Process: cell-cell signaling; protein modification process; organophosphate metabolic process; proteolysis; skeletal development; bone mineralization

Disease: Hypophosphatemic Rickets, X-linked Dominant
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 Research Articles on PEX    1. exon 22 is the mutation hot spot and missense mutation is the most common type of mutation in the PHEX gene in Chinese X-link dominate hypophosphatemic rickets (XLH) patients
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PEX recombinant proteinDiseases associated with PEX recombinant protein
 Reference Product  PubMed Publications
 FGF23 recombinant protein  >104 publications with PEX and FGF23
 MEPE recombinant protein  >48 publications with PEX and MEPE
 PTH recombinant protein  >37 publications with PEX and PTH
 ENPP1 recombinant protein  >15 publications with PEX and ENPP1
 SLC34A1 recombinant protein  >7 publications with PEX and SLC34A1
 SLC34A3 recombinant protein  >5 publications with PEX and SLC34A3
 SMS recombinant protein  >1 publications with PEX and SMS
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >187 publications with PEX and Kidney Diseases
 Familial Hypophosphatemic Rickets Antibodies  >137 publications with PEX and Familial Hypophosphatemic Rickets
 Disease Models, Animal Antibodies  >41 publications with PEX and Disease Models, Animal
 Abnormalities, Multiple Antibodies  >13 publications with PEX and Abnormalities, Multiple
 Nephrocalcinosis Antibodies  >8 publications with PEX and Nephrocalcinosis
 Inflammation Antibodies  >5 publications with PEX and Inflammation
 Necrosis Antibodies  >4 publications with PEX and Necrosis
 Craniofacial Abnormalities Antibodies  >4 publications with PEX and Craniofacial Abnormalities
 Weight Loss Antibodies  >3 publications with PEX and Weight Loss
 Neurobehavioral Manifestations Antibodies  >2 publications with PEX and Neurobehavioral Manifestations
Organs/Tissues associated with PEX recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >52 publications with PEX and Connective Tissue
 Embryonic Tissue Antibodies  >8 publications with PEX and Embryonic Tissue
 Lung Antibodies  >6 publications with PEX and Lung
 Intestine Antibodies  >6 publications with PEX and Intestine
 Ovary Antibodies  >4 publications with PEX and Ovary
 Thymus Antibodies  >2 publications with PEX and Thymus
 Amniotic Fluid Antibodies  >1 publications with PEX and Amniotic Fluid
 Eye Antibodies  >1 publications with PEX and Eye
 Placenta Antibodies  >1 publications with PEX and Placenta
 Uncharacterized Tissue Antibodies  >1 publications with PEX and Uncharacterized Tissue
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