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CAD recombinant protein :: CAD protein (CAD), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1242190 CAD recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $935 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $935 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,160 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,160 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,370 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,370 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,820 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,820 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CAD protein (CAD), partial, Recombinant Protein

 Also Known As   

Recombinant Human CAD protein (CAD), partial

 Product Synonym Names    CAD protein; Including the following 3 domains:; Glutamine-dependent carbamoyl-phosphate synthase; EC=6.3.5.5; Aspartate carbamoyltransferase; EC=2.1.3.2; Dihydroorotase; EC=3.5.2.3
 Product Gene Name   

CAD recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114010
 3D Structure    ModBase 3D Structure for P27708
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CAD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CAD recombinant protein

   The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
NCBI/Uniprot data below describe general gene information for CAD. It may not necessarily be applicable to this product.
 NCBI GI #    18105007
 NCBI GeneID    790
 NCBI Accession #    NP_004332.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004341.3 [Other Products]
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 UniProt Primary Accession #    P27708 [Other Products]
 UniProt Secondary Accession #    Q6P0Q0; Q96CK3; D6W552 [Other Products]
 UniProt Related Accession #    P27708 [Other Products]
 Molecular Weight    242,984 Da
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 NCBI Official Full Name    CAD protein
 NCBI Official Synonym Full Names    carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
 NCBI Official Symbol    CAD [Similar Products]
 NCBI Protein Information    CAD protein; CAD trifunctional protein; multifunctional protein CAD
 UniProt Protein Name    CAD protein
 Protein Family    CAD protein
 UniProt Gene Name    CAD [Similar Products]
 UniProt Entry Name    PYR1_HUMAN
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 NCBI Summary for CAD    The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CAD    CAD: a multifunctional enzyme that catalyzes four enzymatic activities of the pyrimidine pathway, including the rate-limiting first step. The four enzymatic activities involved in de novo pyrimidine synthesis are glutamine amidotransferase, carbamoyl-phosphate synthetase, aspartate transcarbamoylase, and dihydroorotase activities. Provides essential precursors for DNA synthesis. Required for the de novo synthesis of pyrimidine nucleotides and cell growth. Phosphorylation by p70S6K promotes CAD oligomerization, stimulating de novo synthesis of pyrimidines and progression through S phase in mammalian cells. Utilizes glutamine, bicarbonate, and aspartic acid to form a pyrimidine ring that is subsequently attached to ribose to generate a pyrimidine.

Protein type: EC 6.3.5.5; Ligase; EC 2.1.3.2; Transferase; Hydrolase; EC 3.5.2.3; Amino Acid Metabolism - alanine, aspartate and glutamate; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 2p22-p21

Cellular Component: nucleoplasm; nuclear matrix; protein complex; cell projection; membrane; cell soma; plasma membrane; terminal button; nucleus; cytosol

Molecular Function: carbamoyl-phosphate synthase (ammonia) activity; identical protein binding; enzyme binding; zinc ion binding; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; aspartate carbamoyltransferase activity; ATP binding; protein kinase activity; dihydroorotase activity

Biological Process: lactation; organ regeneration; arginine biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; heart development; UTP biosynthetic process; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation; glutamine metabolic process; response to testosterone stimulus; female pregnancy; liver development; response to caffeine; 'de novo' pyrimidine base biosynthetic process; response to cortisol stimulus; pyrimidine base metabolic process; glutamine catabolic process; pyrimidine nucleoside biosynthetic process; drug metabolic process; urea cycle; response to amine stimulus

Disease: Congenital Disorder Of Glycosylation, Type Iz
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 Research Articles on CAD    1. Recombinant aspartate carbamoyltransferase domain from the CAD enzyme complex forms homotrimers in solution.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CAD recombinant proteinPathways associated with CAD recombinant protein
 Reference Product  PubMed Publications
 CASP3 recombinant protein  >121 publications with CAD and CASP3
 MAPK1 recombinant protein  >6 publications with CAD and MAPK1
 Products by Pathway  Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Endothelin Pathway antibodies  Endothelin Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Biosynthesis Pathway antibodies  Pyrimidine Biosynthesis Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 UMP Biosynthesis Pathway antibodies  UMP Biosynthesis Pathway Diagram
Diseases associated with CAD recombinant proteinOrgans/Tissues associated with CAD recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1567 publications with CAD and Neoplasms
 Inflammation Antibodies  >857 publications with CAD and Inflammation
 Kidney Diseases Antibodies  >544 publications with CAD and Kidney Diseases
 Necrosis Antibodies  >357 publications with CAD and Necrosis
 Lung Neoplasms Antibodies  >279 publications with CAD and Lung Neoplasms
 Hypertrophy Antibodies  >274 publications with CAD and Hypertrophy
 Cardiomyopathies Antibodies  >254 publications with CAD and Cardiomyopathies
 Liver Diseases Antibodies  >212 publications with CAD and Liver Diseases
 Anemia Antibodies  >162 publications with CAD and Anemia
 Adenocarcinoma Antibodies  >142 publications with CAD and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7333 publications with CAD and Blood
 Heart Antibodies  >5925 publications with CAD and Heart
 Vascular Antibodies  >3841 publications with CAD and Vascular
 Muscle Antibodies  >939 publications with CAD and Muscle
 Bone Antibodies  >867 publications with CAD and Bone
 Lung Antibodies  >740 publications with CAD and Lung
 Kidney Antibodies  >711 publications with CAD and Kidney
 Brain Antibodies  >500 publications with CAD and Brain
 Mouth Antibodies  >425 publications with CAD and Mouth
 Liver Antibodies  >386 publications with CAD and Liver
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