NP_958742.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,300 Da
NCBI Official Full Name
CBP80/20-dependent translation initiation factor
NCBI Official Synonym Full Names
CBP80/20-dependent translation initiation factor
NCBI Official Synonym Symbols
NCBI Protein Information
CBP80/20-dependent translation initiation factor
UniProt Protein Name
CBP80/20-dependent translation initiation factor
UniProt Synonym Gene Names
UniProt Comments for Ctif
Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD) ().
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Diseases associated with Ctif recombinant protein
Organs/Tissues associated with Ctif recombinant protein
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