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CCL19 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203647
SDS-Page
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCL19, Recombinant Protein

 Also Known As   

CCL19, 22-98aa, Human, T7 tag, E Coli

 Product Synonym Names    C-C motif chemokine 19; CKb11; ELC; MIP-3b; MIP3B; SCYA19; C-C motif chemokine 19 Beta chemokine exodus 3; C C chemokine ligand 19; CC chemokine ligand 19; CCL19; Chemokine (C C motif) ligand 19; Chemokine (CC motif) ligand 19; Chemokine CC Motif Ligand 19; CK beta 11; EBI1 ligand chemokine; Exodus 3; MGC34433; MIP 3 beta; MIP3 beta; OTTHuMP00000000531; Small inducible cytokine A19
 Product Gene Name   

CCL19 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MASMTGGQQM GRGSHMGTND AEDCCLSVTQ KPIPGYIVRN FHYLLIKDGC RVPAVVFTTL RGRQLCAPPD QPWVERIIQR LQRTSAKMKR RSS
 OMIM    U77180 mRNA
 3D Structure    ModBase 3D Structure for Q99731
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In phosphate buffered saline pH7.4 containing 10% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    T7 tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of CCL19 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CCL19 recombinant protein

   CCL19 is a small cytokine belonging to the CC chemokine family that is also known as thymus and activation regulated chemokine (TARC). This protein is involved in immunoregulatory and inflammatory processes. It elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells, CCR7+ effector-memory T-Cells. Recombinant human CCL19 protein, fused to T7-tag at N-terminus, was expressed in E Coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
 Product Categories/Family for CCL19 recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for CCL19 recombinant protein   

SDS-PAGE

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 SDS-Page of CCL19 recombinant protein    CCL19 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for CCL19. It may not necessarily be applicable to this product.
 NCBI GI #    5454040
 NCBI GeneID    6363
 NCBI Accession #    NP_006265 [Other Products]
 NCBI GenBank Nucleotide #    NM_006274.2 [Other Products]
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 UniProt Primary Accession #    Q99731 [Other Products]
 UniProt Secondary Accession #    O00697; O00736 [Other Products]
 UniProt Related Accession #    Q99731 [Other Products]
 Molecular Weight    10.4 kDa (93aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    C-C motif chemokine 19
 NCBI Official Synonym Full Names    C-C motif chemokine ligand 19
 NCBI Official Symbol    CCL19 [Similar Products]
 NCBI Official Synonym Symbols   
ELC; CKb11; MIP3B; MIP-3b; SCYA19
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 19
 UniProt Protein Name    C-C motif chemokine 19
 UniProt Synonym Protein Names   
Beta-chemokine exodus-3; CK beta-11; Epstein-Barr virus-induced molecule 1 ligand chemokine; EBI1 ligand chemokine; ELC; Macrophage inflammatory protein 3 beta; MIP-3-beta; Small-inducible cytokine A19
 Protein Family    C-C motif chemokine
 UniProt Gene Name    CCL19 [Similar Products]
 UniProt Synonym Gene Names    ELC; MIP3B; SCYA19; EBI1 ligand chemokine; ELC; MIP-3-beta [Similar Products]
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 NCBI Summary for CCL19    This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]
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 UniProt Comments for CCL19    May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
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Product References and Citations for CCL19 recombinant protein

   Yoshida R, et al. (1997) J Biol Chem. 272 (21):13803-9.; Robbiani DF, et al. (2000) Cell. 103 (5):757-68.;
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 Research Articles on CCL19    1. Study confirmes that CCL19 induces the invasion and migration of breast cancer cells through the expression of markers of epithelial-mesenchymal transition.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CCL19 recombinant proteinPathways associated with CCL19 recombinant protein
 Reference Product  PubMed Publications
 CCR7 recombinant protein  >542 publications with CCL19 and CCR7
 CXCL12 recombinant protein  >161 publications with CCL19 and CXCL12
 CXCL13 recombinant protein  >119 publications with CCL19 and CXCL13
 CCL20 recombinant protein  >89 publications with CCL19 and CCL20
 CCR5 recombinant protein  >60 publications with CCL19 and CCR5
 CXCL9 recombinant protein  >45 publications with CCL19 and CXCL9
 CXCR5 recombinant protein  >36 publications with CCL19 and CXCR5
 CXCR3 recombinant protein  >31 publications with CCL19 and CXCR3
 CCRL1 recombinant protein  >16 publications with CCL19 and CCRL1
 CCRL2 recombinant protein  >4 publications with CCL19 and CCRL2
 Products by Pathway  Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
Diseases associated with CCL19 recombinant proteinOrgans/Tissues associated with CCL19 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >212 publications with CCL19 and Inflammation
 Necrosis Antibodies  >82 publications with CCL19 and Necrosis
 Lung Diseases Antibodies  >58 publications with CCL19 and Lung Diseases
 Vascular Diseases Antibodies  >47 publications with CCL19 and Vascular Diseases
 Cardiovascular Diseases Antibodies  >46 publications with CCL19 and Cardiovascular Diseases
 Hypersensitivity Antibodies  >35 publications with CCL19 and Hypersensitivity
 Death Antibodies  >25 publications with CCL19 and Death
 Liver Diseases Antibodies  >21 publications with CCL19 and Liver Diseases
 Lung Neoplasms Antibodies  >18 publications with CCL19 and Lung Neoplasms
 Breast Neoplasms Antibodies  >15 publications with CCL19 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >333 publications with CCL19 and Lymph Node
 Vascular Antibodies  >108 publications with CCL19 and Vascular
 Spleen Antibodies  >94 publications with CCL19 and Spleen
 Lung Antibodies  >83 publications with CCL19 and Lung
 Brain Antibodies  >46 publications with CCL19 and Brain
 Thymus Antibodies  >45 publications with CCL19 and Thymus
 Intestine Antibodies  >28 publications with CCL19 and Intestine
 Heart Antibodies  >24 publications with CCL19 and Heart
 Eye Antibodies  >23 publications with CCL19 and Eye
 Pancreas Antibodies  >17 publications with CCL19 and Pancreas
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