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CCL22/MDC recombinant protein

Scan QR to view Datasheet Catalog #    MBS203398
SDS-PAGE
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
0.5 mg  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCL22/MDC, Recombinant Protein

 Also Known As   

CCL22/MDC, 25-93aa, Human, His-tag, Recombinant, E Coli

 Product Synonym Names    SCYA22; STCP-1; Chemokine (C-C motif) ligand 22 / Macrophage-Derived Chemokine DC/B CK; A 152E5.1; ABCD 1; ABCD1; CC chemokine STCP 1; ccl 22; CCL22; MGC34554; Small inducible cytokine subfamily A (Cys Cys) member 22; STCP 1; STCP1; Stimulated T cell chemotactic protein 1
 Product Gene Name   

CCL22/MDC recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGPYGANMED SVCCRDYVRY RLPLRVVKHF YWTSDSCPRP GVVLLTFRDK EICADPRVPW VKMILNKLSQ
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In phosphate-buffered Saline(PBS) pH7.4, 10% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
 Endotoxin    < 1.0 Eu per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of CCL22/MDC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CCL22/MDC recombinant protein

   CCL22/MDC is a small cytokine belonging to the CC chemokine family. This protien displays chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. It interacts with cell surface chemokine receptors CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. Recombinant human CCL22/MDC, fused to His-tag at N-terminus, was expressed as insoluble protein aggregate in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
 Product Categories/Family for CCL22/MDC recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for CCL22/MDC recombinant protein   

SDS-PAGE

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 SDS-PAGE of CCL22/MDC recombinant protein    CCL22/MDC recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for CCL22/MDC. It may not necessarily be applicable to this product.
 NCBI GI #    22538804
 NCBI GeneID    6367
 NCBI Accession #    NP_002981 [Other Products]
 NCBI GenBank Nucleotide #    NM_002990.4 [Other Products]
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 UniProt Secondary Accession #    A0N0Q6; B2R4W2 [Other Products]
 UniProt Related Accession #    O00626 [Other Products]
 Molecular Weight    10.3 kDa (90aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    C-C motif chemokine 22
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 22
 NCBI Official Symbol    CCL22 [Similar Products]
 NCBI Official Synonym Symbols   
MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; A-152E5.1
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 22; CC chemokine STCP-1; MDC(1-69); macrophage-derived chemokine; small inducible cytokine A22; small inducible cytokine subfamily A (Cys-Cys), member 22; small-inducible cytokine A22; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1
 UniProt Protein Name    C-C motif chemokine 22
 UniProt Synonym Protein Names   
CC chemokine STCP-1; MDC(1-69); Macrophage-derived chemokine; Small-inducible cytokine A22; Stimulated T-cell chemotactic protein 1Cleaved into the following 3 chains:MDC(3-69); MDC(5-69); MDC(7-69)
 UniProt Gene Name    CCL22 [Similar Products]
 UniProt Synonym Gene Names    MDC; SCYA22 [Similar Products]
 UniProt Entry Name    CCL22_HUMAN
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 NCBI Summary for CCL22/MDC    This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]
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 UniProt Comments for CCL22/MDC    CCL22: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Chemokine; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity

Biological Process: cell-cell signaling; response to virus; immune response; signal transduction; inflammatory response; chemotaxis
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Product References and Citations for CCL22/MDC recombinant protein

   Wang G., et al. (2009). Cancer. 115(11):2430-7
Silvano Sozzani., et al. (2000). Journal of Leukocyte Biology. 68:400-404
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 Research Articles on CCL22/MDC    1. Suggest that lower CCL22 levels may play an important role in the pathogenesis of multiple sclerosis in women.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CCL22/MDC recombinant proteinPathways associated with CCL22/MDC recombinant protein
 Reference Product  PubMed Publications
 CCL17 recombinant protein  >352 publications with CCL22/MDC and CCL17
 CCR4 recombinant protein  >223 publications with CCL22/MDC and CCR4
 CXCR3 recombinant protein  >44 publications with CCL22/MDC and CXCR3
 CCR7 recombinant protein  >41 publications with CCL22/MDC and CCR7
 CCR5 recombinant protein  >41 publications with CCL22/MDC and CCR5
 CCR3 recombinant protein  >27 publications with CCL22/MDC and CCR3
 CCR8 recombinant protein  >25 publications with CCL22/MDC and CCR8
 CCR1 recombinant protein  >17 publications with CCL22/MDC and CCR1
 CCR2 recombinant protein  >16 publications with CCL22/MDC and CCR2
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Diseases associated with CCL22/MDC recombinant proteinOrgans/Tissues associated with CCL22/MDC recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >186 publications with CCL22/MDC and Inflammation
 Hypersensitivity Antibodies  >142 publications with CCL22/MDC and Hypersensitivity
 Skin Diseases Antibodies  >123 publications with CCL22/MDC and Skin Diseases
 Respiratory Tract Diseases Antibodies  >118 publications with CCL22/MDC and Respiratory Tract Diseases
 Lung Diseases Antibodies  >102 publications with CCL22/MDC and Lung Diseases
 Necrosis Antibodies  >74 publications with CCL22/MDC and Necrosis
 Dermatitis, Atopic Antibodies  >71 publications with CCL22/MDC and Dermatitis, Atopic
 Respiratory Hypersensitivity Antibodies  >63 publications with CCL22/MDC and Respiratory Hypersensitivity
 Carcinoma Antibodies  >45 publications with CCL22/MDC and Carcinoma
 Liver Diseases Antibodies  >17 publications with CCL22/MDC and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >488 publications with CCL22/MDC and Blood
 Thymus Antibodies  >135 publications with CCL22/MDC and Thymus
 Skin Antibodies  >124 publications with CCL22/MDC and Skin
 Lung Antibodies  >105 publications with CCL22/MDC and Lung
 Bone Antibodies  >48 publications with CCL22/MDC and Bone
 Kidney Antibodies  >13 publications with CCL22/MDC and Kidney
 Eye Antibodies  >10 publications with CCL22/MDC and Eye
 Mouth Antibodies  >3 publications with CCL22/MDC and Mouth
 Pharynx Antibodies  >3 publications with CCL22/MDC and Pharynx
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