NP_002981
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10.3 kDa (90aa), confirmed by MALDI-TOF.
NCBI Official Full Name
C-C motif chemokine 22
NCBI Official Synonym Full Names
C-C motif chemokine ligand 22
NCBI Official Synonym Symbols
MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; A-152E5.1 [Similar Products]
NCBI Protein Information
C-C motif chemokine 22
UniProt Protein Name
C-C motif chemokine 22
UniProt Synonym Protein Names
CC chemokine STCP-1; MDC(1-69); Macrophage-derived chemokine; Small-inducible cytokine A22; Stimulated T-cell chemotactic protein 1
UniProt Synonym Gene Names
NCBI Summary for CCL22/MDC
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]
UniProt Comments for CCL22/MDC
May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.
Product References and Citations for CCL22/MDC recombinant protein
Wang G., et al. (2009). Cancer. 115 (11):2430-7; Silvano Sozzani., et al. (2000). Journal of Leukocyte Biology. 68:400-404;
Research Articles on CCL22/MDC
Precautions
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Disclaimer
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Products associated with CCL22/MDC recombinant protein
Pathways associated with CCL22/MDC recombinant protein
Diseases associated with CCL22/MDC recombinant protein
Organs/Tissues associated with CCL22/MDC recombinant protein
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