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CCL25 recombinant protein

Scan QR to view Datasheet Catalog #    MBS232432 CCL25 recombinant protein
Unit / Price
0.02 mg  /  $450 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCL25, Recombinant Protein

★Popular Item★
 Also Known As   

RECOMBINANT HUMAN CCL25

 Product Gene Name   

CCL25 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602565
 3D Structure    ModBase 3D Structure for O15444
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 Purity/Purification    >98% by SDS PAGE and HPLC analysis
 Form/Format    Purified recombinant protein - lyophilised
 Concentration    Approximate Protein Concentration: 0.1mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.2ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Preparation
 Activity    Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ng/ml.
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of CCL25 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CCL25 recombinant protein

   CCL25, otherwise known as TECK (thymus expressed chemokine), is a member of the intercrine beta (chemokine CC) family, specifically expressed by thymic stromal cells, which acts as a chemotactic factor for activated macrophages, thymocytes and dendritic cells, and signals through binding to the CCR9 receptor.
 Applications Tested/Suitable for CCL25 recombinant protein   

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

 Application Notes for CCL25 recombinant protein    ELISA: Minimum Dilution: 0.2; Maximum Dilution: 0.4ng/well;
Functional Assays: Minimum Dilution: 1.0; Maximum Dilution: 10.0ng/ml;
Western Blotting: Minimum Dilution: 1.5; Maximum Dilution: 3.0ng/lane
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NCBI/Uniprot data below describe general gene information for CCL25. It may not necessarily be applicable to this product.
 NCBI GI #    323098324
 NCBI GeneID    6370
 NCBI Accession #    NP_001188288.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001201359.1 [Other Products]
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 UniProt Primary Accession #    O15444 [Other Products]
 UniProt Secondary Accession #    Q96KJ7; A1L4J4; A6NI52; A8K9E7; B5MCA5 [Other Products]
 UniProt Related Accession #    O15444 [Other Products]
 Molecular Weight    14.2kD (127 amino acid residues)
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 NCBI Official Full Name    C-C motif chemokine 25 isoform 2
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 25
 NCBI Official Symbol    CCL25 [Similar Products]
 NCBI Official Synonym Symbols   
TECK; Ckb15; SCYA25
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 25; Ck beta-15; TECKvar; chemokine TECK; small inducible cytokine subfamily A (Cys-Cys), member 25; small-inducible cytokine A25; thymus expressed chemokine; thymus-expressed chemokine
 UniProt Protein Name    C-C motif chemokine 25
 UniProt Synonym Protein Names   
Chemokine TECK; Small-inducible cytokine A25; Thymus-expressed chemokine
 Protein Family    C-C motif chemokine
 UniProt Gene Name    CCL25 [Similar Products]
 UniProt Synonym Gene Names    SCYA25; TECK [Similar Products]
 UniProt Entry Name    CCL25_HUMAN
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 NCBI Summary for CCL25    This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
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 UniProt Comments for CCL25    CCL25: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Belongs to the intercrine beta (chemokine CC) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Chemokine; Secreted

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine receptor binding; chemokine activity; CCR10 chemokine receptor binding; hormone activity

Biological Process: G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; immune response; chemotaxis; positive regulation of cell-matrix adhesion; inflammatory response; leukocyte migration
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 Research Articles on CCL25    1. CCL25 is an antimicrobial protein with bacteriocidal activity against E. coli and S. aureus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CCL25 recombinant proteinPathways associated with CCL25 recombinant protein
 Reference Product  PubMed Publications
 CCR9 recombinant protein  >138 publications with CCL25 and CCR9
 CCL19 recombinant protein  >30 publications with CCL25 and CCL19
 CCL20 recombinant protein  >19 publications with CCL25 and CCL20
 CCR7 recombinant protein  >19 publications with CCL25 and CCR7
 CXCL13 recombinant protein  >12 publications with CCL25 and CXCL13
 CCR6 recombinant protein  >11 publications with CCL25 and CCR6
 CCR5 recombinant protein  >11 publications with CCL25 and CCR5
 CXCL9 recombinant protein  >5 publications with CCL25 and CXCL9
 CCL27 recombinant protein  >5 publications with CCL25 and CCL27
 CXCR5 recombinant protein  >4 publications with CCL25 and CXCR5
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
Diseases associated with CCL25 recombinant proteinOrgans/Tissues associated with CCL25 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >54 publications with CCL25 and Inflammation
 Gastrointestinal Diseases Antibodies  >37 publications with CCL25 and Gastrointestinal Diseases
 Immune System Diseases Antibodies  >29 publications with CCL25 and Immune System Diseases
 Necrosis Antibodies  >24 publications with CCL25 and Necrosis
 Liver Diseases Antibodies  >10 publications with CCL25 and Liver Diseases
 Carcinoma Antibodies  >8 publications with CCL25 and Carcinoma
 Lymphoma Antibodies  >7 publications with CCL25 and Lymphoma
 Atrophy Antibodies  >5 publications with CCL25 and Atrophy
 Neoplasms, Experimental Antibodies  >4 publications with CCL25 and Neoplasms, Experimental
 Graft vs Host Disease Antibodies  >3 publications with CCL25 and Graft vs Host Disease
 Organ/Tissue Name  Pubmed Publications
 Thymus Antibodies  >84 publications with CCL25 and Thymus
 Lung Antibodies  >9 publications with CCL25 and Lung
 Stomach Antibodies  >5 publications with CCL25 and Stomach
 Mixed Antibodies  >2 publications with CCL25 and Mixed
 Testis Antibodies  >1 publications with CCL25 and Testis
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