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CCL3 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204175
SDS-PAGE
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
0.25 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CCL3, Recombinant Protein

 Also Known As   

CCL3, 24-92aa, Mouse, His tag, E Coli

 Product Synonym Names    C-C motif chemokine 3; AI323804; G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a); MIP1-alpha; Mip1a; Scya3
 Product Gene Name   

CCL3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSMAPYGAD TPTACCFSYS RKIPRQFIVD YFETSSLCSQ PGVIFLTKRN RQICADSKET WVQEYITDLE LNA
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. In 20mM Sodium citrate buffer (pH 3.5) containing 10% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Mouse
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of CCL3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CCL3 recombinant protein

   C-C motif chemokine 3, also known as CCL3, belongs to the intercrine beta (chemokine CC) family. CCL3 has a potent chemotactic activity for eosinophils. This protein is binding to a high-affinity receptor activates calcium release in neutrophils. Recombinant mouse CCL3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for CCL3 recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for CCL3 recombinant protein   

SDS-PAGE

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 SDS-PAGE of CCL3 recombinant protein    CCL3 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for CCL3. It may not necessarily be applicable to this product.
 NCBI GI #    6755432
 NCBI GeneID    20302
 NCBI Accession #    NP_035467 [Other Products]
 NCBI GenBank Nucleotide #    NM_011337.2 [Other Products]
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 UniProt Secondary Accession #    P14096 [Other Products]
 UniProt Related Accession #    P10855 [Other Products]
 Molecular Weight    10.4 kDa (93aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    C-C motif chemokine 3
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 3
 NCBI Official Symbol    Ccl3 [Similar Products]
 NCBI Official Synonym Symbols   
Mip1a; Scya3; G0S19-1; AI323804; MIP1-(a); LD78alpha; MIP-1alpha; MIP1-alpha
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 3; L2G25B; MIP-1 alpha; MIP-1-alpha; MIP1 (a); SIS-alpha; TY-5; heparin-binding chemotaxis protein; macrophage inflammatory protein 1-alpha; macrophage inflammatory protein-1alpha; small inducible cytokine A3; small-inducible cytokine A3
 UniProt Protein Name    C-C motif chemokine 3
 UniProt Synonym Protein Names   
Heparin-binding chemotaxis protein; L2G25B; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; SIS-alpha; Small-inducible cytokine A3; TY-5
 Protein Family    C-C motif chemokine
 UniProt Gene Name    Ccl3 [Similar Products]
 UniProt Synonym Gene Names    Mip1a; Scya3; MIP-1-alpha [Similar Products]
 UniProt Entry Name    CCL3_MOUSE
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 UniProt Comments for CCL3    CCL3L1: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1- infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Chemokine; Motility/polarity/chemotaxis

Cellular Component: extracellular space; cell; extracellular region; cytosol

Molecular Function: protein binding; chemokine activity; cytokine activity

Biological Process: neutrophil chemotaxis; positive regulation of osteoclast differentiation; leukocyte chemotaxis; positive regulation of interleukin-1 beta secretion; chemotaxis; positive regulation of tumor necrosis factor production; macrophage chemotaxis; regulation of cell shape; elevation of cytosolic calcium ion concentration; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; immune response; inflammatory response; astrocyte cell migration; positive regulation of inflammatory response
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Product References and Citations for CCL3 recombinant protein

   Brown K.D., et al. (1989) J. Immunol. 142:679-687
Grove M., et al. (1990) Nucleic Acids Res. 18:5561-5561
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 Research Articles on CCL3    1. Negative modulation of PGE2 signaling reduced infection-induced anti-inflammatory cytokine polarization and enhanced inflammatory chemokines, CCL3 and CCL5.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to CCL3, 24-92aa, Mouse, His tag, E Coli
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Pathways associated with CCL3 recombinant proteinDiseases associated with CCL3 recombinant protein
 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >889 publications with CCL3 and Inflammation
 Necrosis Antibodies  >504 publications with CCL3 and Necrosis
 Disease Models, Animal Antibodies  >313 publications with CCL3 and Disease Models, Animal
 Lung Diseases Antibodies  >237 publications with CCL3 and Lung Diseases
 HIV Infections Antibodies  >188 publications with CCL3 and HIV Infections
 Cardiovascular Diseases Antibodies  >171 publications with CCL3 and Cardiovascular Diseases
 Hypersensitivity Antibodies  >105 publications with CCL3 and Hypersensitivity
 Liver Diseases Antibodies  >95 publications with CCL3 and Liver Diseases
 Fibrosis Antibodies  >79 publications with CCL3 and Fibrosis
 Pneumonia Antibodies  >72 publications with CCL3 and Pneumonia
Organs/Tissues associated with CCL3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1547 publications with CCL3 and Blood
 Bone Antibodies  >290 publications with CCL3 and Bone
 Brain Antibodies  >256 publications with CCL3 and Brain
 Bone Marrow Antibodies  >207 publications with CCL3 and Bone Marrow
 Spleen Antibodies  >111 publications with CCL3 and Spleen
 Skin Antibodies  >99 publications with CCL3 and Skin
 Lymph Node Antibodies  >93 publications with CCL3 and Lymph Node
 Joint Antibodies  >73 publications with CCL3 and Joint
 Embryonic Tissue Antibodies  >30 publications with CCL3 and Embryonic Tissue
 Thymus Antibodies  >21 publications with CCL3 and Thymus
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