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CD105/Endoglin recombinant protein :: CD105/Endoglin, soluble Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS692095
Testing Data
Unit / Price
0.025 mg  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD105/Endoglin, soluble, Recombinant Protein

★Popular Item★
 Also Known As   

Mouse CD105/Endoglin, soluble

 Product Synonym Names    Recombinant Mouse Soluble CD105/Endoglin; Cell surface MJ7/18 antigen; CD105; Endoglin
 Product Gene Name   

CD105/Endoglin recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    ERVGCDLQPV DPTRGEVTFT TSQVSEGCVA QAANAVREVH VLFLDFPGML SHLELTLQAS KQNGTETQEV FLVLVSNKNV FVKFQAPEIP LHLAYDSSLV IFQGQPRVNI TVLPSLTSRK QILDWAATKG AITSIAALDD PQSIVLQLGQ DPKAPFLCLP EAHKDMGATL EWQPRAQTPV QSCRLEGVSG HKEAYILRIL PGSEAGPRTV TVMMELSCTS GDAILILHGP PYVSWFIDIN HSMQILTTGE YSVKIFPGSK DKGVELPDTP QGLIAEARKL NASIVTSFVE LPLVSNVSLR ASSCGGVFQT TPAPVVTTPP KDTCSPVLLM SLIQPKCGNQ VMTLALNKKH VQTLQCTITG LTFWDSSCQA EDTDDHLVLS SAYSSCGMKV TAHVVSNEVI ISFPSGSPPL RKKVQCIDMD SLSFQLGLYL SPHFLQASNT IELGQQAFVQ VSVSPLTSEV TVQLDSCHLD LGPEGDMVEL IQSRTAKGSC VTLLSPSPEG DPRFSFLLRV YMVPTPTAGT LSCNLALRPS TLSQEVYKTV SMRLNIVSPD LSHHHHHH
 Chromosome Location    Chromosome: 2; NC_000068.7 (32646532..32682669). Location: 2 B; 2 22.09 cM
 3D Structure    ModBase 3D Structure for Q63961
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 Host    Insect Cells
 Species Reactivity    Mouse
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 Purity/Purification    > 90% by SDS-PAGE & silver stain
 Form/Format    Lyophilized
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 Gene    Egn
 Stabilizer    None
 Reconstitution    The lyophilized sCD105 is soluble in water and most aqueous buffers. The lyophilized sCD105 should be reconstituted in PBS or medium to a concentration not lower than 50ug/ml.
 Buffer    PBS
 Biological Activity    Not tested so far
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 Preparation and Storage    Lyophilized samples are stable for greater than six months at -20 degree C to -70 degree C. Reconstituted sCD105 should be stored in working aliquots at -20 degree C.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of CD105/Endoglin recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CD105/Endoglin recombinant protein

   A DNA sequence encoding the extracellular domain of mouse Endoglin (Met 1 - Gly 581) was expressed in insect cells. Mouse Endoglin is a disulfide-linked homodimeric protein. Based on N-terminal sequence analysis, the primary structure of recombinant mature Endoglin starts at Glu 26. Endoglin has a calculated monomeric molecular mass of 61 kDa but as a result of glycosylation, migrates at approximately 75 - 85 kDa under reducing conditions in SDS-PAGE. Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70% and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. In common with betaglycan (also named TbetaRIII), a proteoglycan that shares regions of sequence similarity, endoglin is an accessory receptor for the TGF- superfamily ligands. Endoglin does not bind ligands by itself, but does so by associating with a ligand-binding serine/threonine kinase receptor. Endoglin binds TGF-1 and TGF-3 but not TGF-2 efficiently by associating with TGF- type II receptor (TbetaRII). It interacts with activin-A and BMP-7 using either the activin type II or type IIB receptors. In the case of BMP-2 which binds directly to the type I but not the type II BMP receptor, endoglin binds via either BMPR-IA (ALK-3) or BMPR-1B (ALK-6). Although the consequence of endoglin interactions on the functions of TGF- family ligands is poorly understood, endoglin has clearly been shown to be required for angiogenesis and to play a key role in heart development. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular disorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.
 Product Categories/Family for CD105/Endoglin recombinant protein    Soluble Receptors
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 Testing Data of CD105/Endoglin recombinant protein    CD105/Endoglin recombinant protein Testing Data image
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NCBI/Uniprot data below describe general gene information for CD105/Endoglin. It may not necessarily be applicable to this product.
 NCBI GI #    226437647
 NCBI GeneID    13805
 NCBI Accession #    NP_031958.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007932.2 [Other Products]
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 UniProt Primary Accession #    Q63961 [Other Products]
 UniProt Secondary Accession #    Q61520; Q8K100 [Other Products]
 UniProt Related Accession #    Q63961 [Other Products]
 Molecular Weight    70-75 kDa
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 NCBI Official Full Name    endoglin isoform 1
 NCBI Official Synonym Full Names    endoglin
 NCBI Official Symbol    Eng [Similar Products]
 NCBI Official Synonym Symbols   
Endo; CD105; AI528660; AI662476; S-endoglin
[Similar Products]
 NCBI Protein Information    endoglin; transmembrane glycoprotein; cell surface MJ7/18 antigen
 UniProt Protein Name    Endoglin
 UniProt Synonym Protein Names   
Cell surface MJ7/18 antigen
 UniProt Gene Name    Eng [Similar Products]
 UniProt Synonym Gene Names    Edg [Similar Products]
 UniProt Entry Name    EGLN_MOUSE
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 UniProt Comments for CD105/Endoglin    Function: Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells. Ref.7

Subunit structure: Homodimer that forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Interacts with GDF2

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Endoglin is restricted to endothelial cells in all tissues except bone marrow and is also found in stromal cells within the connective tissue of intestine, stomach, heart, skeletal muscle, uterus, ovary, oviduct, testis and thymus.
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Product References and Citations for CD105/Endoglin recombinant protein

   1. Cheifetz et al., J Biol Chem 267:19027, 1992 2. Parker et al., J Bone Miner Res 18:289, 2003 3. Barbara et al., J Biol Chem 274:584, 1999 4. McAllister et al., Nature Genet 8:345, 1994 5. Chen et al., Proc Natl Acad Sci 99:15468, 2002
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 Research Articles on CD105/Endoglin    1. these results underscore the importance of endoglin in both canonical and non-canonical TGFbeta signaling pathways modulating both the activation and quiescence of the endothelium during angiogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CD105/Endoglin recombinant proteinDiseases associated with CD105/Endoglin recombinant protein
 Products by Pathway  Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6100 publications with CD105/Endoglin and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >5290 publications with CD105/Endoglin and Cardiovascular Diseases
 Neoplasms Antibodies  >3672 publications with CD105/Endoglin and Neoplasms
 Heart Diseases Antibodies  >2780 publications with CD105/Endoglin and Heart Diseases
 Disease Models, Animal Antibodies  >668 publications with CD105/Endoglin and Disease Models, Animal
 Hypertension Antibodies  >557 publications with CD105/Endoglin and Hypertension
 Inflammation Antibodies  >532 publications with CD105/Endoglin and Inflammation
 Liver Diseases Antibodies  >431 publications with CD105/Endoglin and Liver Diseases
 Atherosclerosis Antibodies  >404 publications with CD105/Endoglin and Atherosclerosis
 Necrosis Antibodies  >366 publications with CD105/Endoglin and Necrosis
Organs/Tissues associated with CD105/Endoglin recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >7333 publications with CD105/Endoglin and Heart
 Bone Antibodies  >7124 publications with CD105/Endoglin and Bone
 Brain Antibodies  >7112 publications with CD105/Endoglin and Brain
 Muscle Antibodies  >6415 publications with CD105/Endoglin and Muscle
 Skin Antibodies  >2641 publications with CD105/Endoglin and Skin
 Connective Tissue Antibodies  >2181 publications with CD105/Endoglin and Connective Tissue
 Eye Antibodies  >1859 publications with CD105/Endoglin and Eye
 Lung Antibodies  >1772 publications with CD105/Endoglin and Lung
 Liver Antibodies  >1395 publications with CD105/Endoglin and Liver
 Bone Marrow Antibodies  >1174 publications with CD105/Endoglin and Bone Marrow
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