View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List CD137 / 4-1BB / TNFRSF9 recombinant protein Catalog # MBS2546777 Unit / Price DISCONTINUEDClick here to view our similar product(s) OR click here to contact our technical support team for suitable replacement. Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name CD137 / 4-1BB / TNFRSF9, Recombinant Protein Full Product Name Recombinant Mouse CD137 / 4-1BB / TNFRSF9 Protein (Fc tag) Product Synonym Names RP23-272N19.6, 4-1BB, A930040I11Rik, AA408498, AI325004, CDw137, Cd137, ILA, Ly63 Product Gene Name CD137 / 4-1BB / TNFRSF9 recombinant protein[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Host Human Cells Purity/Purification > 90 % as determined by SDS-PAGE Form/Format Lyophilized from sterile PBS, pH 7.4 Predicted N Terminal Val 24 Endotoxin < 1.0 EU per mug of the protein as determined by the LAL method Preparation and Storage Samples are stable for up to twelve months from date of receipt at -70 degree C ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of CD137 / 4-1BB / TNFRSF9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for CD137 / 4-1BB / TNFRSF9 recombinant protein Background: CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor-associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials.Description: A DNA sequence encoding the mouse TNFRSF9 (NP_001070976.1) (Met 1-Leu 211) was fused with the Fc region of human IgG1 at the C-terminus. Application Notes for CD137 / 4-1BB / TNFRSF9 recombinant protein The secreted recombinant mouse TNFRSF9/Fc is a disulfide-linked homodimer. The reduced monomer comprises 429 amino acids and has a calculated molecular mass of 47 kDa. As a result of glycosylation, the apparent molecular mass of the monomer is approximately 65-75 kDa in SDS-PAGE under reducing conditions. SDS-PAGE of CD137 / 4-1BB / TNFRSF9 recombinant protein TOP NCBI/Uniprot data below describe general gene information for CD137 / 4-1BB / TNFRSF9. It may not necessarily be applicable to this product. NCBI GI # 117422435 NCBI GeneID 21942 NCBI Accession # NP_001070976.1 [Other Products] NCBI GenBank Nucleotide # NM_001077508.1 [Other Products] UniProt Related Accession # P20334[Other Products] Molecular Weight 27,598 Da TOP NCBI Official Full Name tumor necrosis factor receptor superfamily member 9 isoform 2 NCBI Official Synonym Full Names tumor necrosis factor receptor superfamily, member 9 NCBI Official Symbol Tnfrsf9 [Similar Products] NCBI Official Synonym Symbols ILA; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik [Similar Products] NCBI Protein Information tumor necrosis factor receptor superfamily member 9 UniProt Protein Name Tumor necrosis factor receptor superfamily member 9 UniProt Synonym Protein Names 4-1BB ligand receptor; T-cell antigen 4-1BB; CD_antigen: CD137 UniProt Gene Name Tnfrsf9 [Similar Products] UniProt Synonym Gene Names Cd137; Ila; Ly63 [Similar Products] TOP TOP UniProt Comments for CD137 / 4-1BB / TNFRSF9 TNFRSF9: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 4 E2|4 81.52 cMCellular Component: external side of plasma membrane; extracellular space; integral to plasma membraneMolecular Function: cytokine binding; receptor activity; tumor necrosis factor receptor activityBiological Process: immune response; induction of apoptosis via death domain receptors; inflammatory response; multicellular organismal development; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide Research Articles on CD137 / 4-1BB / TNFRSF9 1. CD137 Regulates NFATc1 Expression in Mouse VSMCs through TRAF6/NF-kappaB p65 Signaling Pathway. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. 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TOP Products associated with CD137 / 4-1BB / TNFRSF9 recombinant protein Reference Product PubMed Publications Tnfsf9 recombinant protein >78 publications with CD137 / 4-1BB / TNFRSF9 and Tnfsf9 Fas recombinant protein >23 publications with CD137 / 4-1BB / TNFRSF9 and Fas Traf2 recombinant protein >16 publications with CD137 / 4-1BB / TNFRSF9 and Traf2 Traf1 recombinant protein >8 publications with CD137 / 4-1BB / TNFRSF9 and Traf1 Traf3 recombinant protein >3 publications with CD137 / 4-1BB / TNFRSF9 and Traf3 Ccnd2 recombinant protein >2 publications with CD137 / 4-1BB / TNFRSF9 and Ccnd2 Birc5 recombinant protein >2 publications with CD137 / 4-1BB / TNFRSF9 and Birc5 Il1b recombinant protein >1 publications with CD137 / 4-1BB / TNFRSF9 and Il1b Lck recombinant protein >1 publications with CD137 / 4-1BB / TNFRSF9 and Lck Pathways associated with CD137 / 4-1BB / TNFRSF9 recombinant protein Products by Pathway Pathway Diagram Cytokine Signaling In Immune System Pathway antibodies Cytokine Signaling In Immune System Pathway Diagram Cytokine-cytokine Receptor Interaction Pathway antibodies Cytokine-cytokine Receptor Interaction Pathway Diagram Cytokine-cytokine Receptor Interaction Pathway antibodies Cytokine-cytokine Receptor Interaction Pathway Diagram Immune System Pathway antibodies Immune System Pathway Diagram TNFR2 Non-canonical NF-kB Pathway antibodies TNFR2 Non-canonical NF-kB Pathway Diagram TNFs Bind Their Physiological Receptors Pathway antibodies TNFs Bind Their Physiological Receptors Pathway Diagram Diseases associated with CD137 / 4-1BB / TNFRSF9 recombinant protein Disease Name Pubmed Publications Necrosis Antibodies >355 publications with CD137 / 4-1BB / TNFRSF9 and Necrosis Disease Models, Animal Antibodies >118 publications with CD137 / 4-1BB / TNFRSF9 and Disease Models, Animal Neoplasms, Experimental Antibodies >83 publications with CD137 / 4-1BB / TNFRSF9 and Neoplasms, Experimental Inflammation Antibodies >62 publications with CD137 / 4-1BB / TNFRSF9 and Inflammation Lung Diseases Antibodies >33 publications with CD137 / 4-1BB / TNFRSF9 and Lung Diseases Vascular Diseases Antibodies >26 publications with CD137 / 4-1BB / TNFRSF9 and Vascular Diseases Cardiovascular Diseases Antibodies >26 publications with CD137 / 4-1BB / TNFRSF9 and Cardiovascular Diseases Liver Diseases Antibodies >21 publications with CD137 / 4-1BB / TNFRSF9 and Liver Diseases Lung Neoplasms Antibodies >21 publications with CD137 / 4-1BB / TNFRSF9 and Lung Neoplasms Atherosclerosis Antibodies >17 publications with CD137 / 4-1BB / TNFRSF9 and Atherosclerosis Organs/Tissues associated with CD137 / 4-1BB / TNFRSF9 recombinant protein Organ/Tissue Name Pubmed Publications Blood Antibodies >587 publications with CD137 / 4-1BB / TNFRSF9 and Blood Spleen Antibodies >54 publications with CD137 / 4-1BB / TNFRSF9 and Spleen Lung Antibodies >50 publications with CD137 / 4-1BB / TNFRSF9 and Lung Liver Antibodies >38 publications with CD137 / 4-1BB / TNFRSF9 and Liver Skin Antibodies >29 publications with CD137 / 4-1BB / TNFRSF9 and Skin Eye Antibodies >13 publications with CD137 / 4-1BB / TNFRSF9 and Eye Thymus Antibodies >9 publications with CD137 / 4-1BB / TNFRSF9 and Thymus Uterus Antibodies >2 publications with CD137 / 4-1BB / TNFRSF9 and Uterus Embryonic Tissue Antibodies >2 publications with CD137 / 4-1BB / TNFRSF9 and Embryonic Tissue Mammary Gland Antibodies >1 publications with CD137 / 4-1BB / TNFRSF9 and Mammary Gland TOP © 2006-24 MyBioSource.com. 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