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CD141 recombinant protein

Scan QR to view Datasheet Catalog #    MBS232518 CD141 recombinant protein
Unit / Price
0.01 mg  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD141, Recombinant Protein

★Popular Item★
 Also Known As   

RECOMBINANT HUMAN CD141

 Product Gene Name   

CD141 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    188040
 3D Structure    ModBase 3D Structure for P07204
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 Purity/Purification    >98% by SDS PAGE and HPLC analysis
 Form/Format    Purified recombinant protein - lyophilised
 Concentration    Approximate Protein Concentration: 0.1mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.1ml distilled water Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.Further may be prepared in a buffer containing 0,1% BSA.
 Preparation    Purified recombinant CD141 expressed in HEK293 cells
 Endotoxin Level    <1EU/ug
 Buffer Solution    10mM Sodium Phosphate
 Activity    Measured by its ability to activate protein C induced cleavage of the chromogenic substrate, BOC-Asp-Pro Arg-AMC in the presence of Thrombin. The specific activity is >500 pmoles/min/ug.
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of CD141 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CD141 recombinant protein

   Recombinant Human CD141 antigen produced in HEK293 cells represents full length human CD141, otherwise known as Thrombomodulin, is a transmembrane glycoprotein specifically synthesized by endothelial cells, which plays a critical role in the activation/conversion of protein C into protein Ca, through the formation of a complex with the coagulation factor Thrombin. The subsequent cleavage and deactivation of the coagulation factors Va and factor VIIIa by protein Ca, acts to reduce Thrombin production and hence prevent further coagulation. Plasma levels of CD141 are increased in diabetes mellitus and SLE, and Thrombomodulin can correlate with the pathogenesis of the cardiovascular diseases thrombosis and atherosclerosis. Recombinant soluble Thrombomodulin contains 491 amino acid residues, including the extracellular domain of Thrombomodulin.
 Applications Tested/Suitable for CD141 recombinant protein   

Functional Assays (FN)

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NCBI/Uniprot data below describe general gene information for CD141. It may not necessarily be applicable to this product.
 NCBI GI #    4507483
 NCBI GeneID    7056
 NCBI Accession #    NP_000352.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000361.2 [Other Products]
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 UniProt Primary Accession #    P07204 [Other Products]
 UniProt Secondary Accession #    Q8IV29; Q9UC32 [Other Products]
 UniProt Related Accession #    P07204 [Other Products]
 Molecular Weight    60,329 Da
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 NCBI Official Full Name    thrombomodulin
 NCBI Official Synonym Full Names    thrombomodulin
 NCBI Official Symbol    THBD [Similar Products]
 NCBI Official Synonym Symbols   
TM; THRM; AHUS6; BDCA3; CD141; THPH12
[Similar Products]
 NCBI Protein Information    thrombomodulin; CD141 antigen; fetomodulin
 UniProt Protein Name    Thrombomodulin
 UniProt Synonym Protein Names   
Fetomodulin; CD_antigen: CD141
 UniProt Gene Name    THBD [Similar Products]
 UniProt Synonym Gene Names    THRM; TM [Similar Products]
 UniProt Entry Name    TRBM_HUMAN
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 NCBI Summary for CD141    The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD141    thrombomodulin: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THPH12). A hemostatic disorder characterized by a tendency to thrombosis. Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p11.2

Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; receptor activity; calcium ion binding

Biological Process: negative regulation of fibrinolysis; response to cAMP; negative regulation of blood coagulation; response to lipopolysaccharide; female pregnancy; signal transduction; blood coagulation; leukocyte migration; response to X-ray

Disease: Thrombophilia Due To Thrombomodulin Defect; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6
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 Research Articles on CD141    1. hMPV-infected BDCA-1(+) and BDCA-3(+) mDCs induced expansion of Th17 cells, in response to RSV, BDCA-1(+) mDCs induced expansion of Th1 cells and BDCA-3(+) mDCs induced expansion of Th2 cells and Tregs
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD141 recombinant proteinPathways associated with CD141 recombinant protein
 Reference Product  PubMed Publications
 JUN recombinant protein  >22 publications with CD141 and JUN
 PROCR recombinant protein  >8 publications with CD141 and PROCR
 PROC recombinant protein  >4 publications with CD141 and PROC
 CRP recombinant protein  >3 publications with CD141 and CRP
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway antibodies  Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway Diagram
Diseases associated with CD141 recombinant proteinOrgans/Tissues associated with CD141 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >47 publications with CD141 and Cardiovascular Diseases
 Inflammation Antibodies  >38 publications with CD141 and Inflammation
 Thrombosis Antibodies  >32 publications with CD141 and Thrombosis
 Thrombophilia Antibodies  >24 publications with CD141 and Thrombophilia
 Kidney Diseases Antibodies  >24 publications with CD141 and Kidney Diseases
 Disseminated Intravascular Coagulation Antibodies  >20 publications with CD141 and Disseminated Intravascular Coagulation
 Atypical Hemolytic Uremic Syndrome Antibodies  >14 publications with CD141 and Atypical Hemolytic Uremic Syndrome
 Nervous System Diseases Antibodies  >12 publications with CD141 and Nervous System Diseases
 Heart Diseases Antibodies  >10 publications with CD141 and Heart Diseases
 Lung Diseases Antibodies  >10 publications with CD141 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >102 publications with CD141 and Blood
 Vascular Antibodies  >47 publications with CD141 and Vascular
 Kidney Antibodies  >16 publications with CD141 and Kidney
 Lung Antibodies  >13 publications with CD141 and Lung
 Liver Antibodies  >12 publications with CD141 and Liver
 Heart Antibodies  >10 publications with CD141 and Heart
 Brain Antibodies  >8 publications with CD141 and Brain
 Bone Antibodies  >7 publications with CD141 and Bone
 Embryonic Tissue Antibodies  >6 publications with CD141 and Embryonic Tissue
 Stomach Antibodies  >5 publications with CD141 and Stomach
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