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CD200 recombinant protein :: CD200 (MOX1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS553059 CD200 recombinant protein
Unit / Price
0.02 mg  /  $220 +1 FREE 8GB USB
0.1 mg  /  $540 +1 FREE 8GB USB
0.5 mg  /  $1,915 +2 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD200 (MOX1), Recombinant Protein

 Also Known As   

Human CD200 Recombinant (MOX1)

 Product Synonym Names    Human CD200 Recombinant (MOX1) ; CD200; MOX1; MOX2; MRC; OX-2
 Product Gene Name   

CD200 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    155970
 3D Structure    ModBase 3D Structure for P41217
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 Host    HEk293 Cells
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 Purity/Purification    >98%, as determined by SDS-PAGE and HPLC
 Form/Format    Recombinant CD200 is supplied as a 0.2 um filtered PBS solution, pH7.2.
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 Domain    Ig-like C2
 Host Note    Optimized DNA sequence encoding Human extracellular domain of human CD200 including a C-terminal 6His tag was expressed in HEK293 cells.
 Endotoxin    Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
 Molecular Weight Note    Recombinant CD200 is a monomer protein consisting of 213 amino acid residue subunits, due to glycosylation migrates as an approximately 40-45kDa protein on SDS-PAGE.
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 Preparation and Storage    Recombinant CD200, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of CD200 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CD200 recombinant protein

   CD200 is a member of the immunoglobulin type 1 superfamily that is highly expressed in the central nervous system, dendritic cells, and lymphocytes. CD200 is functionally involved in an immunosuppressive signaling pathway via interaction with its receptor, CD200R, with downstream effects of macrophage inhibition, induction of regulatory T cells, and inhibition of tumor-specific T cells. In addition to being expressed in normal tissues, CD200 has also been demonstrated in solid tumors5 and hematologic malignancies, such as acute leukemias, chronic lymphocytic leukemia/small lymphocytic lymphoma, hairy cell leukemia, mediastinal large B-cell lymphoma, classic Hodgkin lymphoma, and angioimmunoblastic T-cell lymphoma. In addition, neoplastic plasma cells frequently upregulate CD200 expression, as demonstrated by the large proportion of CD200+ plasma cell myeloma (PCM) cases (approximately 70%) found on gene expression profiling and flow cytometry. In contrast, normal plasma cells are CD200.
 Product Categories/Family for CD200 recombinant protein    Receptors CD
NCBI/Uniprot data below describe general gene information for CD200. It may not necessarily be applicable to this product.
 NCBI GI #    90903245
 NCBI GeneID    4345
 NCBI Accession #    NP_001004196.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001004196.2 [Other Products]
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 UniProt Primary Accession #    P41217 [Other Products]
 UniProt Secondary Accession #    Q6J2Q6; Q6PIQ4; Q8TB85; Q9H3J3; B3KQI1; B4DLW9; D3DN65 [Other Products]
 UniProt Related Accession #    P41217 [Other Products]
 Molecular Weight    31,264 Da
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 NCBI Official Full Name    OX-2 membrane glycoprotein isoform b
 UniProt Protein Name    OX-2 membrane glycoprotein
 Protein Family    OX-2 membrane glycoprotein
 UniProt Gene Name    CD200 [Similar Products]
 UniProt Synonym Gene Names    MOX1; MOX2 [Similar Products]
 UniProt Entry Name    OX2G_HUMAN
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 NCBI Summary for CD200    The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD200    CD200: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q13.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: regulation of immune response
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Product References and Citations for CD200 recombinant protein

   CD200 is preferentially expressed in cd138 dim multiple myeloma cells: implications for a myeloma stem cell subpopulation with potential immune-resistance. .Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 4877.
essential roles for dok2 and rasgap in CD200 receptor-mediated regulation of human myeloid cells .J. Immunol., Oct 2009; 183: 4879 - 4886.
lack of CD200 enhances pathological t cell responses during influenza infection .J. Immunol., Aug 2009; 183: 1990 - 1996.
expression of a CD200 transgene is necessary for induction but not maintenance of tolerance to cardiac and skin allografts .J. Immunol., Aug 2009; 183: 1560 - 1568.
induction of CD200 signalling reduces inflammatory cell infiltration and inhibits laser-induced choroidal neovascularization .Invest. Ophthalmol. Vis. Sci., Apr 2009; 50: 3759.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD200 recombinant proteinPathways associated with CD200 recombinant protein
 Reference Product  PubMed Publications
 CD200R1 recombinant protein  >39 publications with CD200 and CD200R1
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Diseases associated with CD200 recombinant proteinOrgans/Tissues associated with CD200 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >43 publications with CD200 and Inflammation
 Neoplasms Antibodies  >35 publications with CD200 and Neoplasms
 Leukemia Antibodies  >21 publications with CD200 and Leukemia
 Central Nervous System Diseases Antibodies  >19 publications with CD200 and Central Nervous System Diseases
 Skin Diseases Antibodies  >11 publications with CD200 and Skin Diseases
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >8 publications with CD200 and Encephalomyelitis, Autoimmune, Experimental
 Arthritis, Experimental Antibodies  >7 publications with CD200 and Arthritis, Experimental
 Lymphoma Antibodies  >7 publications with CD200 and Lymphoma
 Neurodegenerative Diseases Antibodies  >7 publications with CD200 and Neurodegenerative Diseases
 Male Urogenital Diseases Antibodies  >4 publications with CD200 and Male Urogenital Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >97 publications with CD200 and Blood
 Skin Antibodies  >43 publications with CD200 and Skin
 Brain Antibodies  >39 publications with CD200 and Brain
 Bone Marrow Antibodies  >27 publications with CD200 and Bone Marrow
 Spleen Antibodies  >24 publications with CD200 and Spleen
 Lymph Node Antibodies  >17 publications with CD200 and Lymph Node
 Vascular Antibodies  >12 publications with CD200 and Vascular
 Lung Antibodies  >11 publications with CD200 and Lung
 Kidney Antibodies  >10 publications with CD200 and Kidney
 Eye Antibodies  >10 publications with CD200 and Eye
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