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CD34 recombinant protein

Scan QR to view Datasheet Catalog #    MBS553065 CD34 recombinant protein
Unit / Price
0.01 mg  /  $220 +1 FREE 8GB USB
0.05 mg  /  $595 +1 FREE 8GB USB
0.5 mg  /  $4,180 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD34, Recombinant Protein

 Also Known As   

Human CD34 Recombinant

 Product Synonym Names    CD34; CD-34
 Product Gene Name   

CD34 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    142230
 3D Structure    ModBase 3D Structure for P28906
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 Host    HEk293 Cells
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 Purity/Purification    >95%, as determined by SDS-PAGE and HPLC
 Form/Format    Recombinant CD34 is supplied as a 0.2 um filtered PBS solution, pH7.2.
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 Host Note    Optimized DNA sequence encoding Human extracellular domain of human CD34 including a C-terminal 6His tag was expressed in HEK293 cells.
 Endotoxin    Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers
 Molecular Weight Note    Recombinant CD34 is a monomer protein consisting of 270 amino acid residue subunits, due to glycosylation migrates as an approximately 50 kDa protein on SDS-PAGE.
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 Preparation and Storage    The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of CD34 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CD34 recombinant protein

   CD34 is a transmembrane glycoprotein expressed by human hematopoietic progenitor cells of lymphoid and myeloid lineage, and various types of colony-forming activity in human bone marrow (BM), cord blood (CB), and mobilized peripheral blood (PB) are contained in the CD34+ population. It has been suggested that CD34 also defines a normally occurring population of dendritic cells within the endoneurium of peripheral nerves that is distinct from fibroblasts and conventional Schwann cells
 Product Categories/Family for CD34 recombinant protein    Receptors CD
NCBI/Uniprot data below describe general gene information for CD34. It may not necessarily be applicable to this product.
 NCBI GI #    68342038
 NCBI GeneID    947
 NCBI Accession #    NP_001020280.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025109.1 [Other Products]
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 UniProt Primary Accession #    P28906 [Other Products]
 UniProt Secondary Accession #    Q15970; Q15971; Q5JTA3; Q5JTA4; Q9UJB1; A8K664 [Other Products]
 UniProt Related Accession #    P28906; Q3C1E7; Q5JTA5; Q7Z375; Q8IUM0; Q9UH97 [Other Products]
 Molecular Weight    40,716 Da
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 NCBI Official Full Name    hematopoietic progenitor cell antigen CD34 isoform a
 UniProt Protein Name    Hematopoietic progenitor cell antigen CD34
 Protein Family    Hematopoietic progenitor cell antigen
 UniProt Gene Name    CD34 [Similar Products]
 UniProt Entry Name    CD34_HUMAN
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 NCBI Summary for CD34    The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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 UniProt Comments for CD34    CD34: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: intercellular bridge; integral to plasma membrane; lysosome; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; basal plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: sulfate binding; carbohydrate binding; transcription factor binding

Biological Process: positive regulation of odontogenesis; regulation of immune response; negative regulation of nitric oxide biosynthetic process; glomerular filtration; cell motility involved in cell locomotion; negative regulation of blood coagulation; negative regulation of tumor necrosis factor production; signal transduction; positive regulation of interleukin-10 production; cell proliferation; positive regulation of angiogenesis; cell-cell adhesion; endothelial cell proliferation; regulation of blood pressure; tissue homeostasis; hemopoiesis; leukocyte migration
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Product References and Citations for CD34 recombinant protein

   loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability .J. Immunol., Feb 2010; 184: 1292 - 1299.
a gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib .Blood, Jan 2010; 115: 315 - 325.
in vitro–differentiated t/natural killer–cell progenitors derived from human CD34+ cells mature in the thymus .Blood, Jan 2010; 115: 261 - 264.
human CD34+ cells engineered to express membrane-bound tumor necrosis factor-related apoptosis-inducing ligand (trail) target both tumor cells and tumor vasculature .Blood, Jan 2010; 10.1182/blood-2009-08-239632.
leukemia initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34- fraction .Blood, Jan 2010; 10.1182/blood-2009-02-206565.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD34 recombinant proteinPathways associated with CD34 recombinant protein
 Reference Product  PubMed Publications
 CRKL recombinant protein  >20 publications with CD34 and CRKL
 PRKCD recombinant protein  >5 publications with CD34 and PRKCD
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Diseases associated with CD34 recombinant proteinOrgans/Tissues associated with CD34 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9610 publications with CD34 and Neoplasms
 Leukemia Antibodies  >4199 publications with CD34 and Leukemia
 Leukemia, Myeloid Antibodies  >2791 publications with CD34 and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >1954 publications with CD34 and Leukemia, Myeloid, Acute
 Vascular Diseases Antibodies  >1604 publications with CD34 and Vascular Diseases
 Recurrence Antibodies  >1035 publications with CD34 and Recurrence
 Adenocarcinoma Antibodies  >692 publications with CD34 and Adenocarcinoma
 Skin Neoplasms Antibodies  >600 publications with CD34 and Skin Neoplasms
 Myelodysplastic Syndromes Antibodies  >574 publications with CD34 and Myelodysplastic Syndromes
 Head and Neck Neoplasms Antibodies  >545 publications with CD34 and Head and Neck Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13548 publications with CD34 and Blood
 Bone Antibodies  >7819 publications with CD34 and Bone
 Bone Marrow Antibodies  >7427 publications with CD34 and Bone Marrow
 Vascular Antibodies  >3845 publications with CD34 and Vascular
 Muscle Antibodies  >1855 publications with CD34 and Muscle
 Umbilical Cord Antibodies  >1341 publications with CD34 and Umbilical Cord
 Liver Antibodies  >1265 publications with CD34 and Liver
 Skin Antibodies  >1141 publications with CD34 and Skin
 Lung Antibodies  >800 publications with CD34 and Lung
 Heart Antibodies  >687 publications with CD34 and Heart
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