NP_001766.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,328 Da
NCBI Official Full Name
ADP-ribosyl cyclase 1
UniProt Protein Name
ADP-ribosyl cyclase 1
UniProt Synonym Protein Names
Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10
UniProt Synonym Gene Names
UniProt Entry Name
CD38_HUMAN
NCBI Summary for CD38
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
UniProt Comments for CD38
CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.4.99.20; Lyase; Hydrolase; Apoptosis; EC 3.2.2.6; Membrane protein, integral; Cell surface; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cell cycle regulation
Chromosomal Location of Human Ortholog: 4p15
Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; nucleus
Molecular Function: transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity
Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of B cell proliferation; positive regulation of vasoconstriction; response to hypoxia; response to progesterone stimulus; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; negative regulation of apoptosis
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Products associated with CD38 recombinant protein
Pathways associated with CD38 recombinant protein
Diseases associated with CD38 recombinant protein
Disease Name |
Pubmed Publications |
Neoplasms Antibodies |
>1515 publications with CD38 and Neoplasms |
Lymphoma Antibodies |
>405 publications with CD38 and Lymphoma |
Vascular Diseases Antibodies |
>333 publications with CD38 and Vascular Diseases |
Lymphoma, B-Cell Antibodies |
>244 publications with CD38 and Lymphoma, B-Cell |
Leukemia, Myeloid, Acute Antibodies |
>241 publications with CD38 and Leukemia, Myeloid, Acute |
Inflammation Antibodies |
>142 publications with CD38 and Inflammation |
Lymphoma, T-Cell Antibodies |
>93 publications with CD38 and Lymphoma, T-Cell |
Anemia Antibodies |
>80 publications with CD38 and Anemia |
Bone Marrow Neoplasms Antibodies |
>64 publications with CD38 and Bone Marrow Neoplasms |
Cell Transformation, Neoplastic Antibodies |
>62 publications with CD38 and Cell Transformation, Neoplastic |
Organs/Tissues associated with CD38 recombinant protein
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