NP_037259.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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Molecular Weight
34,436 Da
NCBI Official Full Name
ADP-ribosyl cyclase 1
UniProt Protein Name
ADP-ribosyl cyclase 1
UniProt Synonym Protein Names
CD38H; Cyclic ADP-ribose hydrolase 1
UniProt Synonym Gene Names
UniProt Entry Name
CD38_RAT
NCBI Summary for CD38
ADP-ribosyl cyclase enzyme involved in regulation of cellular calcium levels [RGD, Feb 2006]
UniProt Comments for CD38
CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Cell cycle regulation; Lyase; Membrane protein, integral; Cell surface; Apoptosis; EC 3.2.2.6; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.4.99.20
Cellular Component: cell surface; membrane; intracellular membrane-bound organelle; plasma membrane; integral to membrane; nucleus
Molecular Function: transferase activity; phosphorus-oxygen lyase activity; hydrolase activity, acting on glycosyl bonds; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity
Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; response to hormone stimulus; positive regulation of insulin secretion; female pregnancy; positive regulation of cell growth; response to estradiol stimulus; elevation of cytosolic calcium ion concentration; B cell receptor signaling pathway; response to hydroperoxide; response to cytokine stimulus; response to hypoxia; positive regulation of vasoconstriction; positive regulation of B cell proliferation; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; response to progesterone stimulus; negative regulation of apoptosis
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