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CD40 Ligand recombinant protein

Scan QR to view Datasheet Catalog #    MBS553154 CD40 Ligand recombinant protein
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD40 Ligand, Recombinant Protein

★Popular Item★
 Also Known As   

Human CD40 Ligand Recombinant

 Product Synonym Names    cd40l; cd40 ligand; trap; cd40lg; CD154; TNFSF5
 Product Gene Name   

CD40 Ligand recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MIETYNQTSP RSAATGLPIS MKIFMYLLTV FLITQMIGSA LFAVYLHRRL DKIEDERNLH EDFVFMKTIQ RCNTGERSLS LLNCEEIKSQ FEGFVKDIML NKEETKKENS FEMQKGDQNP QIAAHVISEA SSKTTSVLQW AEKGYYTMSN NLVTLENGKQ LTVKRQGLYY IYAQVTFCSN REASSQAPFI ASLCLKSPGR FERILLRAAN THSSAKPCGQ QSIHLGGVFE LQPGASVFVN VTDPSQVSHG TGFTSFGLLK L
 OMIM    300386
 3D Structure    ModBase 3D Structure for P29965
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 Host    E Coli
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 Purity/Purification    >98%, as determined by SDS-PAGE and HPLC
 Form/Format    Recombinant tPA was lyophilized from a 1 mg/mL 0.2 um filtered solution containing 0.2M L-arginine, 0.1M phosporic acid.
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 Source    Optimized DNA sequence encoding Human Tissue Plasminogen Activator mature chain was expressed in Chinese Hamster Ovary cells.
 Molecular Weight    Native human Tissue plasminogen Activator,generated by the proteolytic removal of the signal peptide and propeptide, has a calculated molecular mass of approcimately 55 kDa. Recombinant tPA is a disulfide-linked monomer protein consisting 527 amino acid residue subunits, and migrates due to glycosylation as an approcimately 60 kDa protein under non-reducing conditions in SDS-PAGE.
 Endotoxin    Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
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 Preparation and Storage    The lyophilized protein is stable for at least 2 years from date of receipt at -20C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2-8C for one month, or at -20C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of CD40 Ligand recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CD40 Ligand recombinant protein

   CD40 protein is expressed on all B-lymphocytes during various stages of development, activated T- cells and monocytes, follicular dendritic cells, thymic epithelial cells, and various carcinoma cell lines. It is expressed on most mature B-cell malignancies and on some early B-cell acute lymphocytic leukemias. Human CD40 has been found to be the receptor for a protein involved in an X- linked immunodeficiency syndrome. The CD40 ligand is identical with a T-cell restricted cell surface activation antigen designated 5c8. The mouse ligand of CD40 is gp39.Based on its homology with other members of the TNF ligand protein superfamily the protein is referred to also as TNFSF5.
 Product Categories/Family for CD40 Ligand recombinant protein    Cytokines
NCBI/Uniprot data below describe general gene information for CD40 Ligand. It may not necessarily be applicable to this product.
 NCBI GI #    4557433
 NCBI GeneID    959
 NCBI Accession #    NP_000065.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000074.2 [Other Products]
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 UniProt Primary Accession #    P29965 [Other Products]
 UniProt Related Accession #    P29965; Q3L8U2; Q3LFI8; Q45QX2 [Other Products]
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 NCBI Official Full Name    CD40 ligand
 UniProt Protein Name    CD40 ligand
 UniProt Synonym Protein Names   
T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5
 Protein Family    CD40 ligand
 UniProt Gene Name    CD40LG [Similar Products]
 UniProt Synonym Gene Names    CD40L; TNFSF5; TRAP; CD40-L; TRAP [Similar Products]
 UniProt Entry Name    CD40L_HUMAN
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 NCBI Summary for CD40 Ligand    The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD40 Ligand    CD40LG: Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1); also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. Belongs to the tumor necrosis factor family.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: Xq26

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: CD40 receptor binding; cytokine activity; tumor necrosis factor receptor binding

Biological Process: B cell proliferation; platelet activation; regulation of immune response; leukocyte adhesion; positive regulation of interleukin-12 production; B cell differentiation; immunoglobulin secretion; isotype switching; inflammatory response; regulation of immunoglobulin secretion; negative regulation of apoptosis

Disease: Immunodeficiency With Hyper-igm, Type 1
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Product References and Citations for CD40 Ligand recombinant protein

   the cd40/CD40 Ligand system: linking inflammation with atherothrombosis .J. Am. Coll. Cardiol., Aug 2009; 54: 669 - 677.
growth inhibition of human multiple myeloma cells by an oncolytic adenovirus carrying the CD40 Ligand transgene .Clin. Cancer Res., Aug 2009; 15: 4847 - 4856.
matrix metalloproteinase 9 is involved in crohn’s disease-associated platelet hyperactivation through the release of soluble CD40 Ligand .Gut, Jul 2009; 58: 920 - 928.
distinct roles of cd28- and CD40 Ligand-mediated costimulation in the development of protective immunity and pathology during chlamydia muridarum urogenital infection in mice .Infect. Immun., Jul 2009; 77: 3080 - 3089.
phase i study of intranodal direct injection of adenovirus encoding recombinant cd40-ligand (ad-isf35) in patients with chronic lymphocytic leukemia .ASCO Meeting Abstracts, May 2009; 27: 3003.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD40 Ligand recombinant proteinPathways associated with CD40 Ligand recombinant protein
 Reference Product  PubMed Publications
 CD40 recombinant protein  >14 publications with CD40 Ligand and CD40
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
Diseases associated with CD40 Ligand recombinant proteinOrgans/Tissues associated with CD40 Ligand recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with CD40 Ligand and Inflammation
 Genetic Diseases, Inborn Antibodies  >3 publications with CD40 Ligand and Genetic Diseases, Inborn
 Skin Diseases Antibodies  >2 publications with CD40 Ligand and Skin Diseases
 Cardiovascular Diseases Antibodies  >2 publications with CD40 Ligand and Cardiovascular Diseases
 Vascular Diseases Antibodies  >2 publications with CD40 Ligand and Vascular Diseases
 Myocardial Ischemia Antibodies  >2 publications with CD40 Ligand and Myocardial Ischemia
 Neutropenia Antibodies  >2 publications with CD40 Ligand and Neutropenia
 Neoplasms Antibodies  >2 publications with CD40 Ligand and Neoplasms
 Erythema Antibodies  >1 publications with CD40 Ligand and Erythema
 Peritonitis Antibodies  >1 publications with CD40 Ligand and Peritonitis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with CD40 Ligand and Blood
 Mixed Antibodies  >1 publications with CD40 Ligand and Mixed
 Thymus Antibodies  >1 publications with CD40 Ligand and Thymus
 Brain Antibodies  >1 publications with CD40 Ligand and Brain
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