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Cd40lg recombinant protein :: CD40 ligand (Cd40lg) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS948098 Cd40lg recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD40 ligand (Cd40lg), Recombinant Protein

 Also Known As   

Recombinant Mouse CD40 ligand (Cd40lg)

 Product Synonym Names    CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5; CD_antigen=; CD154Cleaved into the following 2 chains:; 1. CD40 ligand, membrane form; 2. CD40 ligand, soluble form
 Product Gene Name   

Cd40lg recombinant protein

[Similar Products]
 Product Synonym Gene Name    Cd40lg; Cd40l; Tnfsf5 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    47-260
 Sequence    HRRL DKVEEEVNLH EDFVFIKKLK RCNKGEGSLS LLNCEEMRRQ FEDLVKDITL NKEEKKENSF EMQRGDEDPQ IAAHVVSEAN SNAASVLQWA KKGYYTMKSN LVMLENGKQL TVKREGLYYV YTQVTFCSNR EPSSQRPFIV GLWLKPSSGS ERILLKAANT HSSSQLCEQQ SVHLGGVFEL QAGASVFVNV TEASQVIHRV GFSSFGLLKL
 3D Structure    ModBase 3D Structure for P27548
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Cd40lg recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Cd40lg. It may not necessarily be applicable to this product.
 NCBI GI #    15011846
 NCBI GeneID    21947
 NCBI Accession #    NP_035746.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_011616.2 [Other Products]
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 UniProt Primary Accession #    P27548 [Other Products]
 UniProt Related Accession #    P27548 [Other Products]
 Molecular Weight    29,370 Da
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 NCBI Official Full Name    CD40 ligand
 NCBI Official Synonym Full Names    CD40 ligand
 NCBI Official Symbol    Cd40lg [Similar Products]
 NCBI Official Synonym Symbols   
IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5
[Similar Products]
 NCBI Protein Information    CD40 ligand; T-cell antigen Gp39; TNF-related activation protein; tumor necrosis factor ligand superfamily member 5
 UniProt Protein Name    CD40 ligand
 UniProt Synonym Protein Names   
T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5; CD_antigen: CD154Cleaved into the following 2 chains:CD40 ligand, membrane form; CD40 ligand, soluble form
 Protein Family    CD40 ligand
 UniProt Gene Name    Cd40lg [Similar Products]
 UniProt Synonym Gene Names    Cd40l; Tnfsf5; CD40-L; TRAP [Similar Products]
 UniProt Entry Name    CD40L_MOUSE
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 UniProt Comments for Cd40lg    CD40LG: Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1); also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. Belongs to the tumor necrosis factor family.

Protein type: Membrane protein, integral; Cell adhesion

Cellular Component: extracellular space; cell surface; membrane; cell; extracellular region; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: CD40 receptor binding; cytokine activity; tumor necrosis factor receptor binding

Biological Process: B cell proliferation; platelet activation; positive regulation of interleukin-12 production; isotype switching; positive regulation of immune response to tumor cell; signal transduction; positive regulation of interleukin-10 production; positive regulation of interferon-gamma production; B cell differentiation; positive regulation of MHC class II biosynthetic process; immunoglobulin secretion; positive regulation of B cell proliferation; immune response; inflammatory response; regulation of immunoglobulin secretion; negative regulation of apoptosis
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 Research Articles on Cd40lg    1. expression of CD40L in an earlier developmental step may be determinant in the regulation of the class switch recombination process
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Cd40lg recombinant proteinPathways associated with Cd40lg recombinant protein
 Reference Product  PubMed Publications
 Cd40 recombinant protein  >27 publications with Cd40lg and Cd40
 Cd86 recombinant protein  >4 publications with Cd40lg and Cd86
 Icam1 recombinant protein  >4 publications with Cd40lg and Icam1
 Traf1 recombinant protein  >2 publications with Cd40lg and Traf1
 Cd80 recombinant protein  >2 publications with Cd40lg and Cd80
 Foxp3 recombinant protein  >1 publications with Cd40lg and Foxp3
 Tnfsf13b recombinant protein  >1 publications with Cd40lg and Tnfsf13b
 Il2 recombinant protein  >1 publications with Cd40lg and Il2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with Cd40lg recombinant proteinOrgans/Tissues associated with Cd40lg recombinant protein
 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >11 publications with Cd40lg and Autoimmune Diseases
 Inflammation Antibodies  >9 publications with Cd40lg and Inflammation
 Necrosis Antibodies  >6 publications with Cd40lg and Necrosis
 Cardiovascular Diseases Antibodies  >4 publications with Cd40lg and Cardiovascular Diseases
 Myocardial Infarction Antibodies  >3 publications with Cd40lg and Myocardial Infarction
 Hyper-IgM Immunodeficiency Syndrome, Type 1 Antibodies  >3 publications with Cd40lg and Hyper-IgM Immunodeficiency Syndrome, Type 1
 Myocardial Ischemia Antibodies  >3 publications with Cd40lg and Myocardial Ischemia
 Pneumonia Antibodies  >3 publications with Cd40lg and Pneumonia
 Heart Diseases Antibodies  >3 publications with Cd40lg and Heart Diseases
 Kidney Diseases Antibodies  >2 publications with Cd40lg and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >17 publications with Cd40lg and Blood
 Mixed Antibodies  >1 publications with Cd40lg and Mixed
 Thymus Antibodies  >1 publications with Cd40lg and Thymus
 Brain Antibodies  >1 publications with Cd40lg and Brain
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