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| Product Name
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CD40, Recombinant Protein ★Popular Item★
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| Also Known As
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CD40, 21-193aa, Human, His tag, E Coli
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| Product Synonym Names
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CD40 molecule TNF receptor superfamily member 5; CD40 molecule; TNF receptor superfamily member 5; Bp50; CDW40; p50; TNFRSF5
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Sequence
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MGSSHHHHHH SSGLVPRGSH MGSEPPTACR EKQYLINSQC CSLCQPGQKL VSDCTEFTET ECLPCGESEF LDTWNRETHC HQHKYCDPNL GLRVQQKGTS ETDTICTCEE GWHCTSEACE SCVLHRSCSP GFGVKQIATG VSDTICEPCP VGFFSNVSSA FEKCHPWTSC ETKDLVVQQA GTNKTDVVCG PQDRLR
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| OMIM
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X60592 mRNA
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| 3D Structure
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ModBase 3D Structure for P25942
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| Host
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E Coli
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| Purity/Purification
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> 90% by SDS-PAGE
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| Form/Format
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Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
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| Concentration
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0.25 mg/ml (determined by Bradford assay) (lot specific)
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| Antigen Species
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Human
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| Tag Information
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His-tag
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| Preparation and Storage
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Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
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| Other Notes
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Small volumes of CD40 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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CD40 is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Recombinant human CD40 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
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| Product Categories/Family for CD40 recombinant protein
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Stem cell
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| Applications Tested/Suitable for CD40 recombinant protein
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SDS-PAGE
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| SDS-Page of CD40 recombinant protein
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TOP
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| NCBI/Uniprot data below describe general gene information for CD40. It may not necessarily be applicable to this product. |
| NCBI GI #
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4507581
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| NCBI GeneID
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958
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| NCBI Accession #
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NP_001241
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001250.5
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[Other Products]
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| UniProt Primary Accession #
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P25942
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[Other Products]
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| UniProt Secondary Accession #
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Q53GN5; Q5JY15; Q5U007; Q7M4Q8; Q86YK5; Q9BYU0; E1P5S9
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[Other Products]
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| UniProt Related Accession #
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P25942
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[Other Products]
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| Molecular Weight
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21.6 kDa (196aa) confirmed by MALDI-TOF
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TOP
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| NCBI Official Full Name
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tumor necrosis factor receptor superfamily member 5 isoform 1
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| NCBI Official Synonym Full Names
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CD40 molecule
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| NCBI Official Symbol
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CD40
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[Similar Products]
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| NCBI Official Synonym Symbols
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p50; Bp50; CDW40; TNFRSF5
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[Similar Products]
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| NCBI Protein Information
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tumor necrosis factor receptor superfamily member 5
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| UniProt Protein Name
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Tumor necrosis factor receptor superfamily member 5
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| UniProt Synonym Protein Names
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B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD_antigen: CD40
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| Protein Family
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CD40 ligand
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| UniProt Gene Name
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CD40
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[Similar Products]
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| UniProt Synonym Gene Names
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TNFRSF5
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[Similar Products]
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| NCBI Summary for CD40
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This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
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| UniProt Comments for CD40
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Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
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TOP
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Tone M., et al. (2001) Proc. Natl. Acad. Sci. u.S.A. 98:1751-1756; Khandekar S.S., et al. (2001) Protein Expr. Purif. 23:301-310;
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| Research Articles on CD40
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1. CD40 gene rs4810485 and rs1883832 mutations investigated in Recurrent aphthous stomatitis patients.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Products associated with CD40 recombinant protein | Pathways associated with CD40 recombinant protein |
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| Diseases associated with CD40 recombinant protein | Organs/Tissues associated with CD40 recombinant protein |
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TOP
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Recombinant Protein 
