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CD40 recombinant protein

Scan QR to view Datasheet Catalog #    MBS538087 CD40 recombinant protein
Unit / Price
0.01 mg  /  $180 +1 FREE 8GB USB
0.05 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD40, Recombinant Protein

★Popular Item★
 Also Known As   

CD40 protein

 Product Synonym Names    soluble CD40 Ligand protein; CD-40 protein; CD-40; CD40; CD 40; TRAP protein; TNFSF5 protein; gp39 protein; T-BAM protein; CD154 protein; CD 40 protein
 Product Gene Name   

CD40 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of CD40 protein correspond ing to amino acids MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL.
 OMIM    109535
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    Sterile filtered through a 0.2 um filter. Lyophilized from 10 mM Na3PO4, pH 7.5. Reconstitute in 5-10 mM Na3PO4, pH 7.5 to a concentration of 0.1-1.0 mg/ml.
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 Protein Type    Recombinant
 Biological Significance    CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of CD40 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CD40 recombinant protein

   Purified recombinant Human CD40 protein
 Product Categories/Family for CD40 recombinant protein    Immunology
 Applications Tested/Suitable for CD40 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for CD40. It may not necessarily be applicable to this product.
 NCBI GI #    114053977
 NCBI GeneID    958
 NCBI Accession #    ABI49511.1 [Other Products]
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 UniProt Secondary Accession #    Q53GN5; Q5JY15; Q5U007; Q7M4Q8; Q86YK5; Q9BYU0; E1P5S9 [Other Products]
 UniProt Related Accession #    P25942 [Other Products]
 Molecular Weight    16.3 kDa
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 NCBI Official Full Name    CD40, partial
 NCBI Official Synonym Full Names    CD40 molecule, TNF receptor superfamily member 5
 NCBI Official Symbol    CD40 [Similar Products]
 NCBI Official Synonym Symbols   
p50; Bp50; CDW40; TNFRSF5
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 5
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 5
 UniProt Synonym Protein Names   
B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD_antigen: CD40
 Protein Family    CD40 ligand
 UniProt Gene Name    CD40 [Similar Products]
 UniProt Synonym Gene Names    TNFRSF5 [Similar Products]
 UniProt Entry Name    TNR5_HUMAN
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 NCBI Summary for CD40    This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
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 UniProt Comments for CD40    CD40: a member of the TNF-receptor superfamily. This receptor for CD40L mediates a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3). HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. Two alternatively spliced isoforms have been reported. Isoform I is a type I membrane protein; isoform II is secreted.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20q12-q13.2

Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; signal transducer activity; enzyme binding; ubiquitin protein ligase binding; receptor activity; antigen binding

Biological Process: B cell proliferation; platelet activation; positive regulation of isotype switching to IgG isotypes; regulation of immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; immune response-regulating cell surface receptor signaling pathway; activation of NF-kappaB transcription factor; cellular calcium ion homeostasis; positive regulation of MAP kinase activity; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of B cell proliferation; protein kinase B signaling cascade; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; positive regulation of protein amino acid phosphorylation; inflammatory response; defense response to virus; regulation of immunoglobulin secretion

Disease: Immunodeficiency With Hyper-igm, Type 3
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 Research Articles on CD40    1. protease activity of Per a 10 reduces CD40 expression on DCs. CD40 down-regulation leads to low NF-kappaB levels, thereby modulating DC-mediated immune responses.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD40 recombinant proteinPathways associated with CD40 recombinant protein
 Reference Product  PubMed Publications
 TRAF2 recombinant protein  >176 publications with CD40 and TRAF2
 TRAF3 recombinant protein  >136 publications with CD40 and TRAF3
 TRAF6 recombinant protein  >117 publications with CD40 and TRAF6
 TRAF1 recombinant protein  >81 publications with CD40 and TRAF1
 TRAF5 recombinant protein  >39 publications with CD40 and TRAF5
 CD40LG recombinant protein  >32 publications with CD40 and CD40LG
 JAK3 recombinant protein  >27 publications with CD40 and JAK3
 NFKB1 recombinant protein  >14 publications with CD40 and NFKB1
 BIRC3 recombinant protein  >10 publications with CD40 and BIRC3
 BIRC2 recombinant protein  >7 publications with CD40 and BIRC2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with CD40 recombinant proteinOrgans/Tissues associated with CD40 recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2303 publications with CD40 and Necrosis
 Inflammation Antibodies  >1674 publications with CD40 and Inflammation
 Cardiovascular Diseases Antibodies  >1124 publications with CD40 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >761 publications with CD40 and Disease Models, Animal
 Atherosclerosis Antibodies  >501 publications with CD40 and Atherosclerosis
 Heart Diseases Antibodies  >478 publications with CD40 and Heart Diseases
 Neoplasms, Experimental Antibodies  >433 publications with CD40 and Neoplasms, Experimental
 Lung Diseases Antibodies  >356 publications with CD40 and Lung Diseases
 Arthritis, Rheumatoid Antibodies  >268 publications with CD40 and Arthritis, Rheumatoid
 Liver Diseases Antibodies  >206 publications with CD40 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8997 publications with CD40 and Blood
 Bone Antibodies  >1325 publications with CD40 and Bone
 Lymph Node Antibodies  >912 publications with CD40 and Lymph Node
 Lymph Antibodies  >721 publications with CD40 and Lymph
 Skin Antibodies  >611 publications with CD40 and Skin
 Lung Antibodies  >449 publications with CD40 and Lung
 Liver Antibodies  >410 publications with CD40 and Liver
 Kidney Antibodies  >376 publications with CD40 and Kidney
 Brain Antibodies  >328 publications with CD40 and Brain
 Tonsil Antibodies  >222 publications with CD40 and Tonsil
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