NP_758860
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33.8 kDa (302aa) confirmed by MALDI-TOF
NCBI Official Full Name
membrane cofactor protein isoform 14
NCBI Official Synonym Full Names
CD46 molecule
NCBI Official Synonym Symbols
MCP; TLX; AHUS2; MIC10; TRA2.10 [Similar Products]
NCBI Protein Information
membrane cofactor protein
UniProt Protein Name
Membrane cofactor protein
UniProt Synonym Protein Names
TLX; Trophoblast leukocyte common antigen; CD_antigen: CD46
UniProt Synonym Gene Names
NCBI Summary for CD46
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
UniProt Comments for CD46
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
Product References and Citations for CD46 recombinant protein
Riley R C., et al. (2002) Mol Reprod Dev. 62:534-546.; Iwata K., et al. (1995) J Biol Chem. 270:15148-15152.;
Research Articles on CD46
Precautions
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Disclaimer
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Products associated with CD46 recombinant protein
Pathways associated with CD46 recombinant protein
Diseases associated with CD46 recombinant protein
Organs/Tissues associated with CD46 recombinant protein
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