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Cd81 recombinant protein :: CD81 antigen Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS954966
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD81 antigen, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse CD81 antigen

 Product Synonym Names    26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; CD81
 Product Gene Name   

Cd81 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    116-201aa; Extracellular Domain
 Sequence    KDQIAKDVKQ FYDQALQQAV MDDDANNAKA VVKTFHETLN CCGSNALTTL TTTILRNSLC PSGGNILTPL LQQDCHQKID ELFSGK
 3D Structure    ModBase 3D Structure for P35762
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Cd81 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Cd81 recombinant protein

   May play an important role in the regulation of lymphoma cell growth. May be involved in the acrosome reaction.
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 SDS-PAGE of Cd81 recombinant protein    Cd81 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Cd81. It may not necessarily be applicable to this product.
 NCBI GI #    19526794
 NCBI GeneID    12520
 NCBI Accession #    NP_598416.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_133655.2 [Other Products]
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 UniProt Primary Accession #    P35762 [Other Products]
 UniProt Secondary Accession #    Q91V78 [Other Products]
 UniProt Related Accession #    P35762 [Other Products]
 Molecular Weight    36.8kD
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 NCBI Official Full Name    CD81 antigen
 NCBI Official Synonym Full Names    CD81 antigen
 NCBI Official Symbol    Cd81 [Similar Products]
 NCBI Official Synonym Symbols   
Tapa1; Tapa-1; Tspan28
[Similar Products]
 NCBI Protein Information    CD81 antigen
 UniProt Protein Name    CD81 antigen
 UniProt Synonym Protein Names   
26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; CD_antigen: CD81
 Protein Family    CD81 antigen
 UniProt Gene Name    Cd81 [Similar Products]
 UniProt Synonym Gene Names    Tapa1 [Similar Products]
 UniProt Entry Name    CD81_MOUSE
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 UniProt Comments for Cd81    CD81: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV. Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6); also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the tetraspanin (TM4SF) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: apical plasma membrane; focal adhesion; immunological synapse; integral to membrane; integral to plasma membrane; membrane; vesicle

Molecular Function: protein binding

Biological Process: activation of MAPK activity; cell surface receptor linked signal transduction; positive regulation of 1-phosphatidylinositol 4-kinase activity; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein localization; receptor internalization; regulation of cell proliferation; regulation of protein stability
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Product References and Citations for Cd81 recombinant protein

   Genomic organization and chromosomal localization of the TAPA-1 gene.Andria M.L., Hsieh C.L., Oren R., Francke U., Levy S.J. Immunol. 147:1030-1036(1991) Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse.Paulsen M., El-Maarri O., Engemann S., Stroedicke M., Franck O., Davies K., Reinhardt R., Reik W., Walter J.Hum. Mol. Genet. 9:1829-1841(2000) Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Duff K., Parsons J. Lubec G., Kang S.U.Submitted (APR-2007) to UniProtKB PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins.Clark K.L., Zeng Z., Langford A.L., Bowen S.M., Todd S.C.J. Immunol. 167:5115-5121(2001) Reduced fertility of female mice lacking CD81.Rubinstein E., Ziyyat A., Prenant M., Wrobel E., Wolf J.-P., Levy S., Le Naour F., Boucheix C.Dev. Biol. 290:351-358(2006) Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes.Smith R.A., Young J., Weis J.J., Weis J.H.Genes Immun. 7:113-121(2006) Possible involvement of CD81 in acrosome reaction of sperm in mice.Tanigawa M., Miyamoto K., Kobayashi S., Sato M., Akutsu H., Okabe M., Mekada E., Sakakibara K., Miyado M., Umezawa A., Miyado K.Mol. Reprod. Dev. 75:150-155(2008)
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 Research Articles on Cd81    1. CD81-Rac interaction exerts an important regulatory role on the innate and adaptive immunity against bacterial infection and suggests a role for CD81 in the development of novel therapeutic targets during infectious diseases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Cd81 recombinant proteinPathways associated with Cd81 recombinant protein
 Reference Product  PubMed Publications
 Cd19 recombinant protein  >106 publications with Cd81 and Cd19
 Scarb1 recombinant protein  >46 publications with Cd81 and Scarb1
 Igsf8 recombinant protein  >18 publications with Cd81 and Igsf8
 Ifitm1 recombinant protein  >3 publications with Cd81 and Ifitm1
 Ifitm2 recombinant protein  >1 publications with Cd81 and Ifitm2
 Ifitm3 recombinant protein  >1 publications with Cd81 and Ifitm3
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
Diseases associated with Cd81 recombinant proteinOrgans/Tissues associated with Cd81 recombinant protein
 Disease Name  Pubmed Publications
 Hepatitis C Antibodies  >550 publications with Cd81 and Hepatitis C
 Liver Diseases Antibodies  >270 publications with Cd81 and Liver Diseases
 Carcinoma Antibodies  >106 publications with Cd81 and Carcinoma
 Carcinoma, Hepatocellular Antibodies  >75 publications with Cd81 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >52 publications with Cd81 and Liver Neoplasms
 Adenocarcinoma Antibodies  >47 publications with Cd81 and Adenocarcinoma
 Liver Cirrhosis Antibodies  >46 publications with Cd81 and Liver Cirrhosis
 Inflammation Antibodies  >45 publications with Cd81 and Inflammation
 Vascular Diseases Antibodies  >30 publications with Cd81 and Vascular Diseases
 Necrosis Antibodies  >27 publications with Cd81 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >360 publications with Cd81 and Blood
 Liver Antibodies  >252 publications with Cd81 and Liver
 Bone Antibodies  >52 publications with Cd81 and Bone
 Bone Marrow Antibodies  >44 publications with Cd81 and Bone Marrow
 Brain Antibodies  >40 publications with Cd81 and Brain
 Kidney Antibodies  >28 publications with Cd81 and Kidney
 Lung Antibodies  >27 publications with Cd81 and Lung
 Lymph Node Antibodies  >20 publications with Cd81 and Lymph Node
 Muscle Antibodies  >19 publications with Cd81 and Muscle
 Skin Antibodies  >16 publications with Cd81 and Skin
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