AAI00912.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,237 Da
NCBI Official Full Name
CD8b molecule
NCBI Official Synonym Full Names
CD8b molecule
NCBI Protein Information
T-cell surface glycoprotein CD8 beta chain; CD8 antigen, beta polypeptide 1 (p37); T lymphocyte surface glycoprotein beta chain
UniProt Protein Name
T-cell surface glycoprotein CD8 beta chain
UniProt Synonym Protein Names
CD_antigen: CD8b
UniProt Synonym Gene Names
UniProt Entry Name
CD8B_HUMAN
NCBI Summary for CD8B
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
UniProt Comments for CD8B
CD8B: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2p12
Cellular Component: T cell receptor complex; early endosome membrane; integral to plasma membrane; extracellular region; plasma membrane; external side of plasma membrane
Molecular Function: protein binding; MHC class I protein binding; coreceptor activity
Biological Process: regulation of immune response; viral reproduction; T cell activation; immune response; regulation of defense response to virus by virus; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on CD8B
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Products associated with CD8B recombinant protein
Pathways associated with CD8B recombinant protein
Diseases associated with CD8B recombinant protein
Organs/Tissues associated with CD8B recombinant protein
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