NP_001253
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20.7kDa (192aa), confirmed by MALDI-TOF
NCBI Official Full Name
cyclin-dependent kinase 4 inhibitor C
NCBI Official Synonym Full Names
cyclin dependent kinase inhibitor 2C
NCBI Protein Information
cyclin-dependent kinase 4 inhibitor C
UniProt Protein Name
Cyclin-dependent kinase 4 inhibitor C
UniProt Synonym Protein Names
Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6
UniProt Synonym Gene Names
NCBI Summary for CDKN2C
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for CDKN2C
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Product References and Citations for CDKN2C recombinant protein
Blais A, et al. (1998).) Biochem Biophys Res Commun 247 (1): 146-53.; Serrano M, et al. (1994). Nature 366 (6456): 704-7.
Research Articles on CDKN2C
Precautions
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Disclaimer
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Products associated with CDKN2C recombinant protein
Pathways associated with CDKN2C recombinant protein
Diseases associated with CDKN2C recombinant protein
Organs/Tissues associated with CDKN2C recombinant protein
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