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CEBP-alpha recombinant protein

Scan QR to view Datasheet Catalog #    MBS203063
SDS-Page
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
0.5 mg  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CEBP-alpha, Recombinant Protein

 Also Known As   

CEBP-alpha (bZIPregion residues), 270-358aa, Human, His tag, E Coli

 Product Synonym Names    CCAAT/enhancer binding protein a; CEBPA; CEBP-alpha bZIPregion residues 270-358; C/EBP alpha; CCAAT/enhancer-binding protein alpha; CAAT/enhancer binding protein a; Apoptotic cysteine protease; Apoptotic protease Mch 5; CAP4; Caspase 8 precursor; CCAAT Enhancer Binding Protein alpha; CEBP; CEBP A; CEBP alpha; FADD homologous ICE/CED 3 like protease; FADD like ICE; FLICE; ICE8; MACH; MCH5; MORT1 associated CED 3 homolog
 Product Gene Name   

CEBP-alpha recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGAG KAKKSVDKNS NEYRVRRERN NIAVRKSRDK AKQRNVETQQ KVLELTSDND RLRKRVEQLS RELDTLRGIF RQLPESSLVK AMGNCA
 OMIM    U34070 Genomic DNA
 3D Structure    ModBase 3D Structure for P49715
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In. 20mM Tris-HCl pH7.5, 0.1M NaCl, 5mM beta-Mercaptoethanol.
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of CEBP-alpha recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CEBP-alpha recombinant protein

   CCAAT/enhancer binding protein (C/EBP) alpha is a family of transcription factors that all contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in dimerization and DNA binding. C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP family consist of several related proteins, C/EBP alpha, beta, gamma,delta, that form homodimers and that form heterodimers with each other. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein; a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. C/EBPs differ significantly in their physiological functions and in their downstream target genes. For example, mice lacking C/EBP alpha die shortly after birth due to severe hypoglycemia and the absence of glycogen storage in liver, whereas knockout of C/EBPbeta causes defects in female reproduction The bZip region of CEBP-alpha (residues 270-358)was produced in E Coli and purified by ion-exchange chromatography and FPLC gel-filtration chromatography.
 Product Categories/Family for CEBP-alpha recombinant protein    Cell Cycle
 Applications Tested/Suitable for CEBP-alpha recombinant protein   

SDS-PAGE

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 SDS-Page of CEBP-alpha recombinant protein    CEBP-alpha recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for CEBP-alpha. It may not necessarily be applicable to this product.
 NCBI GI #    28872794
 NCBI GeneID    1050
 NCBI Accession #    NP_004355 [Other Products]
 NCBI GenBank Nucleotide #    NM_004364.4 [Other Products]
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 UniProt Primary Accession #    P49715 [Other Products]
 UniProt Secondary Accession #    P78319; Q05CA4; A7LNP2 [Other Products]
 UniProt Related Accession #    P49715 [Other Products]
 Molecular Weight    14.5kDa (126aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    CCAAT/enhancer-binding protein alpha isoform a
 NCBI Official Synonym Full Names    CCAAT/enhancer binding protein alpha
 NCBI Official Symbol    CEBPA [Similar Products]
 NCBI Official Synonym Symbols   
CEBP; C/EBP-alpha
[Similar Products]
 NCBI Protein Information    CCAAT/enhancer-binding protein alpha
 UniProt Protein Name    CCAAT/enhancer-binding protein alpha
 UniProt Gene Name    CEBPA [Similar Products]
 UniProt Synonym Gene Names    C/EBP alpha [Similar Products]
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 NCBI Summary for CEBP-alpha    This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
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 UniProt Comments for CEBP-alpha    Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites ().
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Product References and Citations for CEBP-alpha recombinant protein

   Subramanian,L., et.al. (2003) J.Biol.Chem. 278 (11) 9134 - 9141; Gombart,A.F., et al (2002) Blood 99 (4) 1332-1340;
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 Research Articles on CEBP-alpha    1. This is the first study providing evidence that the c.690G>T, p.(Thr230Thr) (rs34529039) polymorphism of the CEBPA gene, together with up-regulation of its mRNA expression, are negative factors worsening ovarian cancer outcome
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CEBP-alpha recombinant proteinPathways associated with CEBP-alpha recombinant protein
 Reference Product  PubMed Publications
 JUN recombinant protein  >289 publications with CEBP-alpha and JUN
 RUNX1 recombinant protein  >130 publications with CEBP-alpha and RUNX1
 CEBPB recombinant protein  >78 publications with CEBP-alpha and CEBPB
 MYC recombinant protein  >64 publications with CEBP-alpha and MYC
 PPARG recombinant protein  >63 publications with CEBP-alpha and PPARG
 CEBPD recombinant protein  >41 publications with CEBP-alpha and CEBPD
 FOS recombinant protein  >27 publications with CEBP-alpha and FOS
 CDK2 recombinant protein  >19 publications with CEBP-alpha and CDK2
 EP300 recombinant protein  >9 publications with CEBP-alpha and EP300
 RB1 recombinant protein  >2 publications with CEBP-alpha and RB1
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Differentiation Of White And Brown Adipocyte Pathway antibodies  Differentiation Of White And Brown Adipocyte Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 IL-4 Signaling Pathway antibodies  IL-4 Signaling Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
Diseases associated with CEBP-alpha recombinant proteinOrgans/Tissues associated with CEBP-alpha recombinant protein
 Disease Name  Pubmed Publications
 Leukemia, Myeloid, Acute Antibodies  >637 publications with CEBP-alpha and Leukemia, Myeloid, Acute
 Obesity Antibodies  >459 publications with CEBP-alpha and Obesity
 Inflammation Antibodies  >136 publications with CEBP-alpha and Inflammation
 Liver Diseases Antibodies  >127 publications with CEBP-alpha and Liver Diseases
 Insulin Resistance Antibodies  >122 publications with CEBP-alpha and Insulin Resistance
 Necrosis Antibodies  >107 publications with CEBP-alpha and Necrosis
 Fatty Liver Antibodies  >97 publications with CEBP-alpha and Fatty Liver
 Weight Gain Antibodies  >91 publications with CEBP-alpha and Weight Gain
 Disease Models, Animal Antibodies  >82 publications with CEBP-alpha and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >56 publications with CEBP-alpha and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >604 publications with CEBP-alpha and Blood
 Adipose Tissue Antibodies  >498 publications with CEBP-alpha and Adipose Tissue
 Liver Antibodies  >450 publications with CEBP-alpha and Liver
 Connective Tissue Antibodies  >333 publications with CEBP-alpha and Connective Tissue
 Bone Antibodies  >323 publications with CEBP-alpha and Bone
 Bone Marrow Antibodies  >264 publications with CEBP-alpha and Bone Marrow
 Lung Antibodies  >94 publications with CEBP-alpha and Lung
 Brain Antibodies  >72 publications with CEBP-alpha and Brain
 Embryonic Tissue Antibodies  >64 publications with CEBP-alpha and Embryonic Tissue
 Kidney Antibodies  >52 publications with CEBP-alpha and Kidney
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