Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow CHMP2B  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Bile Acid-CoA:Amino Acid N-Acyltransferase (BAAT) ELISA Kit
 • B Cell Leukemia X long (bcl-xl ) ELISA Kit
 • TGM2 ELISA Kit
 • Sonic HedgeHog (SHH) Recombinant Protein
 • B-Type Natriuretic Peptide (BNP) ELISA Kit
 • Talin-2 (TLN2) Antibody
 • H5 (A-Hong Kong-483-97)(H5N1) Antibody
 • NR0B1 Antibody
 • GST3-GSTP1 Antibody
 • Alkaline Phosphatase (ALP) ELISA Kit
 • SLC31A2 Antibody
 • CD90 Antibody
 • Alpha soluble NSF attachment protein (NAPA) ELISA Kit
 • IL-3 ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

CHMP2B recombinant protein

Scan QR to view Datasheet Catalog #    MBS204316
SDS-Page
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHMP2B, Recombinant Protein

 Also Known As   

CHMP2B, 1-213aa, Human, His tag, E Coli

 Product Synonym Names    Chromatin modifying protein 2B; DMT1; VPS2B; VPS2-2; CHMP2.5; DKFZp564O123
 Product Gene Name   

CHMP2B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MGSSHHHHHH SSGLVPRGSH MASLFKKKTV DDVIKEQNRE LRGTQRAIIR DRAALEKQEK QLELEIKKMA KIGNKEACKV LAKQLVHLRK QKTRTFAVSS KVTSMSTQTK VMNSQMKMAG AMSTTAKTMQ AVNKKMDPQK TLQTMQNFQK ENMKMEMTEE MINDTLDDIF DGSDDEEESQ DIVNQVLDEI GIEISGKMAK APSAARSLPS ASTSKATISD EEIERQLKAL GVD
 OMIM    AF151842 mRNA
 3D Structure    ModBase 3D Structure for Q9UQN3
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl.
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
Section Bar
 Antigen Species    Human
 Tag Information    His-tag
Section Bar
 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of CHMP2B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for CHMP2B recombinant protein

   CHMP2B belongs to the vacuolar sorting protein family. It is a component of the ESCRT-III complex. This complex is crucial for sorting endosomal articles into multivesicular bodies (MVBs), and are also required for the formation of these bodies. CHMP2B widely expressed in brain, heart, skeletal muscle, small intestine, pancreas, lung, placenta and leukocytes. Recombinant human CHMP2B protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for CHMP2B recombinant protein    Neuroscience
 Applications Tested/Suitable for CHMP2B recombinant protein   

SDS-PAGE

Section Bar
 SDS-Page of CHMP2B recombinant protein    CHMP2B recombinant protein SDS-Page image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CHMP2B. It may not necessarily be applicable to this product.
 NCBI GI #    40254866
 NCBI GeneID    25978
 NCBI Accession #    NP_054762 [Other Products]
 NCBI GenBank Nucleotide #    NM_014043.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q9UQN3 [Other Products]
 UniProt Secondary Accession #    Q53HC7; Q9Y4U6; B4DJG8 [Other Products]
 UniProt Related Accession #    Q9UQN3 [Other Products]
 Molecular Weight    26.1 kDa (233aa), confirmed by MALDI-TOF (molecular weight on SDS-PAGE will appear higher)
Table BarTOPTable Bar
 NCBI Official Full Name    charged multivesicular body protein 2b isoform 1
 NCBI Official Synonym Full Names    charged multivesicular body protein 2B
 NCBI Official Symbol    CHMP2B [Similar Products]
 NCBI Official Synonym Symbols   
DMT1; ALS17; VPS2B; VPS2-2; CHMP2.5
[Similar Products]
 NCBI Protein Information    charged multivesicular body protein 2b
 UniProt Protein Name    Charged multivesicular body protein 2b
 UniProt Synonym Protein Names   
CHMP2.5; Chromatin-modifying protein 2b; CHMP2b; Vacuolar protein sorting-associated protein 2-2; Vps2-2; hVps2-2
 Protein Family    Charged multivesicular body protein
 UniProt Gene Name    CHMP2B [Similar Products]
 UniProt Synonym Gene Names    CHMP2b; Vps2-2; hVps2-2 [Similar Products]
Section Bar
 NCBI Summary for CHMP2B    This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for CHMP2B    Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
Table BarTOPTable Bar
 

Product References and Citations for CHMP2B recombinant protein

   Rizzu P., et al. (2006) Am J Med Genet B Neuropsychiatr Genet. 141B (8):944-6.; Stuchell-Brereton MD., et al. (2007) Nature. 449 (7163):740-4.
Section Bar
 Research Articles on CHMP2B    1. We directly link TDP-43 loss of function toxicity to two genes with rare amyotrophic lateral sclerosis and frontotemporal lobar degeneration-causing mutations, CHMP2B and ErbB4
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with CHMP2B recombinant proteinPathways associated with CHMP2B recombinant protein
 Reference Product  PubMed Publications
 CHMP4B recombinant protein  >6 publications with CHMP2B and CHMP4B
 CHMP3 recombinant protein  >5 publications with CHMP2B and CHMP3
 CHMP2A recombinant protein  >5 publications with CHMP2B and CHMP2A
 VPS4B recombinant protein  >4 publications with CHMP2B and VPS4B
 CHMP4A recombinant protein  >3 publications with CHMP2B and CHMP4A
 VPS4A recombinant protein  >2 publications with CHMP2B and VPS4A
 CHMP6 recombinant protein  >1 publications with CHMP2B and CHMP6
 CHMP5 recombinant protein  >1 publications with CHMP2B and CHMP5
 Products by Pathway  Pathway Diagram
 Budding And Maturation Of HIV Virion Pathway antibodies  Budding And Maturation Of HIV Virion Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ESCRT-III Complex Pathway antibodies  ESCRT-III Complex Pathway Diagram
 ESCRT-III Complex Pathway antibodies  ESCRT-III Complex Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endosomal Sorting Complex Required For Transport (ESCRT) Pathway antibodies  Endosomal Sorting Complex Required For Transport (ESCRT) Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
Diseases associated with CHMP2B recombinant proteinOrgans/Tissues associated with CHMP2B recombinant protein
 Disease Name  Pubmed Publications
 Frontotemporal Dementia Antibodies  >98 publications with CHMP2B and Frontotemporal Dementia
 Frontotemporal Lobar Degeneration Antibodies  >70 publications with CHMP2B and Frontotemporal Lobar Degeneration
 Amyotrophic Lateral Sclerosis Antibodies  >33 publications with CHMP2B and Amyotrophic Lateral Sclerosis
 Memory Disorders Antibodies  >7 publications with CHMP2B and Memory Disorders
 Cognition Disorders Antibodies  >5 publications with CHMP2B and Cognition Disorders
 Chromosome 3-Linked Frontotemporal Dementia Antibodies  >3 publications with CHMP2B and Chromosome 3-Linked Frontotemporal Dementia
 AMYOTROPHIC LATERAL SCLEROSIS 17 Antibodies  >3 publications with CHMP2B and AMYOTROPHIC LATERAL SCLEROSIS 17
 Ovarian Diseases Antibodies  >2 publications with CHMP2B and Ovarian Diseases
 Learning Disorders Antibodies  >1 publications with CHMP2B and Learning Disorders
 Inflammation Antibodies  >1 publications with CHMP2B and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >61 publications with CHMP2B and Brain
 Nerve Antibodies  >59 publications with CHMP2B and Nerve
 Muscle Antibodies  >5 publications with CHMP2B and Muscle
 Eye Antibodies  >3 publications with CHMP2B and Eye
 Blood Antibodies  >3 publications with CHMP2B and Blood
 Embryonic Tissue Antibodies  >2 publications with CHMP2B and Embryonic Tissue
 Vascular Antibodies  >2 publications with CHMP2B and Vascular
 Ganglia Antibodies  >2 publications with CHMP2B and Ganglia
 Heart Antibodies  >1 publications with CHMP2B and Heart
 Ovary Antibodies  >1 publications with CHMP2B and Ovary
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions