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CHMP2B recombinant protein

Scan QR to view Datasheet Catalog #    MBS204316
SDS-PAGE
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHMP2B, Recombinant Protein

 Also Known As   

CHMP2B, 1-213aa, Human, His tag, E Coli

 Product Synonym Names    Chromatin modifying protein 2B; DMT1; VPS2B; VPS2-2; CHMP2.5; DKFZp564O123
 Product Gene Name   

CHMP2B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MASLFKKKTV DDVIKEQNRE LRGTQRAIIR DRAALEKQEK QLELEIKKMA KIGNKEACKV LAKQLVHLRK QKTRTFAVSS KVTSMSTQTK VMNSQMKMAG AMSTTAKTMQ AVNKKMDPQK TLQTMQNFQK ENMKMEMTEE MINDTLDDIF DGSDDEEESQ DIVNQVLDEI GIEISGKMAK APSAARSLPS ASTSKATISD EEIERQLKAL GVD
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 Purity/Purification    > 90 % by SDS - PAGE
 Form/Format    Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl.
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of CHMP2B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CHMP2B recombinant protein

   CHMP2B belongs to the vacuolar sorting protein family. It is a component of the ESCRT-III complex. This complex is crucial for sorting endosomal articles into multivesicular bodies (MVBs), and are also required for the formation of these bodies. CHMP2B widely expressed in brain, heart, skeletal muscle, small intestine, pancreas, lung, placenta and leukocytes. Recombinant human CHMP2B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for CHMP2B recombinant protein    Neuroscience
 Applications Tested/Suitable for CHMP2B recombinant protein   

SDS-PAGE

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 SDS-PAGE of CHMP2B recombinant protein    CHMP2B recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for CHMP2B. It may not necessarily be applicable to this product.
 NCBI GI #    40254866
 NCBI GeneID    25978
 NCBI Accession #    NP_054762 [Other Products]
 NCBI GenBank Nucleotide #    NM_014043.3 [Other Products]
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 UniProt Secondary Accession #    Q53HC7; Q9Y4U6; B4DJG8 [Other Products]
 UniProt Related Accession #    Q9UQN3 [Other Products]
 Molecular Weight    26.1 kDa (233aa), confirmed by MALDI-TOF (molecular weight on SDS-PAGE will appear higher)
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 NCBI Official Full Name    charged multivesicular body protein 2b isoform 1
 NCBI Official Synonym Full Names    charged multivesicular body protein 2B
 NCBI Official Symbol    CHMP2B [Similar Products]
 NCBI Official Synonym Symbols   
DMT1; ALS17; VPS2B; VPS2-2; CHMP2.5
[Similar Products]
 NCBI Protein Information    charged multivesicular body protein 2b; VPS2 homolog B; chromatin modifying protein 2B; vacuolar protein-sorting-associated protein 2-2
 UniProt Protein Name    Charged multivesicular body protein 2b
 UniProt Synonym Protein Names   
CHMP2.5; Chromatin-modifying protein 2b; CHMP2b; Vacuolar protein sorting-associated protein 2-2; Vps2-2; hVps2-2
 Protein Family    Charged multivesicular body protein
 UniProt Gene Name    CHMP2B [Similar Products]
 UniProt Synonym Gene Names    CHMP2b; Vps2-2; hVps2-2 [Similar Products]
 UniProt Entry Name    CHM2B_HUMAN
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 NCBI Summary for CHMP2B    This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CHMP2B    CHMP2B: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Defects in CHMP2B are the cause of frontotemporal dementia, chromosome 3-linked (FTD3). FTD3 is characterized by an onset of dementia in the late 50's initially characterized by behavioral and personality changes including apathy, restlessness, disinhibition and hyperorality, progressing to stereotyped behaviors, non-fluent aphasia, mutism and dystonia, with a marked lack of insight. The brains of individuals with FTD3 have no distinctive neuropathological features. They show global cortical and central atrophy, but no beta-amyloid deposits. Defects in CHMP2B are the cause of amyotrophic lateral sclerosis type 17 (ALS17). An adult-onset progressive neurodegenerative disorder with predominantly lower motor neuron involvement, manifest as muscle weakness and wasting of the upper and lower limbs, bulbar signs, and respiratory insufficiency. Belongs to the SNF7 family.

Chromosomal Location of Human Ortholog: 3p11.2

Cellular Component: nucleoplasm; mitochondrion; lysosome; late endosome membrane; late endosome; cytoplasm; plasma membrane; intracellular; nucleus; cytosol; endosome

Molecular Function: protein domain specific binding; protein binding

Biological Process: protein transport; viral reproduction; endosome organization and biogenesis; cell separation during cytokinesis; vacuolar transport; viral infectious cycle; cognition; endosome transport; mitotic metaphase plate congression; nuclear organization and biogenesis

Disease: Frontotemporal Dementia, Chromosome 3-linked; Amyotrophic Lateral Sclerosis 17
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Product References and Citations for CHMP2B recombinant protein

   Rizzu P., et al. (2006) Am J Med Genet B Neuropsychiatr Genet. 141B(8):944-6.
Stuchell-Brereton MD., et al. (2007) Nature. 449(7163):740-4.
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 Research Articles on CHMP2B    1. Protein kinase CK2 alpha is involved in the phosphorylation of the ESCRT-III subunits CHMP3 and CHMP2B, as well as of VPS4B/SKD1, an ATPase that mediates ESCRT-III disassembly.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CHMP2B recombinant proteinPathways associated with CHMP2B recombinant protein
 Reference Product  PubMed Publications
 CHMP4B recombinant protein  >5 publications with CHMP2B and CHMP4B
 CHMP2A recombinant protein  >4 publications with CHMP2B and CHMP2A
 VPS4B recombinant protein  >3 publications with CHMP2B and VPS4B
 CHMP4A recombinant protein  >2 publications with CHMP2B and CHMP4A
 VPS4A recombinant protein  >1 publications with CHMP2B and VPS4A
 Products by Pathway  Pathway Diagram
 Budding And Maturation Of HIV Virion Pathway antibodies  Budding And Maturation Of HIV Virion Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ESCRT-III Complex Pathway antibodies  ESCRT-III Complex Pathway Diagram
 ESCRT-III Complex Pathway antibodies  ESCRT-III Complex Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endosomal Sorting Complex Required For Transport (ESCRT) Pathway antibodies  Endosomal Sorting Complex Required For Transport (ESCRT) Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 Late Phase Of HIV Life Cycle Pathway antibodies  Late Phase Of HIV Life Cycle Pathway Diagram
Diseases associated with CHMP2B recombinant proteinOrgans/Tissues associated with CHMP2B recombinant protein
 Disease Name  Pubmed Publications
 Frontotemporal Dementia Antibodies  >76 publications with CHMP2B and Frontotemporal Dementia
 Frontotemporal Lobar Degeneration Antibodies  >50 publications with CHMP2B and Frontotemporal Lobar Degeneration
 Amyotrophic Lateral Sclerosis Antibodies  >27 publications with CHMP2B and Amyotrophic Lateral Sclerosis
 Atrophy Antibodies  >15 publications with CHMP2B and Atrophy
 Congenital Abnormalities Antibodies  >3 publications with CHMP2B and Congenital Abnormalities
 Frontotemporal Dementia, Chromosome 3-Linked Antibodies  >3 publications with CHMP2B and Frontotemporal Dementia, Chromosome 3-Linked
 Neurobehavioral Manifestations Antibodies  >1 publications with CHMP2B and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >1 publications with CHMP2B and Learning Disorders
 Inflammation Antibodies  >1 publications with CHMP2B and Inflammation
 Hypertrophy Antibodies  >1 publications with CHMP2B and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >48 publications with CHMP2B and Nerve
 Brain Antibodies  >43 publications with CHMP2B and Brain
 Muscle Antibodies  >4 publications with CHMP2B and Muscle
 Eye Antibodies  >3 publications with CHMP2B and Eye
 Blood Antibodies  >3 publications with CHMP2B and Blood
 Embryonic Tissue Antibodies  >2 publications with CHMP2B and Embryonic Tissue
 Vascular Antibodies  >2 publications with CHMP2B and Vascular
 Heart Antibodies  >1 publications with CHMP2B and Heart
 Ovary Antibodies  >1 publications with CHMP2B and Ovary
 Liver Antibodies  >1 publications with CHMP2B and Liver
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